Interaction between hedgehog signalling and PAX6 dosage mediates maintenance and regeneration of the corneal epithelium

Molecular Vision

Volumn 18, Issue , 2012, Pages 139-150

  Kucerova, Romana ^a   Dorà, Natalie ^a   Mort, Richard L ^a   Wallace, Karen ^a   Leiper, Lucy J ^a   Lowes, Christina ^a   Neves, Carlos ^a   Walczysko, Petr ^a   Bruce, Freyja ^a   Fowler, Paul A ^a   Rajnicek, Ann M ^a   McCaig, Colin D ^a   Zhao, Min ^a   West, John D ^a   Martin Collinson, J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI3; TRANSCRIPTION FACTOR PAX6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CLONAL VARIATION; CONTROLLED STUDY; CORNEA EPITHELIUM; DESERT HEDGEHOG GENE; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; GENE; GENE DOSAGE; GENE EXPRESSION REGULATION; GENETIC CODE; GLI3 GENE; HETEROZYGOTE; HOMEOSTASIS; IN VIVO STUDY; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; NULL ALLELE; PAIRED BOX GENE 6 GENE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGENERATIVE ABILITY; SONIC HEDGEHOG GENE; UPREGULATION; WOUND HEALING;

ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; CLONE CELLS; EPITHELIAL CELLS; EPITHELIUM, CORNEAL; EYE PROTEINS; GENE DOSAGE; GENE EXPRESSION REGULATION; HEDGEHOG PROTEINS; HETEROZYGOTE; HOMEODOMAIN PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; NERVE TISSUE PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; PEPTIDES; PHOSPHATIDYLINOSITOL 3-KINASES; REGENERATION; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; VERATRUM ALKALOIDS; WOUND HEALING;

