Tolerance to the neuron-specific paraneoplastic HuD antigen

PLoS ONE

Volumn 4, Issue 6, 2009, Pages

  DeLuca, Ilana ^a   Blachére, Nathalie E ^a   Santomasso, Bianca ^a   Darnell, Robert B ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GAMMA INTERFERON; HU ANTIGEN; HU PROTEIN; PERTUSSIS TOXIN;

ACTIVE IMMUNIZATION; ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ARTICLE; C57BL 6 MOUSE; CD8+ T LYMPHOCYTE; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; LUNG SMALL CELL CANCER; MOUSE; NONHUMAN; PARANEOPLASTIC SYNDROME; T LYMPHOCYTE ACTIVATION; ANIMAL; AUTOIMMUNITY; BONE MARROW CELL; BRAIN; C57BL MOUSE; CHEMISTRY; CYTOLOGY; KIDNEY; LUNG TUMOR; METABOLISM; NERVE CELL; SPLEEN;

MUS;

ADOPTIVE TRANSFER; ANIMALS; AUTOIMMUNITY; BONE MARROW CELLS; BRAIN; CD8-POSITIVE T-LYMPHOCYTES; EPITOPES; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; KIDNEY; LUNG NEOPLASMS; MICE; MICE, INBRED C57BL; NEURONS; SMALL CELL LUNG CARCINOMA; SPLEEN;

EID: 66849124888     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005739     Document Type: Article

References (38)

