Genomic-derived markers for early detection of calcineurin inhibitor immunosuppressant-mediated nephrotoxicity

Toxicological Sciences

Volumn 124, Issue 1, 2011, Pages 23-34

  Cui, Yuxia ^a   Huang, Qihong ^b   Auman, James Todd ^a   Knight, Brian ^b   Jin, Xidong ^b   Blanchard, Kerry T ^b   Chou, Jeff ^a   Jayadev, Supriya ^b   Paules, Richard S ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Biomarker; Cyclosporine; FK506 (tacrolimus); Gene expression; Nephrotoxicity; Rapamycin; Renin angiotensin system

Indexed keywords

BIOLOGICAL MARKER; CYCLOSPORIN A; OLIVE OIL; PROTEIN KINASE WNK1; RAPAMYCIN; SODIUM CHLORIDE COTRANSPORTER; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DOWN REGULATION; DRUG DOSE COMPARISON; EARLY DIAGNOSIS; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY GRAFT REJECTION; KIDNEY TUBULE ABSORPTION; MALE; NEPHROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SODIUM TRANSPORT; TISSUE SPECIFICITY; TREATMENT DURATION; UREA NITROGEN BLOOD LEVEL; XENOGRAFT;

ANIMALS; CALCINEURIN; CHRONIC DISEASE; DOWN-REGULATION; EARLY DIAGNOSIS; GENETIC MARKERS; GRAFT REJECTION; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; MALE; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DRUG; RENIN-ANGIOTENSIN SYSTEM; SYMPORTERS;

EID: 84155175879     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr217     Document Type: Article

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