EID: 84856799154     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Shaw TJ, Martin P. Wound repair at a glance. J Cell Sci 2009; 122:3209-13. [PMID: 19726630]
2. Thoft RA, Friend J. The X, Y, Z hypothesis of corneal epithelial maintenance. Invest Ophthalmol Vis Sci 1983; 24:1442-3.[PMID: 6618809]
3. Cotsarelis G, Cheng SZ, Dong G, Sun T-T, Lavker RM. Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell 1989; 57:201-9.[PMID: 2702690]
4. Nagasaki T, Zhao J. Centripetal migration of corneal epithelial cells in the normal adult mouse. Invest Ophthalmol Vis Sci 2003; 44:558-66. [PMID: 12556383]
5. Sun T-T, Tseng SC, Lavker RM. Location of corneal epithelial stem cells. Nature 2010; 463:E10-1. [PMID: 20182462]
6. Davis J, Duncan MK, Robison WG Jr, Piatigorsky J. Requirement for Pax6 in corneal morphogenesis: a role in adhesion. J Cell Sci 2003; 116:2157-67. [PMID: 12692153]
7. Ramaesh K, Ramaesh T, Dutton GN, Dhillon B. Evolving concepts on the pathogenic mechanisms of aniridia related keratopathy. Int J Biochem Cell Biol 2005; 37:547-57. [PMID: 15618012]
8. +/- mouse. Invest Ophthalmol Vis Sci 2004; 45:1101-8. [PMID: 15037575]
9. +/- aniridia-related keratopathy. J Pathol 2008; 215:421-30. [PMID: 18491289]
10. +/- corneal epithelia. Invest Ophthalmol Vis Sci 2010; 51:1415-23. [PMID: 19933176]
11. Zaki PA, Collinson JM, Toraiwa J, Simpson TI, Price DJ, Quinn JC. Penetrance of eye defects in mice heterozygous for mutation of Gli3 is enhanced by heterozygous mutation of Pax6. BMC Dev Biol 2006; 6:46. [PMID: 17029624]
12. Echelard Y, Epstein DJ, St-Jacques B, Shen L, Mohler J, McMahon JA, McMahon AP. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 1993; 75:1417-30. [PMID: 7916661]
13. Ding Q, Fukami S, Meng X, Nishizaki Y, Zhang X, Sasaki H, Dlugosz A, Nakafuku M, Hui C. Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1. Curr Biol 1999; 9:1119-22. [PMID: 10531011]
14. Svärd J, Heby-Henricson K, Persson-Lek M, Rozell B, Lauth M, Bergstrom A, Ericson J, Toftgard R, Teglund S. Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell 2006; 10:187-97. [PMID: 16459298]
15. Osawa H, Ohnishi H, Takano K, Noguti T, Mashima H, Hoshino H, Kita H, Sato K, Matsui H, Sugano K. Sonic hedgehog stimulates the proliferation of rat gastric mucosal cells through ERK activation by elevating intracellular calcium concentration. Biochem Biophys Res Commun 2006; 344:680-7. [PMID: 16630542]
16. Riobó NA, Lu K, Ai X, Haines GM, Emerson CP Jr. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc Natl Acad Sci USA 2006; 103:4505-10. [PMID: 16537363]
17. Saika S, Muragaki Y, Okada Y, Miyamoto T, Ohnishi Y, Ooshima A, Kao WWY. Sonic hedgehog expression and role in healing corneal epithelium. Invest Ophthalmol Vis Sci 2004; 45:2577-85. [PMID: 15277480]
18. Fujita K, Miyamoto T, Saika S. Sonic hedgehog: its expression in a healing cornea and its role in neovascularisation. Mol Vis 2009; 15:1036-44. [PMID: 19471603]
19. Tan SS, Williams EA, Tam PPL. X-chromosome inactivation occurs at different times in different tissues of the postimplantation mouse embryo. Nat Genet 1993; 3:170-4. [PMID: 8499950]
20. Sasaki T, Irie-Sasaki J, Jones RG, Oliveira-dos-Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, Joza N, Mak TW, Ohashi PS, Suzuki A, Penninger JM. Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration. Science 2000; 287:1040-6. [PMID: 10669416]
21. Zhao M, Song B, Pu J, Wada T, Reid B, Guangping T, Wang F, Guo A, Walczysko P, Gu Y, Sasaki T, Suzuki A, Forrester JV, Bourne HR, Devreotes PN, McCaig CD, Penninger JM. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN. Nature 2006; 442:457-60. [PMID: 16871217]
22. Hazlett L, Masinick S, Mezger B, Barrett R, Kurpakus M, Garrett M. Ultrastructural, immunohistological and biochemical characterization of cultured mouse corneal epithelial cells. Ophthalmic Res 1996; 28:50-6. [PMID: 8726677]
23. Collinson JM, Morris L, Reid AI, Ramaesh T, Keighren MA, Flockhart JH, Hill RE, Tan S-S, Ramaesh K, Dhillon B, West JD. Clonal analysis of patterns of growth, stem cell activity and cell movement during the development and maintenance of the murine corneal epithelium. Dev Dyn 2002; 224:432-40.[PMID: 12203735]
24. Chen JK, Taipale J, Cooper MK, Beachy PA. Inhibition of Hedgehog signalling by direct binding of cyclopamine to Smoothened. Genes Dev 2002; 16:2743-8. [PMID: 12414725]
25. Kanda S, Mochizuki Y, Suematsu T, Miyata Y, Nomata K, Kanetake H. Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase. J Biol Chem 2003; 278:8244-9.[PMID: 12514186]
26. Elia D, Madhala D, Ardon E, Reshef R, Halevy O. Sonic hedgehog promotes proliferation and differentiation of adult muscle cells: Involvement of MAPK/ERK and PI3K/Akt pathways. Biochim Biophys Acta. 2007 [PMID: 17688959]
27. Takabatake T, Ogawa M, Takahashi TC, Mizuno M, Okamoto M, Takeshima K. Hedgehog and patched gene expression in adult ocular tissues. FEBS Lett 1997; 410:485-9.[PMID: 9237688]
28. Mort RL, Ramaesh T, Kleinjan DA, Morley SD, West JD. Mosaic analysis of stem cell function and wound healing in the mouse corneal epithelium. BMC Dev Biol 2009; 9:4. [PMID: 19128502]
29. Matise MP, Joyner AL. Gli genes in development and cancer. Oncogene 1999; 18:7852-9. [PMID: 10630638]
30. Mill P, Mo R, Hu MC, Dagnino L, Rosenblum ND, Hui C.-C. Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev Cell 2005; 9:293-303. [PMID: 16054035]
31. +/- mouse model of epithelial wound-healing delay. BMC Biol 2006; 4:27. [PMID: 16914058]
32. Zhang W, Zhao J, Chen L, Urbanowicz MM, Nagasaki T. Abnormal epithelial homeostasis in the cornea of mice with a destrin deletion. Mol Vis 2008; 14:1929-39. [PMID: 18958303]
33. Mort RL, Bentley AJ, Martin FL, Collinson JM, Douvaras P, Hill RE, Morley SD, Fullwood NJ, West JD. Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis. PLoS ONE 2011; 6:e28895. [PMID: 22220198]