TSH-induced gene expression involves regulation of self-renewal and differentiation-related genes in human bone marrow-derived mesenchymal stem cells

Journal of Endocrinology

Volumn 212, Issue 2, 2012, Pages 169-178

  Bagriacik, Emin Umit ^a   Yaman, Melek ^a   Haznedar, Rauf ^a   Sucak, Gulsan ^a   Delibasi, Tuncay ^b  

^a GAZI UNIVERSITY   (Turkey)

^b Diskapi Education and Research Hospital   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; THYROTROPIN; THYROTROPIN RECEPTOR;

ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CELL RENEWAL; GENE EXPRESSION; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; MESENCHYME CELL; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UNINDEXED SEQUENCE;

ANTIGENS, DIFFERENTIATION; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL MEMBRANE; CELLS, CULTURED; CHONDROCYTES; CHONDROGENESIS; CYCLIC AMP; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MESENCHYMAL STEM CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOBLASTS; PLURIPOTENT STEM CELLS; RECEPTORS, THYROTROPIN; RECOMBINANT PROTEINS; RNA, MESSENGER; SECOND MESSENGER SYSTEMS; THYROTROPIN ALFA;

EID: 84856797297     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-11-0404     Document Type: Article

References (37)

1. Abdallah BM & Kassem M 2008 Human mesenchymal stem cells: from basic biology to clinical applications. Gene Therapy 15 109-116.
2. Agretti P, Chiovato L, De Marco G, Marcocci C, Mazzi B, Sellari-Franceschini S, Vitti P, Pinchera A & Tonacchera M 2002 Real-time PCR provides evidence for thyrotropin receptor mRNA expression in orbital as well as in extraorbital tissues. European Journal of Endocrinology 147 733-739.
3. Agretti P, De Marco G, De Servi M, Marcocci C, Vitti P, Pinchera A & Tonacchera M 2005 Evidence for protein and mRNA TSHr expression in fibroblasts from patients with thyroid-associated ophthalmopathy (TAO) after adipocytic differentiation. European Journal of Endocrinology 152 777-784.
4. Bagriacik EU & Klein JR 2000 The thyrotropin (thyroid-stimulating hormone) receptor is expressed on murine dendritic cells and on a subset of CD45RB high lymph node T cells: functional role for thyroid-stimulating hormone during immune activation. Journal of Immunology 164 6158-6165.
5. Bell DM, Leung KK, Wheatley SC, Ng LJ, Zhou S, Ling KW, Sham MH, Koopman P, Tam PP & Cheah KS 1997 Sox9 directly regulates the type-II collagen gene. Nature Genetics 16 174-178.
6. Bell A, Gagnon A, Grunder L, Parikh SJ, Smith TJ & Sorisky A 2000 Functional TSH receptor in human abdominal preadipocytes and orbital fibroblasts. American Journal of Physiology. Cell Physiology 279 C335-C340.
7. Cowman MK, Slahetka MF, Hittner DM, Kim J, Forino M & Gadelrab G 1984 Polyacrylamide-gel electrophoresis and Alcian Blue staining of sulphated glycosaminoglycan oligosaccharides. Biochemical Journal 221 707-716.
8. Davies T, Marians R & Latif R 2002 The TSH receptor reveals itself. Journal of Clinical Investigation 110 161-164.
9. Dutton CM, Joba W, Spitzweg C, Heufelder AE & Bahn RS 1997 Thyrotropin receptor expression in adrenal, kidney, and thymus. Thyroid 7 879-884.
10. Ellerhorst JA, Sendi-Naderi A, Johnson MK, Cooke CP, Dang SM & Diwan AH 2006 Human melanoma cells express functional receptors for thyroid-stimulating hormone. Endocrine-Related Cancer 13 1269-1277.
11. Eyre DR, Pietka T, Weis MA & Wu JJ 2004 Covalent cross-linking of the NC1 domain of collagen type IX to collagen type II in cartilage. Journal of Biological Chemistry 279 2568-2573.
12. François S, Bensidhoum M, Mouiseddine M, Mazurier C, Allenet B, Semont A, Frick J, Saché A, Bouchet S, Thierry D et al. 2006 Local irradiation not only induces homing of human mesenchymal stem cells at exposed sites but promotes their widespread engraftment to multiple organs: a study of their quantitative distribution after irradiation damage. Stem Cells 24 1020-1029.
13. Gao F, Kwon SW, Zhao Y & Jin Y 2009 PARP1 poly (ADP-ribosylates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation. Journal of Biological Chemistry 284 22263-22273.
14. Go MJ, Takenaka C & Ohgushi H 2008 Forced expression of Sox2 or Nanog in human bone marrow derived mesenchymal stem cells maintains their expansion and differentiation capabilities. Experimental Cell Research 314 1147-1154.
