Candidate pathway association study in cocaine dependence: The control of neurotransmitter release

World Journal of Biological Psychiatry

Volumn 13, Issue 2, 2012, Pages 126-134

  Fernndez Castillo, Nolia ^a,b   Cormand, Bru ^a,b   Roncero, Carlos ^c,d   Snchez Mora, Cristina ^a,c   Grau Lopez, Lara ^c   Gonzalvo, Begoa ^c   Miquel, Laia ^c   Corominas, Roser ^a,b   Ramos Quiroga, Josep Antoni ^c,d   Casas, Miquel ^c,d   Ribasés, Marta ^c  

^a UNIVERSITY OF BARCELONA   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^c HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Case control association study; Cocaine dependence; NSF; SNARE complex; Synaptic exocytosis

Indexed keywords

COMPLEXIN 1 PROTEIN; COMPLEXIN 2 PROTEIN; COMPLEXIN 3 PROTEIN; COMPLEXIN 4 PROTEIN; MUNC18 PROTEIN; N ETHYLMALEIMIDE SENSITIVE FACTOR; PROTEIN; RAB PROTEIN; SYNAPTOBREVIN 1; SYNAPTOBREVIN 2; SYNAPTOPHYSIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNAPTOTAGMIN I; SYNAPTOTAGMIN II; SYNTAXIN 1A; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CASE CONTROL STUDY; COCAINE DEPENDENCE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROTRANSMITTER RELEASE; SINGLE NUCLEOTIDE POLYMORPHISM; SPAIN;

ADULT; COCAINE-RELATED DISORDERS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; N-ETHYLMALEIMIDE-SENSITIVE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHOTIC DISORDERS; SPAIN; SYNAPTIC TRANSMISSION;

EID: 84856734646     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622975.2010.551406     Document Type: Article

References (77)

