Grape juice concentrate modulates p16 expression in high fat diet-induced liver steatosis in Wistar rats

Toxicology Mechanisms and Methods

Volumn 22, Issue 3, 2012, Pages 218-224

  Ferreira, Andressa Orlandeli ^a   Boiago Gollücke, Andréa Pittelli ^b   Noguti, Juliana ^a   Da Silva, Victor Hugo Pereira ^a   Hojo Yamamura, Elsa Tiemi ^b   Ribeiro, Daniel Araki ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b CATHOLIC UNIVERSITY OF SANTOS   (Brazil)

Author keywords

Cholesterol diet; Grape juice; P16; P21; P53; Rats

Indexed keywords

PROTEIN P16; PROTEIN P21; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE REGULATION; CHOLESTEROL INTAKE; CONTROLLED STUDY; DIETARY INTAKE; FATTY LIVER; GRAPE JUICE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIPID DIET; LIVER INJURY; LIVER PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT;

ANIMALS; APOPTOSIS; BEVERAGES; CELL CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; FATTY LIVER; FRUIT; IMMUNOHISTOCHEMISTRY; LIVER; MALE; PLANT EXTRACTS; RATS; RATS, WISTAR; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53; VITIS;

RATTUS; RATTUS NORVEGICUS; VITACEAE;

EID: 84856885531     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2011.631196     Document Type: Article

References (34)

