Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 9, 2007, Pages 3573-3581

  Wierup, Nils ^a   Björkqvist, Maria ^a   Weström, Björn ^b   Pierzynowski, Stefan ^b   Sundler, Frank ^a   Sjölund, Kristina ^c  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; MOTILIN;

ADULT; ARTICLE; BARIATRIC SURGERY; BIOPSY; CANNULA; CELL DENSITY; CELL POPULATION; CLINICAL ARTICLE; DUODENUM; ENDOCRINE CELL; FEMALE; GASTROINTESTINAL TRACT; GASTROSCOPY; HORMONE RELEASE; HUMAN; HUMAN TISSUE; IMMUNOGOLD ELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINE BLOOD FLOW; JEJUNUM; MALE; PHENOTYPE; PRIORITY JOURNAL;

SUIDAE; SUS;

EID: 34548777165     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-2756     Document Type: Article

References (48)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
2. van der Lely AJ, Tschop M, Heiman ML, Ghigo E 2004 Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25:426-457
3. Peeters TL 2005 Ghrelin: a new player in the control of gastrointestinal functions. Gut 54:1638-1649
4. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS 2001 A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50:1714-1719
5. Tschöp M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R, Folwaczny C 2001 Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest 24:RC19-RC21
6. Dornonville de la Cour C, Björkqvist M, Sandvik AK, Bakke I, Zhao CM, Chen D, Håkanson R 2001 A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control. Regul Pept 99:141-150
7. Friis-Hansen L, Wierup N, Rehfeld JF, Sundler F 2005 Reduced ghrelin, islet amyloid polypeptide, and peptide YY expression in the stomach of gastrin-cholecystokinin knockout mice. Endocrinology 146:4464-4471
8. Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka S, Itoh Z, Hosoda H, Kojima M, Kangawa K 2000 Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 276:905-908
9. Dornonville de la Cour C, Lindström E, Norlen P, Håkanson R 2004 Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells. Regul Pept 120:23-32
10. Levin F, Edholm T, Ehrström M, Wallin B, Schmidt PT, Kirchgessner AM, Hilsted LM, Hellström PM, Naslund E 2005 Effect of peripherally administered ghrelin on gastric emptying and acid secretion in the rat. Regul Pept 131:59-65
11. Kitazawa T, De Smet B, Verbeke K, Depoortere I, Peeters TL 2005 Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro. Gut 54:1078-1084
12. Edholm T, Levin F, Hellström PM, Schmidt PT 2004 Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons. Regul Pept 121:25-30
13. Fujino K, Inui A, Asakawa A, Kihara N, Fujimura M, Fujimiya M 2003 Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J Physiol 550:227-240
14. Trudel L, Tomasetto C, Rio MC, Bouin M, Plourde V, Eberling P, Poitras P 2002 Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. Am J Physiol Gastrointest Liver Physiol 282:G948-G952
15. Date Y, Nakazato M, Murakami N, Kojima M, Kangawa K, Matsukura S 2001 Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem Biophys Res Commun 280:904-907
16. De Smet B, Depoortere I, Moechars D, Swennen Q, Moreaux B, Cryns K, Tack J, Buyse J, Coulie B, Peeters TL 2006 Energy homeostasis and gastric emptying in ghrelin knockout mice. J Pharmacol Exp Ther 316:431-439
17. Tack J, Depoortere I, Bisschops R, Delporte C, Coulie B, Meulemans A, Janssens J, Peeters T 2006 Influence of ghrelin on interdigestive gastrointestinal motility in humans. Gut 55:327-333
18. Tack J, Depoortere I, Bisschops R, Verbeke K, Janssens J, Peeters T 2005 Influence of ghrelin on gastric emptying and meal-related symptoms in idiopathic gastroparesis. Aliment Pharmacol Ther 22:847-853
19. Binn M, Albert C, Gougeon A, Maerki H, Coulie B, Lemoyne M, Rabasa Lhoret R, Tomasetto C, Poitras P 2006 Ghrelin gastrokinetic action in patients with neurogenic gastroparesis. Peptides 27:1603-1606
20. Levin F, Edholm T, Schmidt PT, Gryback P, Jacobsson H, Degerblad M, Hoybye C, Holst JJ, Rehfeld JF, Hellström PM, Näslund E 2006 Ghrelin stimulates gastric emptying and hunger in normal-weight humans. J Clin Endocrinol Metab 91:3296-3302
21. Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M 2000 Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141:4255-4261
22. Rindi G, Necchi V, Savio A, Torsello A, Zoli M, Locatelli V, Raimondo F, Cocchi D, Solcia E 2002 Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues. Histochem Cell Biol 117:511-519
23. Moesgaard SG, Ahrén B, Carr RD, Gram DX, Brand CL, Sundler F 2004 Effects of high-fat feeding and fasting on ghrelin expression in the mouse stomach. Regul Pept 120:261-267
24. Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, Suda M, Koh T, Natsui K, Toyooka S, Shirakami G, Usui T, Shimatsu A, Doi K, Hosoda H, Kojima M, Kangawa K, Nakao K 2001 Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 86:4753-4758
25. Popovic V, Miljic D, Pekic S, Pesko P, Djurovic M, Doknic M, Damjanovic S, Micic D, Cvijovic G, Glodic J, Dieguez C, Casanueva FF 2005 Low plasma ghrelin level in gastrectomized patients is accompanied by enhanced sensitivity to the ghrelin-induced growth hormone release. J Clin Endocrinol Metab 90:2187-2191
26. Wierup N, Svensson H, Mulder H, Sundler F 2002 The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul Pept 107:63-69
27. Wierup N, Sundler F 2005 Ultrastructure of islet ghrelin cells in the human fetus. Cell Tissue Res 319:423-428
28. Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L 2004 Ghrelin cells replace insulin-producing β cells in two mouse models of pancreas development. Proc Natl Acad Sci USA 101:2924-2929
29. Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, Madsen OD, Mellitzer G, Gradwohl G, Serup P 2005 Genetic determinants of pancreatic epsilon-cell development. Dev Biol 286:217-224
30. Wierup N, Yang S, McEvilly RJ, Mulder H, Sundler F 2004 Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells. J Histochem Cytochem 52:301-310
31. Sjölund K, Sandén G, Håkanson R, Sundler F 1983 Endocrine cells in human intestine: an immunocytochemical study. Gastroenterology 85:1120-1130
32. Mulder H, Lindh AC, Sundler F 1993 Islet amyloid polypeptide gene expression in the endocrine pancreas of the rat: a combined in situ hybridization and immunocytochemical study. Cell Tissue Res 274:467-474
33. Böttcher G, Alumets J, Håkanson R, Sundler F 1986 Co-existence of glicentin and peptide YY in colorectal L-cells in cat and man. An electron microscopic study. Regul Pept 13:283-291
34. Hayashida T, Murakami K, Mogi K, Nishihara M, Nakazato M, Mondal MS, Horii Y, Kojima M, Kangawa K, Murakami N 2001 Ghrelin in domestic animals: distribution in stomach and its possible role. Domest Anim Endocrinol 21:17-24
35. Sakata I, Nakamura K, Yamazaki M, Matsubara M, Hayashi Y, Kangawa K, Sakai T 2002 Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract. Peptides 23:531-536
36. Tanaka-Shintani M, Watanabe M 2005 Distribution of ghrelin-immunoreactive cells in human gastric mucosa: comparison with that of parietal cells. J Gastroenterol 40:345-349
37. Inui A, Asakawa A, Bowers CY, Mantovani G, Laviano A, Meguid MM, Fujimiya M 2004 Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J 18:439-456
38. Kobayashi S, Iwanaga T, Fujita T, Yanaihara N 1980 Do enterochromaffin (EC) cells contain motilin? Arch Histol Jpn 43:85-98
39. Usellini L, Buchan AM, Polak JM, Capella C, Cornaggia M, Solcia E 1984 Ultrastructural localization of motilin in endocrine cells of human and dog intestine by the immunogold technique. Histochemistry 81:363-368
40. Schmidt PT, Degerblad M, Lindström E, Sundqvist M, Nåslund E, Gillberg PG, Husebye E, Theodorsson E, Hellström PM 2006 Circulating ghrelin levels after food intake during different phases of the migrating motor complex in man. Eur J Clin Invest 36:503-508
41. Xu L, Depoortere I, Tang M, Peeters TL 2001 Identification and expression of the motilin precursor in the guinea pig. FEBS Lett 490:7-10
42. Xu L, Depoortere I, Thielemans L, Huang Z, Tang M, Peeters TL 2003 Sequence, distribution and quantification of the motilin precursor in the cat. Peptides 24:1387-1395
43. Itoh Z, Honda R, Hiwatashi K, Takeuchi S, Aizawa I, Takayanagi R, Couch EF 1976 Motilin-induced mechanical activity in the canine alimentary tract. Scand J Gastroenterol Suppl 39:93-110
44. Itoh Z, Takeuchi S, Aizawa I, Mori K, Taminato T, Seino Y, Imura H, Yanaihara N 1978 Changes in plasma motilin concentration and gastrointestinal contractile activity in conscious dogs. Am J Dig Dis 23:929-935
45. Vantrappen G, Janssens J, Peeters TL, Bloom SR, Christofides ND, Hellemans J 1979 Motilin and the interdigestive migrating motor complex in man. Dig Dis Sci 24:497-500
46. Peeters TL, Vantrappen G, Janssens J 1980 Fasting plasma motilin levels are related to the interdigestive motility complex. Gastroenterology 79:716-719
47. Cuber JC, Laplace JP, Laredo C, Levenez F, Chayvialle JA 1988 Variations of plasma immunoreactive motilin, pancreatic polypeptide, gastrin and somatostatin along the duodenal motility cycle in the pig. Regul Pept 23:27-35
48. Akamizu T, Murayama T, Teramukai S, Miura K, Bando I, Irako T, Iwakura H, Ariyasu H, Hosoda H, Tada H, Matsuyama A, Kojima S, Wada T, Wakatsuki Y, Matsubayashi K, Kawakita T, Shimizu A, Fukushima M, Yokode M, Kangawa K 2006 Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure. J Endocrinol 188:333-344