Soluble peptide treatment reverses CD8 T-cell-induced disease in a mouse model of spontaneous tissue-selective autoimmunity

Journal of Investigative Dermatology

Volumn 132, Issue 3 PART 1, 2012, Pages 677-686

  Paek, So Yeon ^a   Miyagawa, Fumi ^a   Zhang, Hong ^a   Linton, Jay T ^a   Hoover, Shelley B ^a   Simpson, R Mark ^a   Katz, Stephen I ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR; CYTOKERATIN 14; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; OVALBUMIN; PEPTIDE; SIINFEKL PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CD8+ T LYMPHOCYTE; CELL ACTIVATION; DOWN REGULATION; EXTERNAL EAR; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SKIN DISEASE; SPLEEN CELL; SPONTANEOUS TISSUE SELECTIVE AUTOIMMUNITY;

EID: 84856845028     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2011.347     Document Type: Article

References (24)

1. Aichele P, Brduscha-Riem K, Oehen S et al. (1997) Peptide antigen treatment of naive and virus-immune mice: Antigen-specific tolerance versus immunopathology. Immunity 6:519-29 (Pubitemid 27239343)
2. Bercovici N, Heurtier A, Vizler C et al. (2000) Systemic administration of agonist peptide blocks the progression of spontaneous CD8-mediated autoimmune diabetes in transgenic mice without bystander damage. J Immunol 165:202-10 (Pubitemid 30429508)
3. Brocke S, Gijbels K, Allegretta M et al. (1996) Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature 379:343-6
4. Caspi R (2008) Immunotherapy of autoimmunity and cancer: The penalty for success. Nat Immunol 8:970-6
5. Duarte A, Correia O, Azevedo R et al. (2010) Bullous fixed drug eruption to etoricoxib-further evidence of intraepidermal CD8+ T cell involvement. Eur J Dermatol 20:236-8
6. Dubois P, Pihlgren M, Tomkowiak M et al. (1998) Tolerant CD8 T cells induced by multiple injections of peptide antigen show impaired TCR signaling and altered proliferative responses in vitro and in vivo. J Immunol 161:5260-7 (Pubitemid 28519085)
7. Gilhar A, Pillar T, Winterstein G et al. (1989) The pathogenesis of lichen planus. Br J Dermatol 120:541-4 (Pubitemid 19101176)
8. Goldberg D, Sabolinski M, Bystryn J-C (1984) Regional variation in the expression of bullous pemphigoid antigen and location of lesions in bullous pemphigoid. J Invest Dermatol 82:326-8 (Pubitemid 14131455)
9. Gutermuth J, Nograles K, Miyagawa F et al. (2009) Self-peptides prolong survival in murine autoimmunity via reduced IL-2/IL-7-mediated STAT5 signaling, CD8 coreceptor, and Valpha2 down-regulation. J Immunol 183:3130-8
10. Ishigami T, White C, Pender M (1998) Soluble antigen therapy induces apoptosis of autoreactive T cells preferentially in the target organ rather than in the peripheral lymphoid organs. Eur J Immunol 28:1626-35 (Pubitemid 28221167)
11. Larche M, Wraith D (2005) Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nat Med 11(4 suppl):S69-76 (Pubitemid 40562306)
12. Liblau R, Tisch R, Bercovici N et al. (1997) Systemic antigen in the treatment of T-cell-mediated autoimmune diseases. Immunol Today 18:599-604 (Pubitemid 28010972)
13. Liblau R, Wong F, Mars L et al. (2002) Autoreactive CD8 T cells in organspecific autoimmunity: Emerging targets for therapeutic intervention. Immunity 17:1-6 (Pubitemid 34874613)
14. Lohr J, Knoechel B, Nagabhushanam V et al. (2005) T-cell tolerance and autoimmunity to systemic and tissue-restricted self-antigens. Immunol Rev 204:116-27 (Pubitemid 40460497)
15. McGargill M, Derbinski J, Hogquist K (2000) Receptor editing in developing T cells. Nat Immunol 1:336-41
16. McGargill M, Mayerova D, Stefanski H et al. (2002) A spontaneous CD8 T cell-dependent autoimmune disease to an antigen expressed under the human keratin 14 promoter. J Immunol 169:2141-7 (Pubitemid 34857681)
17. Miyagawa F, Gutermuth J, Zhang H et al. (2010) The use of mouse models to better understand mechanisms of autoimmunity and tolerance. J Autoimmun 35:192-8
18. Park J-H, Adoro S, Lucas P et al. (2007) 'Coreceptor tuning': Cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat Immunol 8:1049-59 (Pubitemid 47430446)
19. Roopashree M, Gondhalekar R, Shashikanth M et al. (2010) Pathogenesis of oral lichen planus-a review. J Oral Pathol Med 39:729-34
20. Shibaki A, Sato A, Vogel J et al. (2004) Induction of GVHD-like skin disease by passively transferred CD8+ T-cell receptor transgenic T cells into keratin 14-ovalbumin transgenic mice. J Invest Dermatol 123:109-15 (Pubitemid 38833471)
21. Shiohara T (2009) Fixed drug eruption: Pathogenesis and diagnostic tests. Curr Opin Allergy Clin Immunol 9:316-21
22. Verdaguer J, Schmidt A, Amrani A et al. (1997) Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice. J Exp Med, 1663-76 (Pubitemid 27506280)
23. Walter U, Santamaria P (2005) CD8+ T cells in autoimmunity. Curr Opin Immunol 17:624-31
24. Weishaupt A, Gold R, Gaupp S et al. (1997) Antigen therapy eliminates T cell inflammation by apoptosis: Effective treatment of experimental autoimmune neuritis with recombinant myelin protein P2. Proc Natl Acad Sci USA 94:1338-43 (Pubitemid 27087852)