1. ADA American Dietetic Association. 2004. Position of the American Dietetic Association, Functional Foods. J Am Diet Assoc 104: 814-826.
2. Aguiar O Jr, Gollücke AP, de Moraes BB, Pasquini G, Catharino RR, Riccio MF, Ihara SS, Ribeiro DA. 2011. Grape juice concentrate prevents oxidative DNA damage in peripheral blood cells of rats subjected to a high-cholesterol diet. Br J Nutr 105:694-702.
3. Andrade ER, Cruz IB, Andrade VV, Piccoli JC, González-Gallego J, Barrio JP, González P. 2011. Evaluation of the potential protective efects of ad libitum black grape juice against liver oxidative damage in whole-body acute X-irradiated rats. Food Chem Toxicol 49:1026-1032.
4. Beecher GR. 2003. Overview of dietary favonoids: Nomenclature, occurrence and intake. J Nutr 133:3248S-3254S. (Pubitemid 37222252)
5. Beseler L. 1999. Efects on Behavior and cognition, diet and artifcial colors favors and preservatives. Int Ped 14:41-43.
6. Brunt EM, Walsh SN, Hayashi PH, Labundy J, Di Bisceglie AM. 2007. Hepatocyte senescence in end-stage chronic liver disease: A study of cyclin-dependent kinase inhibitor p21 in liver biopsies as a marker for progression to hepatocellular carcinoma. Liver Int 27:662-671. (Pubitemid 47097317)
7. Dani C, Oliboni LS, Umezu FM, Pasquali MA, Salvador M, Moreira JC, Henriques JA. 2009. Antioxidant and antigenotoxic activities of purple grape juice-organic and conventional-in adult rats. J Med Food 12:1111-1118.
8. Derdak Z, Lang CH, Villegas KA, Tong M, Mark NM, de la Monte SM, Wands JR. 2011. Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. J Hepatol 54:164-172.
9. Dimri GP, Nakanishi M, Desprez PY, Smith JR, Campisi J. 1996. Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein. Mol Cell Biol 16:2987-2997. (Pubitemid 26161305)
10. Elledge SJ, Harper JW. 1994. Cdk inhibitors: On the threshold of checkpoints and development. Curr Opin Cell Biol 6:847-852. (Pubitemid 24357916)
11. Farrell GC, Larter CZ. 2006. Nonalcoholic fatty liver disease: From steatosis to cirrhosis. Hepatology 43:S99-S112.
12. Feldstein AE, Canbay A, Guicciardi ME, Higuchi H, Bronk SF, Gores GJ. 2003. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. J Hepatol 39:978-983. (Pubitemid 37523769)
13. Fracalossi AC, Miranda SR, Oshima CT, Franco M, Ribeiro DA. 2010. The role of matrix metalloproteinases 2 and 9 during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. J Mol Histol 41:19-25.
14. Goldsworthy TL, Fransson-Steen R, Maronpot RR. 1996. Importance of and approaches to quantifcation of hepatocyte apoptosis. Toxicol Pathol 24:24-35. (Pubitemid 26066416)
15. Gollucke A P, Souza JC, Tavares DQ. 2008. (+)-Catechin and (-)-epicatechin levels of concentrated and ready-to-drink grape juices through storage. Int J Food Sci Tech 43:1855-1859.
16. Johnson AL. 2003. Intracellular mechanisms regulating cell survival in ovarian follicles. Anim Reprod Sci 78:185-201. (Pubitemid 37096412)
17. Johnstone RJ, Ruef AA, Lowe SW. 2002. Apoptosis: A link between cancer genetics and chemotherapy. Cell 108:153-164. (Pubitemid 34161136)
18. Manzoni MS, Rossi EA, Carlos IZ, Vendramini RC, Duarte AC, Dâmaso AR. 2005. Fermented soy product supplemented with isofavones afected fat depots in juvenile rats. Nutrition 21:1018-1024. (Pubitemid 41266993)
19. Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, McCullough AJ, Natale S, Forlani G, Melchionda N. 2001. Nonalcoholic fatty liver disease: A feature of the metabolic syndrome. Diabetes 50:1844-1850. (Pubitemid 33641605)
20. Marchesini G, Moscatiello S, Di Domizio S, Forlani G. 2008. Obesity-associated liver disease. J Clin Endocrinol Metab 93:S74-S80.
21. May P, May E. 1999. Twenty years of p53 research: Structural and functional aspects of the p53 protein. Oncogene 18:7621-7636. (Pubitemid 30052689)
22. Mertens-Talcott SU, Lee JH, Percival SS, Talcott ST. 2006. Induction of cell death in Caco-2 human colon carcinoma cells by ellagic acid rich fractions from muscadine grapes (Vitis rotundifolia). J Agric Food Chem 54:5336-5343. (Pubitemid 44195709)
23. Michalopoulos GK. 2007. Liver regeneration. J Cell Physiol 213: 286-300. (Pubitemid 47509705)
24. Nichols JA, Katiyar SK. 2010. Skin photoprotection by natural polyphenols: Anti-infammatory, antioxidant and DNA repair mechanisms. Arch Dermatol Res 302:71-83.
25. Park YK, Park E, Kim JS, Kang MH. 2003. Daily grape juice consumption reduces oxidative DNA damage and plasma free radical levels in healthy Koreans. Mutat Res 529:77-86. (Pubitemid 37013390)
26. Scalbert A, Johnson IT, Saltmarsh M. 2005. Polyphenols: Antioxidants and beyond. Am J Clin Nutr 81:215S-217S.
27. Sharma SD, Meeran SM, Katiyar SK. 2007. Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-kappaB signaling in in vivo SKH-1 hairless mice. Mol Cancer Ter 6:995-1005. (Pubitemid 46554569)
28. Taub R. 2004. Liver regeneration: From myth to mechanism. Nat Rev Mol Cell Biol 5:836-847. (Pubitemid 39336277)
29. Vogelstein B, Kinzler KW. 1993. The multistep nature of cancer. Trends Genet 9:138-141. (Pubitemid 23098782)
30. Wang H, Lafdil F, Kong X, Gao B. 2011a. Signal transducer and activator of transcription 3 in liver diseases: A novel therapeutic target. Int J Biol Sci 7:536-550.
31. Wang XY, Wang YG, Wang YF. 2011b. Ginsenoside Rb1, Rg1 and three extracts of traditional Chinese medicine attenuate ultraviolet B-induced G1 growth arrest in HaCaT cells and dermal fbroblasts involve down-regulating the expression of p16, p21 and p53. Photodermatol Photoimmunol Photomed 27:203-212.
32. Wätjen W, Michels G, Stefan B, Niering P, Chovolou Y, Kampkötter A, Tran-Ti QH, Proksch P, Kahl R. 2005. Low concentrations of favonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis. J Nutr 135:525-531. (Pubitemid 40365213)
33. Zhang X, Tachibana S, Wang H, Hisada M, Williams GM, Gao B, Sun Z. 2010. Interleukin-6 is an important mediator for mitochondrial DNA repair after alcoholic liver injury in mice. Hepatology 52: 2137-2147.
34. Zhang XG, Xu P, Liu Q, Yu CH, Zhang Y, Chen SH, Li YM. 2006. Efect of tea polyphenol on cytokine gene expression in rats with alcoholic liver disease. HBPD INT 5:268-272. (Pubitemid 43826921)