Reference intervals for testosterone, androstenedione and SHBG levels in healthy females and males from birth until old age

Clinical Laboratory

Volumn 51, Issue 11-12, 2005, Pages 625-632

  Elmlinger, Martin W ^a   Kühnel, Werner ^b   Wormstall, Henning ^c   Döller, Peter Claus ^d  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b DPC Academy   (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^d Paul Lechler Krankenhaus   (Germany)

Author keywords

Androgen; Androstenedione; Immunoassay; Reference interval; SHBG; Testosterone

Indexed keywords

ANDROSTENEDIONE; CHORIONIC GONADOTROPIN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADOLESCENT; ADULT; AGED; AGING; ANDROSTENEDIONE BLOOD LEVEL; ARTICLE; AUTOANALYZER; AUTOMATION; BLOOD ANALYSIS; BLOOD SAMPLING; CHEMOLUMINESCENCE; CHILD; DEVELOPMENTAL STAGE; DOWN REGULATION; FEMALE; FOLLOW UP; HORMONE DETERMINATION; HUMAN; HUMAN EXPERIMENT; IMMUNOASSAY; INFANT; MALE; NORMAL HUMAN; ONSET AGE; PUBERTY; REFERENCE VALUE; SEX DIFFERENCE; SEXUAL MATURATION; STEADY STATE; TANDEM MASS SPECTROMETRY; TESTOSTERONE BLOOD LEVEL;

ADOLESCENT; ADULT; AGE FACTORS; AGED; ANDROSTENEDIONE; CHEMILUMINESCENT MEASUREMENTS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; INFANT; INFANT, NEWBORN; MALE; MIDDLE AGED; REFERENCE VALUES; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE;

EID: 28844440803     PISSN: 14336510     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Bourguignon JP Linear growth as a function of age at onset of puberty and sex steroid dosage: therapeutic implications. Endocr Rev. 1988; 9:467-88
2. Rotteveel J, de Ridder C, Schoute E, Delemarre-van de Waal HA. Andro-stenedione, dehydroepiandrosterone sulfate, and estradiol levels throughhout female puberty: relation to height velocity. Horm Res. 1997;48:263-7
3. Mahesh VB, Greenblatt RB. The in vivo conversion of dehydroandrosterone and androstenedione to testosterone in the human. Acta Endocrinol 1962; 41: 400-406
4. Hummer L, Nielsen MD, Christiansen C. An easy and reliable radioimmunoassay of serum androstenedione: age-related normal values in 252 females aged 2 to 70 years. Scand J Clin Lab Invest. 1983; 43:301-6
5. Andersson AM, Juul A, Petersen JH, Muller J, Groome NP, Skakkebaek NE. Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels. J Clin Endocrinol Metab. 1997; 82: 3976-81
6. Gässler N, Peuschel T, Pankau R Pediatric reference values of estradiol, testosterone, lutropin, follitropin and prolactin. Clin Lab. 2000; 46: 553-60
7. Elmlinger MW, Kuhnel W, Ranke MB Reference intervals for serum concentrations of lutropin (LH), follitropin (FSH), estradiol (E2), prolactin, progesterone, sex hormone-binding globuline (SHBG), dehydro-epiandrosterone sulfate (DHEAS), cortisol and ferritin in neonates, children and young adults. Clin Chem Lab Med. 2002 ;40:1151-60
8. Judd HL, Yen SSC. Serum androstendione and testosterone levels during the menstrual cycle. J Clin Endocrinol Metab 1973; 36: 475-81
9. Massafra C, De Felice C, Agnusdei DP, Gioia D, Bagnoli F Androgens and osteocalcin during the menstrual cycle. J Clin Endocrinol Metab. 1999; 84: 971-4
10. Belgorosky A, Rivarola MA. Changes in serum sex hormone-binding globulin and in serum non-sex hormone-binding globulin-bound testosterone during prepuberty in boys. J Steroid Biochem. 1987;27: 291-5
11. Dissaneevate P, Warne GL, Zacharin MR Clinical evaluation in isolated hypogonadotrophic hypogonadism (Kallmann syndrome). J Pediatr Endocrinol Metab. 1998; 11: 631-8
12. Chang RJ. A practical approach to the diagnosis of polycystic ovary syndrome. Am J Obstet Gynecol. 2004;191: 713-7
13. Shifren JL. The role of androgens in female sexual dysfunction. Mayo Clin Proc. 2004; 79:S19-24
14. Kaltsas GA, Korbonits M, Isidori AM, Webb JA, Trainer PJ, Monson JP, Besser GM, Grossman AB How common are polycystic ovaries and the polycystic ovarian syndrome in women with Cushing's syndrome? Clin Endocrinol (Oxf). 2000; 53: 493-500
15. Elmlinger MW, Dengler T, Weinstock C, Kuehnel W. Endocrine alterations in the aging male. Clin Chem Lab Med. 2003;41: 934-41
16. Kaufman JM, Vermeulen A. Declining gonadal function in elderly men. Baillieres Clin Endocrinol Metab 1997; 11: 289-309.
17. Christ-Crain M, Meier C, Huber P, Zimmerli L, Trummler M, Muller B. Comparison of different methods for the measurement of serum testosterone in the aging male. Swiss Med Wkly. 2004 Apr 3;134(13-14):193-7
18. Gruschke A, Kuhl H. Validity of radioimmunological methods for determining free testosterone in serum. Fertil Steril. 2001; 76: 576-82
19. Babson AL, Olson DR, Palmieri T, Ross AF, Becker DM, Mulqueen PJ. The IMMULITE™ Assay tube: a new approach to heterogeneous figarid assay. Clin Chem 1991; 37:1521-9.
20. Rauh M, Gröschl M, Rascher W, Dörr HG. Validation of a tandem mass spectrometry method for plasma 17α-hydroxyprogesterone, 4-androstene-dione and testosterone. Clin Lab Med 2004; 42 (10): A141
21. Cortes-Blanco A, Ferrandez Longas A, Mayayo Dehesa E, Labarta Aizpun JI, Martinez-Lazaro R [Hormonal reference values for adrenocortical function in healthy children from Zaragoza] An Esp Pediatr. 2000;52: 106-115
22. Ismail AA, Walker PL, Macfaul R, Gindal B. Diagnostic value of serum testosterone measurement in infancy: two case reports. Ann Clin Biochem. 1989; 26: 259-61
23. Kratzsch J, Keller E, Hoepffner W, Muller G, Reich A, Meyer K, Kiess W. The DSL analog free testosterone assay: serum levels are not related to sex hormone-binding globulin in normative data throughout childhood and adolescence. Clin Lab. 2001;47: 73-7
24. Gray A, Feldman HA, McKinlay JB, Longeope C. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab 1991; 73: 1016-25.
25. Hallberg MC, Wieland RG, Zorn EM, Furst BH, Wieland JM. Impaired Leydig cell reserve and altered serum androgen binding in the aging male. Fertil Steril 1976; 27: 812-4.
26. Morley JE, Kaiser FE, Perry HM 3rd, Patrick P, Morley PM, Stauber PM, Vellas B, Baumgartner RN, Garry PJ. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism 1997; 46: 410-3.
27. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999; 84: 3666-72.