1. Medawar PB (1948) Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. Br J Exp Pathol 29: 58-69.
2. Galea I, Bechmann I, Perry VH (2007) What is immune privilege (not)? Trends Immunol 28: 12-18.
3. Carson MJ, Doose JM, Melchior B, Schmid CD, Ploix CC (2006) CNS immune privilege: hiding in plain sight. Immunol Rev 213: 48-65.
4. Hickey WF (2001) Basic principles of immunological surveillance of the normal central nervous system. Glia 36: 118-124.
5. Galea I, Bernardes-Silva M, Forse PA, van Rooijen N, Liblau RS, et al. (2007) An antigen-specific pathway for CD8 T cells across the blood-brain barrier. J Exp Med 204: 2023-2030.
6. Harling-Berg CJ, Knopf PM, Cserr HF (1991) Myelin basic protein infused into cerebrospinal fluid suppresses experimental autoimmune encephalomyelitis. J Neuroimmunol 35: 45-51.
7. Harling-Berg CJ, Park TJ, Knopf PM (1999) Role of the cervical lymphatics in the Th2-type hierarchy of CNS immune regulation. J Neuroimmunol 101: 111-127.
8. Graus F, Dalmou J, Rene R, Tora M, Malats N, et al. (1997) Anti-Hu antibodies in patients with small-cell lung cancer: association with complete response to therapy and improved survival. J Clin Oncol 15: 2866-2872.
9. Dalmau J, Graus F, Rosenblum MK, Posner JB (1992) Anti-Hu-associated paraneoplastic encephalomyelitis/sensory neuronopathy. A clinical study of 71 patients. Medicine (Baltimore) 71: 59-72.
10. Dalmau J, Furneaux HM, Gralla RJ, Kris MG, Posner JB (1990) Detection of the anti-Hu antibody in the serum of patients with small cell lung cancer - a quantitative western blot analysis. Ann Neurol 27: 544-552.
11. Manley GT, Smitt PS, Dalmau J, Posner JB (1995) Hu antigens: reactivity with Hu antibodies, tumor expression, and major immunogenic sites. Ann Neurol 38: 102-110.
12. Jaeckle K, Houghton AN, Nielsen SL, Posner JB (1983) Demonstration of serum anti-Purkinje antibody in paraneoplastic cerebellar degeneration and preliminary antigenic characterization. Ann Neurol 111.
13. Darnell RB (1996) Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity and the brain. Proc Natl Acad Sci USA 93: 4529-4536.
14. Darnell RB, Posner JB (2003) Paraneoplastic syndromes involving the nervous system. N Engl J Med 349: 1543-1554.
15. Benyahia B, Liblau R, Merle-Beral H, Tourani JM, Dalmau J, et al. (1999) Cell-mediated autoimmunity in paraneoplastic neurological syndromes with anti-Hu antibodies. Ann Neurol 45: 162-167.
16. Jean WC, Dalmau J, Ho A, Posner JB (1994) Analysis of the IgG subclass distribution and inflammatory infiltrates in patients with anti-Hu-associated paraneoplastic encephalomyelitis. Neurology 44: 140-147.
17. Santomasso BD, Roberts WK, Thomas A, Williams T, Blachere NE, et al. (2007) A T-cell receptor associated with naturally occurring human tumor immunity. Proceedings of the National Academy of Sciences of the United States of America 104: 19073-19078.
18. Albert ML, Darnell JC, Bender A, Francisco LM, Bhardwaj N, et al. (1998) Tumor-specific killer cells in paraneoplastic cerebellar degeneration. Nat Med 4: 1321-1324.
19. de Beukelaar JW, Verjans GM, van Norden Y, Milikan JC, Kraan J, et al. (2007) No evidence for circulating HuD-specific CD8+ T cells in patients with paraneoplastic neurological syndromes and Hu antibodies. Cancer Immunol Immunother 56: 1501-1506.
20. Plonquet A, Garcia-Pons F, Fernandez E, Philippe C, Marquet J, et al. (2003) Peptides derived from the onconeural HuD protein can elicit cytotoxic responses in HHD mouse and human. J Neuroimmunol 142: 93-100.
21. Rousseau A, Benyahia B, Dalmau J, Connan F, Guillet JG, et al. (2005) T cell response to Hu-D peptides in patients with anti-Hu syndrome. J Neurooncol 71: 231-236.
22. Tanaka M, Maruyama Y, Sugie M, Motizuki H, Kamakura K, et al. (2002) Cytotoxic T cell activity against peptides of Hu protein in anti-Hu syndrome. J Neurol Sci 201: 9-12.
23. Roberts WK, IJ D, A T, J F, T W, et al. (2009) Patients with lung cancer and the paraneoplastic Hu syndrome harbor HuD-specific Type 2 CD8+ T cells. J Clin Invest;in press.
24. Akamatsu W, Fujihara H, Mitsuhashi T, Yano M, Shibata S, et al. (2005) The RNA-binding protein HuD regulates neuronal cell identity and maturation. Proc Natl Acad Sci U S A 102: 4625-4630.
25. Inaba K, Inaba M, Romani H, Aya M, Deguchi S, et al. (1992) Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 176: 1693-1702.
26. Dyall R, Fremont DH, Jameson SC, Nikolic-Zugic J (1996) T cell receptor (TCR) recognition of MHC class I variants: intermolecular second-site reversion provides evidence for peptide/MHC conformational variation. J Exp Med 184: 253-258.
27. Darnell JC, Albert ML, Darnell RB (2000) cdr2, a target antigen of naturally occuring human tumor immunity, is widely expressed in gynecological tumors. Cancer Res 60: 2136-2139.
28. Neumann H, Schmidt H, Cavalie A, Jenne D, Wekerle H (1997) Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha. J Exp Med 185: 305-316.
29. Ransohoff RM, Kivisakk P, Kidd G (2003) Three or more routes for leukocyte migration into the central nervous system. Nat Rev Immunol 3: 569-581.
30. Okano HJ, Darnell RB (1997) A hierarchy of Hu RNA binding proteins in developing and adult neurons. J Neurosci 17: 3024-3037.
31. Derbinski J, Gabler J, Brors B, Tierling S, Jonnakuty S, et al. (2005) Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp Med 202: 33-45.
32. Lee JW, Epardaud M, Sun J, Becker JE, Cheng AC, et al. (2007) Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol 8: 181-190.
33. de Vos AF, van Meurs M, Brok HP, Boven LA, Hintzen RQ, et al. (2002) Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs. J Immunol 169: 5415-5423.
34. Karman J, Ling C, Sandor M, Fabry Z (2004) Initiation of immune responses in brain is promoted by local dendritic cells. J Immunol 173: 2353-2361.
35. Albert ML, Sauter B, Bhardwaj N (1998) Dendritic cells acquire antigen from apoptotic cells and induce class I- restricted CTLs. Nature 392: 86-89.
36. Banerjee R, Lund RD (1992) A role for microglia in the maintenance of photoreceptors in retinal transplants lacking pigment epithelium. J Neurocytol 21: 235-243.
37. Streilein JW, Ma N, Wenkel H, Ng TF, Zamiri P (2002) Immunobiology and privilege of neuronal retina and pigment epithelium transplants. Vision Res 42: 487-495.
38. Heath WR, Kurts C, Miller JF, Carbone FR (1998) Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens. J Exp Med 187: 1549-1553.