Trimer hydroxylated quinone derived from apocynin targets cysteine residues of p47 phox preventing the activation of human vascular NADPH oxidase

Free Radical Biology and Medicine

Volumn 52, Issue 5, 2012, Pages 962-969

  Mora Pale, Mauricio ^a   Joon Kwon, Seok ^a   Linhardt, Robert J ^a,b   Dordick, Jonathan S ^a,b  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

Apocynin derived oligophenols; Enzyme inhibition; Free radicals; Human vascular NADPH oxidase; p22 phox; p47 phox

Indexed keywords

1,2 NAPHTHOQUINONE; 1,4 NAPHTHOQUINONE; APOCYNIN; CYSTEINE; GLYCINE; PROTEIN P22; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE MUTATION; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; SITE DIRECTED MUTAGENESIS;

ACETOPHENONES; ANIMALS; BIOCATALYSIS; CELL SURVIVAL; CELLS, CULTURED; CYSTEINE; ENDOTHELIAL CELLS; ENZYME ACTIVATION; HUMANS; HYDROXYLATION; INHIBITORY CONCENTRATION 50; NADPH OXIDASE; PC12 CELLS; PROTEIN BINDING; QUINONES; RATS; SUPEROXIDES;

EID: 84856717179     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.12.015     Document Type: Article

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