15. Haraguchi K, Shimura H, Lin L, Saito T, Endo T & Onaya T 1996 Functional expression of thyrotropin receptor in differentiated 3T3-L1 cells: a possible model cell line of extrathyroidal expression of thyrotropin receptor. Biochemical and Biophysical Research Communications 223 193-198.
16. Hoermann R 1996 Stimulation of thyroidal and extrathyroidal thyrotropin receptors. Experimental and Clinical Endocrinology and Diabetes 104 (Suppl 4) 88-91.
17. Ivanova N, Dobrin R, Lu R, Kotenko I, Levorse J, DeCoste C, Schafer X, Lun Y & Lemischka IR 2006 Dissecting self-renewal in stem cells with RNA interference. Nature 442 533-538.
18. Johnson LR, Lamb KA, Gao Q, Nowling TK & Rizzino A 1998 Role of the transcription factor Sox-2 in the expression of the FGF-4 gene in embryonal carcinoma cells. Molecular Reproduction and Development 50 377-386.
19. Kamachi Y, Uchikawa M & Kondoh H 2000 Pairing sox off: with partners in the regulation of embryonic development. Trends in Genetics 16 182-187.
20. Katoh M & Katoh M 2007 WNT signaling pathway and stem cell signaling network. Clinical Cancer Research 13 4042-4045.
21. Kemp KC, Hows J & Donaldson C 2005 Bone marrow-derived mesenchymal stem cells. Leukemia and Lymphoma 46 1531-1544.
22. Kim WB, Lewis CJ, McCall KD, Malgor R, Kohn AD, Moon RT & Kohn LD 2007 Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms. Endocrinology 193 93-106.
23. Kolf CM, Cho E & Tuan RS 2007 Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthritis Research and Therapy 9 1-10.
24. Kursawe R & Paschke R 2000 Modulation of TSHR signaling by posttranslational modifications. Trends in Endocrinology and Metabolism 18 199-206.
25. Miura M, Tanaka K, Komatsu Y, Suda M, Yasoda A, Sakuma Y, Ozasa A & Nakao K 2002 Thyroid hormones promote chondrocyte differentiation in mouse ATDC5 cells and stimulate endochondral ossification in fetal mouse tibias through iodothyronine deiodinases in the growth plate. Journal of Bone and Mineral Research 17 443-454.
26. Niwa H, Miyazaki J & Smith AG 2000 Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nature Genetics 24 372-376.
27. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S & Marshak DR 1999 Multilineage potential of adult human mesenchymal stem cells. Science 284 143-147.
28. Quintarelli G, Scott JE & Dellovo MC 1964 The chemical and histochemical properties of Alcian Blue. II. Dye binding of tissue polyanions. Histochemie 4 86-98.
29. Scott JE, Quintarelli G & Dellovo MC 1964 The chemical and histochemical properties of alcian blue I. the mechanism of alcian blue staining. Histochemie 4 73-85.
30. Sellitti DF, Akamizu T, Doi SQ, Kim GH, Kariyil JT, Kopchik JJ & Koshiyama H 2000 Renal expression of two 'thyroid-specific' genes: thyrotropin receptor and thyroglobulin. Experimental Nephrology 8 235-243.
31. Stokes DG, Liu G, Dharmavaram R, Hawkins D, Piera-Velazquez S & Jimenez SA 2001 Regulation of type-II collagen gene expression during human chondrocyte de-differentiation and recovery of chondrocytespecific phenotype in culture involves Sry-type high-mobility-group box (SOX) transcription factors. Biochemical Journal 360 461-470.
32. Szkudlinski MW, Fremont V, Ronin C & Weintraub BD 2002 Thyroidstimulating hormone and thyroid-stimulating hormone receptor structure- function relationship. Physiological Reviews 82 473-502.
33. Toccafondi R, Rotella CM, Tanini A, Aterini S, Borrelli D, Loddi L & Arcangeli P 1982 Effects of TSH on cAMP levels and thyroid hormone release in human thyroid 'autonomous' nodules: relationship with iodothyronine and iodine content in thyroglobulin. Clinical Endocrinology 17 537-546.
34. Tsai JA, Janson A, Bucht E, Kindmark H, Marcus C, Stark A, Zemack HR & Torring O 2004 Weak evidence of thyrotropin receptors in primary cultures of human osteoblast-like cells. Calcified Tissue International 74 486-491.
35. Whetsell M, Bagriacik EU, Seetharamaiah GS, Prabhakar BS & Klein JR 1999 Neuroendocrine-induced synthesis of bone marrow-derived cytokines with inflammatory immunomodulating properties. Cell Immunology 192 159-166.
36. Wu JJ, Woods PE & Eyre DR 1992 Identification of cross-linking sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type IX bonding. Journal of Biological Chemistry 267 23007-23014.
37. Zhang P, Jimenez SA & Stokes DG 2003 Regulation of human Col9A1 gene expression: activation of the proximal promoter region by Sox9. Journal of Biological Chemistry 278 117-123.