1. Ahmed SH, Lutjens R, van der Stap LD, Lekic D, Romano-Spica V, Morales M, et al. 2005. Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction. Proc Natl Acad Sci USA 102(32):11533-11538. (Pubitemid 41153854)
2. Ballon N, Leroy S, Roy C, Bourdel MC, Charles-Nicolas A, Krebs MO, et al. 2006. (AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population. Pharmacogenomics J 6(2):126-130.
3. Ballon N, Leroy S, Roy C, Bourdel MC, Olie JP, Charles-Nicolas A, et al. 2007. Polymorphisms TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3 ' UTR VNTR of the DAT: association with childhood ADHD in male African-Caribbean cocaine dependents? Am J Med Genet B Neuropsychiatr Genet 144B(8):1034-1041. (Pubitemid 350207778)
4. Barszczewski M, Chua JJ, Stein A, Winter U, Heintzmann R, Zilly FE, et al. 2008. A novel site of action for alpha-SNAP in the SNARE conformational cycle controlling membrane fusion. Mol Biol Cell 19(3):776-784. (Pubitemid 351481796)
5. Bomberger JM, Parameswaran N, Hall CS, Aiyar N, Spielman WS. 2005. Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking. J Biol Chem 280(10):9297-9307. (Pubitemid 40409622)
6. Brookes KJ, Knight J, Xu X, Asherson P. 2005. DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters. Am J Med Genet B Neuropsychiatr Genet 139B(1):33-37. (Pubitemid 41552294)
7. Comings DE, Blum K. 2000. Reward deficiency syndrome: genetic aspects of behavioral disorders. Prog Brain Res 126: 325-341. (Pubitemid 35461297)
8. Comings DE, Gonzalez N, Wu S, Saucier G, Johnson P, Verde R, et al. 1999. Homozygosity at the dopamine DRD3 receptor gene in cocaine dependence. Mol Psychiatry 4(5):484-487. (Pubitemid 29497737)
9. Cong M, Perry SJ, Hu LA, Hanson PI, Claing A, Lefkowitz RJ. 2001. Binding of the beta2 adrenergic receptor to N-ethylmale-imide-sensitive factor regulates receptor recycling. J Biol Chem 276(48):45145-45152.
10. Cornish JL, Kalivas P W. 2000. Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction. J Neurosci 20(15):RC89.
11. Cubells JF, Kranzler HR, McCance-Katz E, Anderson GM, Malison RT, Price LH, et al. 2000. A haplotype at the DBH locus, associated with low plasma dopamine beta-hydroxylase activity, also associates with cocaine-induced paranoia. Mol Psychiatry 5(1):56-63. (Pubitemid 30088453)
12. Dackis C, O'Brien C. 2003. Glutamatergic agents for cocaine dependence. Ann NY Acad Sci 1003:328-345. (Pubitemid 38083066)
13. Dackis CA, Lynch KG, Yu E, Samaha FF, Kampman KM, Cornish JW, et al. 2003. Modafinil and cocaine: a double-blind, placebo-controlled drug interaction study. Drug Alcohol Depend 70(1):29-37. (Pubitemid 36385151)
14. De Vries TJ, Schoffelmeer AN. 2005. Cannabinoid CB1 receptors control conditioned drug seeking. Trends Pharmacol Sci 26(8):420-426. (Pubitemid 41039218)
15. De Vries TJ, Shaham Y, Homberg JR, Crombag H, Schuurman K, Dieben J, et al. 2001. A cannabinoid mechanism in relapse to cocaine seeking. Nat Med 7(10):1151-1154. (Pubitemid 33010025)
16. Dewey SL, Chaurasia CS, Chen CE, Volkow ND, Clarkson FA, Porter SP, et al. 1997. GABAergic attenuation of cocaine-induced dopamine release and locomotor activity. Synapse 25(4):393-398. (Pubitemid 27155151)
17. Di Ciano P, Underwood RJ, Hagan JJ, Everitt BJ. 2003. Attenuation of cue-controlled cocaine-seeking by a selective D3 dopamine receptor antagonist SB-277011-A. Neuropsychop-harmacology 28(2):329-338.
18. Dudbridge F. 2003. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25(2):115-121. (Pubitemid 37064867)
19. Fernàndez-Castillo N, Ribasés M, Roncero C, Casas M, Gonza-lvo B, Cormand B. 2010. Association study between the DAT1, DBH and DRD2 genes and cocaine dependence in a Spanish sample. Psychiatr Genet 20(6):317-320.
20. Filip M. 2005. Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats. Pharmacol Rep 57(1):35-46. (Pubitemid 40601539)
21. Filip M, Nowak E, Papla I. 2001. On the role of serotonin2A/2C receptors in the sensitization to cocaine. J Physiol Pharmacol 52(3):471-481. (Pubitemid 32946285)
22. Filip M, Bubar MJ, Cunningham KA. 2004. Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses. J Pharmacol Exp Ther 310(3):1246-1254. (Pubitemid 39108947)
23. First MB, Spitzer RL, Gibbon M, Williams JBW (1997). Structured Clinical Interview for DSM-IV disorders (SCID-IV). Washington, DC: American Psychiatric Press.
24. Freeman WM, Brebner K, Patel KM, Lynch WJ, Roberts DC, Vrana KE. 2002. Repeated cocaine self-administration causes multiple changes in rat frontal cortex gene expression. Neuro-chem Res 27(10):1181-1192. (Pubitemid 35316114)
25. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumen-stiel B, et al. 2002. The structure of haplotype blocks in the human genome. Science 296(5576):2225-2229. (Pubitemid 34680308)
