Role of individual histidines in the pH-dependent global stability of human Chloride intracellular channel 1

Biochemistry

Volumn 51, Issue 5, 2012, Pages 995-1004

  Achilonu, Ikechukwu ^a   Fanucchi, Sylvia ^a   Cross, Megan ^a   Fernandes, Manuel ^a   Dirr, Heini W ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL STABILITIES; CONTRIBUTING FACTOR; CYTOSOLIC; CYTOSOLS; GLOBAL STABILITY; GLOBAL STRUCTURE; HISTIDINE RESIDUES; INTERMEDIATE STATE; INTRACELLULAR CHANNEL; MEMBRANE-BOUND; NATIVE STATE; PH CHANGE; PH DEPENDENCE; PH-DEPENDENT; TOTAL FREE ENERGY; WILD TYPES;

AMINO ACIDS; CHLORINE COMPOUNDS; HYDROGEN BONDS; STABILITY;

PH EFFECTS;

ALANINE; CHLORIDE CHANNEL; CHLORIDE CHANNEL CLIC1; HISTIDINE; PHENYLALANINE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; HYDROGEN BOND; MUTATION; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN UNFOLDING;

AMINO ACID SEQUENCE; CHLORIDE CHANNELS; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR FLUID; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTONS;

EID: 84856752380     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201541w     Document Type: Article

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