Role of the transcription factor Sox-2 in the expression of the FGF-4 gene in embryonal carcinoma cells

Molecular Reproduction and Development

Volumn 50, Issue 4, 1998, Pages 377-386

  Johnson, Lance R ^a,b   Lamb, Kimberly A ^a,b   Gao, Qingsheng ^a,c   Nowling, Tamara K ^a   Rizzino, Angie ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c NEW ENGLAND BIOLABS   (United States)

Author keywords

Cis regulatory element; Fibroblast growth factor; Gel mobility shift analysis; Transient expression assay

Indexed keywords

FIBROBLAST GROWTH FACTOR 4; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CANCER GROWTH; EMBRYONAL CARCINOMA; ENHANCER REGION; GENE EXPRESSION REGULATION; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE;

ANIMALS; CARCINOMA, EMBRYONAL; DNA-BINDING PROTEINS; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; HMGB PROTEINS; MICE; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; RECOMBINANT FUSION PROTEINS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0031750323     PISSN: 1040452X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2795(199808)50:4<377::AID-MRD1>3.0.CO;2-F     Document Type: Article

References (42)

1. Bryans M, Lucas J, Knobloch T, Wilkie N, Lang J (1995): Regulation of FGF-4 enhancer activity by transcription factor NF-Y. Biochem Biophys Res Com 211:519-527.
2. Collignon J, Sockanathan S, Hacker A, Cohen-Tannoudji M, Norris D, Rastan S, Stevanovic M, Goodfellow PN, Lovell-Badge R (1996): A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development 122:509-520.
3. Curatola AM, Basilico C (1990): Expression of the K-fgf protooncogene is controlled by 3' regulatory elements which are specific for embryonal carcinoma cells. Mol Cell Biol 10:2475-2484.
4. Dailey L, Yuan H, Basilico C (1994): Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer. Mol Cell Biol 14:7758-7769.
5. Dignam JD, Lebovitz RM, Roeder RG (1983): Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucl Acids Res 11:1475-1489.
6. Feldman B, Poueymirou W, Papaiannou VE, DeChiara TM, Goldfarb M (1995): Requirement of FGF-4 for postimplantation mouse development. Science 267:246-249.
7. Fried M, Crothers DM (1981): Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. Nucl Acids Res 9:6505-6525.
8. Fuller-Pace F, Peters G, Dickson G (1991): Cell transformation by kFGF requires secretion but not glycosylation. J Cell Biol 115: 547-555.
9. Kasan S, Koda T, Kakinuma M (1994): An upstream NF-Y-binding site is required for transcriptional activation from the hst promoter in F9 embryonal carcinoma cells. J Biol Chem 269:25042-25048.
10. Heath JK, Isacke CM (1984): PC13 embryonal carcinoma-derived growth factor. EMBO J 3:2957-2962.
11. Jackson SM, Ericson J, Osporn TF, Edwards PA (1995): NF-Y has a novel role in sterol-dependent transcription of two cholesterogenic genes. J Biol Chem 270:21445-21448.
12. Jones-Villeneuve EMV, Rudnicki MA, Harris JF, McBurney M (1982): Retinoic acid induced neural differentiation of embryonal carcinoma cells. Mol Cell Biol 3:2271-2279.
13. Kamachi Y, Sockanathan S, Liu Q, Breitman B, Lovell-Badge R, Kondoh H (1995): Involvement of SOX proteins in lens-specific activation of crystalline genes. EMBO J 14:3510-3519.
14. Kelly D, Scholtz B, Orten D, Hinrichs S, Rizzino A (1995): Regulation of the transforming growth factor-β2 gene promoter in embryonal carcinoma cells and their differentiated cells: Differential utilization of transcription factors. Mol Reprod Dev 40:135-145.
15. Lamb K, Rosfjord E, Brigman K, Rizzino A (1996): Binding of transcription factors to widely-separated cis-regulatory elements of the murine FGF-4 gene. Mol Reprod Dev 44:460-471.
16. Lamb KA, Johnson LR, Rizzino A (1997): NF-Y binds to the CCAAT box motif of the FGF-4 gene and promotes FGF-4 expression in embryonal carcinoma cells. Mol Reprod Dev 48:301-309.
17. Lickteig K, Lamb K, Brigman K, Rizzino A (1996): Effects of oxidation and reduction on the binding of transcription factors to cis-regulatory elements in the FGF-4 gene. Mol Reprod Dev 44:146-152.
18. Ma Y-G, Rosfjord E, Huebert C, Wilder P, Tiesman J, Kelly D, Rizzino A (1992): Transcriptional regulation of the murine k-FGF gene in embryonic cell lines. Dev Biol 154:45-54.
19. McWhirter JR, Goulding M, Weiner JA, Chun J, Murre C (1997): A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development 124:3221-3232.