26. Gass JT, Olive MF. 2008. Glutamatergic substrates of drug addiction and alcoholism. Biochem Pharmacol 75(1):218-265. (Pubitemid 350235390)
27. Gonzalez G, Sevarino K, Sofuoglu M, Poling J, Oliveto A, Gonsai K, et al. 2003. Tiagabine increases cocaine-free urines in cocaine-dependent methadone-treated patients: results of a randomized pilot study. Addiction 98(11):1625-1632. (Pubitemid 37373861)
28. Gonzalez JR, Armengol L, Sole X, Guino E, Mercader JM, Estivill X, et al. 2007. SNPassoc: an R package to perform whole genome association studies. Bioinformatics 23(5):644-645. (Pubitemid 46522604)
29. Grucza RA, Wang JC, Stitzel JA, Hinrichs AL, Saccone SF, Sac-cone NL, et al. 2008. A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. Biol Psychiatry 64(11):922-929.
30. Guindalini C, Howard M, Haddley K, Laranjeira R, Collier D, Ammar N, et al. 2006. A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample. Proc Natl Acad Sci USA 103(12):4552-4557.
31. Guindalini C, Laranjeira R, Collier D, Messas G, Vallada H, Breen G. 2008. Dopamine-beta hydroxylase polymorphism and cocaine addiction. Behav Brain Funct 4:1.
32. Hall FS, Li XF, Sora I, Xu F, Caron M, Lesch KP, et al. 2002. Cocaine mechanisms: enhanced cocaine, fluoxetine and nisox-etine place preferences following monoamine transporter deletions. Neuroscience 115(1):153-161. (Pubitemid 35232697)
33. Hall FS, Sora I, Drgonova J, Li XF, Goeb M, Uhl GR. 2004. Molecular mechanisms underlying the rewarding effects of cocaine. Ann NY Acad Sci 1025:47-56. (Pubitemid 39643844)
34. Hart CL, Haney M, Vosburg SK, Rubin E, Foltin RW. 2008. Smoked cocaine self-administration is decreased by modafinil. Neuropsychopharmacology 33(4):761-768. (Pubitemid 351252706)
35. Heydorn A, Sondergaard BP, Hadrup N, Holst B, Haft CR, Schwartz T W. 2004. Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting. FEBS Lett 556(1-3):276-280. (Pubitemid 38058592)
36. Kalivas P W. 2007. Neurobiology of cocaine addiction: implications for new pharmacotherapy. Am J Addict 16(2):71-78. (Pubitemid 46633928)
37. Kalivas PW, O'Brien C. 2008. Drug addiction as a pathology of staged neuroplasticity. Neuropsychopharmacology 33(1): 166-180. (Pubitemid 350191316)
38. Kendler KS, Prescott CA. 1998. Cocaine use, abuse and dependence in a population-based sample of female twins. Br J Psychiatry 173:345-350. (Pubitemid 28454823)
39. Kendler KS, Karkowski LM, Neale MC, Prescott CA. 2000. Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins. Arch Gen Psychiatry 57(3):261-269. (Pubitemid 30140435)
40. Kuhar MJ, Ritz MC, Boja JW. 1991. The dopamine hypothesis of the reinforcing properties of cocaine. Trends Neurosci 14(7): 299-302.
41. Littleton JT, Barnard RJ, Titus SA, Slind J, Chapman ER, Ganetzky B. 2001. SNARE-complex disassembly by NSF follows synaptic-vesicle fusion. Proc Natl Acad Sci USA 98(21):12233-12238. (Pubitemid 32959856)
42. Malcolm R, Swayngim K, Donovan JL, DeVane CL, Elkashef A, Chiang N, et al. 2006. Modafinil and cocaine interactions. Am J Drug Alcohol Abuse 32(4):577-587. (Pubitemid 44870996)
43. Malsam J, Kreye S, Sollner TH. 2008. Membrane fusion: SNAREs and regulation. Cell Mol Life Sci 65(18):2814-2832.
44. Mannelli P, Patkar AA, Murray HW, Certa K, Peindl K, Mattila-Evenden M, et al. 2005. Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals. Addict Biol 10(3): 261-268. (Pubitemid 41306329)
45. Miller SA, Dykes DD, Polesky HF. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16(3):1215.
46. Morgan AE, Dewey SL. 1998. Effects of pharmacologic increases in brain GABA levels on cocaine-induced changes in extracellular dopamine. Synapse 28(1):60-65. (Pubitemid 128770603)
47. Nishimune A, Isaac JT, Molnar E, Noel J, Nash SR, Tagaya M, et al. 1998. NSF binding to GluR2 regulates synaptic transmission. Neuron 21(1):87-97. (Pubitemid 28355694)
48. Noble EP, Blum K, Khalsa ME, Ritchie T, Montgomery A, Wood RC, et al. 1993. Allelic association of the D2 dopamine receptor gene with cocaine dependence. Drug Alcohol Depend 33(3):271-285. (Pubitemid 23306208)
49. O'Brien MS, Anthony JC. 2005. Risk of becoming cocaine dependent: epidemiological estimates for the United States, 2000-2001. Neuropsychopharmacology 30(5):1006-1018. (Pubitemid 40570915)
50. Osten P, Srivastava S, Inman GJ, Vilim FS, Khatri L, Lee LM, et al. 1998. The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha-and beta-SNAPs. Neuron 21(1):99-110. (Pubitemid 28355695)
51. Patkar AA, Berrettini WH, Hoehe M, Hill KP, Sterling RC, Gottheil E, et al. 2001. Serotonin transporter (5-HTT) gene polymorphisms and susceptibility to cocaine dependence among African-American individuals. Addict Biol 6(4):337-345. (Pubitemid 32946749)