20. Miller K, Rizzino A (1994): Developmental regulation and signal transduction pathways of fibroblast growth factors and their receptors. In M Nilsen-Hamiliton, (ed): "Growth Factors and Signal Transduction in Development." New York: Wiley-Liss, pp 19-49.
21. Niswander L, Martin G (1992): FGF-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. Development 114:755-768.
22. Okamoto K, Okazawa H, Okuda A, Sakai M, Muramatsu M, Hamada H (1990): A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 60:461-472.
23. Payen E, Pailhoux E, Gianquinto L, Hayes H, Le Pennec N, Bezard J, Cotinot C (1997): The ovine SOX2 gene: Sequence, chromosomal localization and gonadal expression. Gene 189:143-147.
24. Peters G, Brookes S, Smith R, Placzek M, Dickson C (1989): The mouse homolog of the hst/k-FGF gene is adjacent to int-2 and is activated by proviral insertion in some virally induced mammary tumors. Proc Natl Acad Sci USA 86:5678-5682.
25. Rappolee DA, Sturm K, Schultz G, Pedersen R, Werb Z (1990): Expression of growth factor ligands and receptors in preimplantation mouse embryos. In S Heyner, E Wiley (eds): "Early Embryo Development and Paracrine Relationships." New York: Wiley-Liss, pp 11-25.
26. Rizzino A, Orme LS, De Larco JE (1983): Embryonal carcinoma cell growth and differentiation: Production of and response to molecules with transforming growth factor activity. Exp Cell Res 143:143-152.
27. Rizzino, A, Kuszynski C, Ruff E, Tiesman J (1988): Production and utilization of growth factors related to fibroblast growth factor by embryonal carcinoma cells and their differentiated cells. Dev Biol 129:61-71.
28. Rizzino A, Rosfjord E (1994): Transcriptional regulation of the murine k-fgf gene. Mol Reprod Dev 39:106-111.
29. Rosfjord E, Rizzino A (1994): The octamer binding motif present in the REX-1 promoter binds Oct-1 and Oct-3 expressed by EC cells and ES cells. Biochem Biophys Res Comm 203:1795-1802.
30. Rossant J, McBurney MW (1982): The developmental potential of a euploid male teratocarcinoma cell line after blastocyst injection. J Embryol Exp Morph 70:99-112.
31. Schöler HR, Hatzopoulos AK, Balling R, Suzuki N, Gruss P (1989): A family of octamer-specific proteins present during mouse embryogenesis: Evidence for germline-specific expression of an Oct factor. EMBO J 8:2543-2550.
32. Scholtz B, Lamb K, Rosfjord E, Kingsley M, Rizzino A (1996a): Appearance of nuclear protease activity after embryonal carcinoma cells undergo differentiation. Dev Biol 173:420-427.
33. Scholtz B, Kingsley-Kallesen M, Rizzino A (1996b): Transcription of the transforming growth factor-β2 gene is dependent on an E-box located between an essential cAMP response element/activating transcription factor motif and the TATA box of the gene. J Biol Chem 271:32375-32380.
34. Schoorlemmer J, Kruijer W (1991): Octamer-dependent regulation of the kFGF gene in embryonal carcinoma and embryonic stem cells. Mech Dev 36:75-86.
35. Seed B, Sheen JY (1988): A simple phase-extraction assay for chloramphenicol acetyltransferase activity. Gene 67:271-277.
36. Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SHC, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (1996): Fibroblast growth factor (FGF) homologous factors: New members of the FGF family implicated in nervous system development. Proc Natl Acad Sci USA 93:9850-9857.
37. Tiesman J, Rizzino A (1989): Expression and developmental regulation of the k-FGF oncogene in human and murine embryonal carcinoma cells. In Vitro Cell Dev Biol 25:1193-1198.
38. Velcich A, Delli-Bovi P, Mansukhani A, Ziff EB, Basilico C (1989): Expression of the K-fgf protooncogene is repressed during differentiation of F9 cells. Oncogene Res 5:31-37.
39. Wilder PJ, Kelly D, Brigman K, Peterson CL, Nowling T, Gao Q, McComb R, Capecchi MR, Rizzino A (1997): Inactivation of the FGF-4 gene in embryonic stem cells alters the growth and/or the survival of their differentiated progeny. Dev Biol 192:614-629.
40. Yoshida T, Muramatsu H, Muramatsu T, Sakamoto H, Katoh O, Sugimura T, Terada M (1988): Differential expression of two homologous and clustered oncogenes, Hst1 and Int-2, during differentiation of F9 cells. Biochem Biophys Res Comm 157:618-625.
41. Yamasaki M, Miyake A, Tagashira S, Itoh N (1996): Structure and function of the rat mRNA encoding a novel member of the fibroblast growth factor family. J Biol Chem 271:15918-15921.
42. Yuan H, Corbi N, Basilico C, Dailey L (1995): Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev 9:2635-2645.