52. Pontier SM, Lahaie N, Ginham R, St-Gelais F, Bonin H, Bell DJ, et al. 2006. Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy. Embo J 25(12):2698-2709. (Pubitemid 43980378)
53. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira M, Bender D, et al. 2007. PLINK: a toolset for whole-genome association and population-based linkage analysis. Am J Hum Genet 81(3): 559-575. (Pubitemid 47330214)
54. Rizo J, Rosenmund C. 2008. Synaptic vesicle fusion. Nat Struct Mol Biol 15(7):665-674. (Pubitemid 351932007)
55. Schweizer FE, Dresbach T, DeBello WM, O'Connor V, Augustine GJ, Betz H. 1998. Regulation of neurotransmitter release kinetics by NSF. Science 279(5354):1203-1206. (Pubitemid 28164371)
56. Song I, Kamboj S, Xia J, Dong H, Liao D, Huganir RL. 1998. Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors. Neuron 21(2):393-400. (Pubitemid 28399699)
57. Sora I, Wichems C, Takahashi N, Li XF, Zeng Z, Revay R, et al. 1998. Cocaine reward models: conditioned place preference can be established in dopamine-and in serotonin-transporter knockout mice. Proc Natl Acad Sci USA 95(13):7699-7704. (Pubitemid 28293316)
58. Sora I, Hall FS, Andrews AM, Itokawa M, Li XF, Wei HB, et al. 2001. Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proc Natl Acad Sci USA 98(9):5300-5305. (Pubitemid 32397123)
59. Soria G, Mendizabal V, Tourino C, Robledo P, Ledent C, Par-mentier M, et al. 2005. Lack of CB1 cannabinoid receptor impairs cocaine self-administration. Neuropsychopharmacol-ogy 30(9):1670-1680. (Pubitemid 43086024)
60. Spealman RD. 1993. Modification of behavioral effects of cocaine by selective serotonin and dopamine uptake inhibitors in squirrel monkeys. Psychopharmacology (Berlin) 112(1):93-99. (Pubitemid 23261861)
61. Stephens M, Smith NJ, Donnelly P. 2001. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68(4):978-989. (Pubitemid 32289743)
62. Storey J. 2002. A direct approach to false discovery Rates. J R Stat Soc Ser B 64:479-498.
63. Thomas MJ, Kalivas PW, Shaham Y. 2008. Neuroplasticity in the mesolimbic dopamine system and cocaine addiction. Br J Pharmacol 154(2):327-342. (Pubitemid 351670603)
64. Thorisson GA, Smith AV, Krishnan L, Stein LD. 2005. The International HapMap Project Web site. Genome Res 15(11): 1592-1593. (Pubitemid 41545013)
65. Tsuang MT, Lyons MJ, Meyer JM, Doyle T, Eisen SA, Goldberg J, et al. 1998. Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. Arch Gen Psychiatry 55(11):967-972. (Pubitemid 28506837)
66. Uhl GR, Hall FS, Sora I. 2002. Cocaine, reward, movement and monoamine transporters. Mol Psychiatry 7(1):21-26. (Pubitemid 34087875)
67. Uys JD, LaLumiere RT. 2008. Glutamate: the new frontier in pharmacotherapy for cocaine addiction. CNS Neurol Disord Drug Targets 7(5):482-491.
68. Volkow ND, Wang GJ, Fowler JS, Gatley SJ, Ding YS, Logan J, et al. 1996. Relationship between psychostimulant-induced "high" and dopamine transporter occupancy. Proc Natl Acad Sci USA 93(19):10388-10392.
69. Volkow ND, Fowler JS, Wang GJ. 1999. Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. J Psychopharmacol 13(4):337-345. (Pubitemid 30055177)
70. Volkow ND, Fowler JS, Wang GJ, Goldstein RZ. 2002. Role of dopamine, the frontal cortex and memory circuits in drug addiction: insight from imaging studies. Neurobiol Learn Mem 78(3):610-624. (Pubitemid 36268682)
71. Vorel SR, Ashby CR Jr, Paul M, Liu X, Hayes R, Hagan JJ, et al. 2002. Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats. J Neurosci 22(21):9595-9603. (Pubitemid 35356201)
72. Wagner FA, Anthony JC. 2002. From first drug use to drug dependence; developmental periods of risk for dependence upon marijuana, cocaine, and alcohol. Neuropsychopharma-cology 26(4):479-488. (Pubitemid 34260997)
73. Walsh SL, Cunningham KA. 1997. Serotonergic mechanisms involved in the discriminative stimulus, reinforcing and subjective effects of cocaine. Psychopharmacology (Berlin) 130(1): 41-58. (Pubitemid 27107783)
74. Woolverton WL, Johnson KM. 1992. Neurobiology of cocaine abuse. Trends Pharmacol Sci 13(5):193-200.
75. Xu F, Gainetdinov RR, Wetsel WC, Jones SR, Bohn LM, Miller GW, et al. 2000. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nat Neurosci 3(5): 465-471. (Pubitemid 30495628)
76. Yuferov V, Kroslak T, Laforge KS, Zhou Y, Ho A, Kreek MJ. 2003. Differential gene expression in the rat caudate putamen after "binge" cocaine administration: advantage of triplicate micro-array analysis. Synapse 48(4):157-169. (Pubitemid 36520649)
77. Zuo L, Kranzler HR, Luo X, Yang BZ, Weiss R, Brady K, et al. 2009. Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample. Neuropsychopharmacology 34(6):1504-1513.