Knockdown of RON inhibits AP-1 activity and induces apoptosis and cell cycle arrest through the modulation of Akt/FoxO signaling in human colorectal cancer cells

Digestive Diseases and Sciences

Volumn 57, Issue 2, 2012, Pages 371-380

  Chung, Cho Yun ^a   Park, Young Lan ^a   Song, Young A ^a   Myung, Eun ^a   Kim, Kyu Yeol ^a   Lee, Gi Hoon ^a   Ki, Ho Seok ^a   Park, Kang Jin ^a   Cho, Sung Bum ^a   Lee, Wan Sik ^a   Jung, Young Do ^a   Kim, Kyung Keun ^a   Joo, Young Eun ^a  

^a Chonnam National University   (South Korea)

Author keywords

Akt; AP 1; Colorectal neoplasm; FoxO; Receptor tyrosine kinase

Indexed keywords

PROTEIN; PROTEIN KINASE B; RECEPTEUR D ORIGINE NANTAIS PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL FUNCTION; COLORECTAL CANCER; GENE SILENCING; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MODULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE CHECKPOINTS; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; GENE KNOCKDOWN TECHNIQUES; HUMANS; NEOPLASM INVASIVENESS; RECEPTOR PROTEIN-TYROSINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED;

EID: 84856711071     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-011-1892-7     Document Type: Article

References (38)

1. Y Lu HP Yao MH Wang 2007 Multiple variants of the RON receptor tyrosine kinase: biochemical properties, tumorigenic activities, and potential drug targets Cancer Lett 257 157 164 17889431 10.1016/j.canlet.2007.08.007 1:CAS:528:DC%2BD2sXhtFGkt7vL (Pubitemid 47538834)
2. MA Leonis MN Thobe SE Waltz 2007 Ron-receptor tyrosine kinase in tumorigenesis and metastasis Future Oncol 3 441 448 17661719 10.2217/14796694.3.4.441 1:CAS:528:DC%2BD2sXot1ylur4%3D (Pubitemid 47250161)
3. ER Camp W Liu F Fan A Yang R Somcio LM Ellis 2005 RON, a tyrosine kinase receptor involved in tumor progression and metastasis Ann Surg Oncol 12 273 281 15827676 10.1245/ASO.2005.08.013 (Pubitemid 40616491)
4. MH Wang HP Yao YQ Zhou 2006 Oncogenesis of RON receptor tyrosine kinase: a molecular target for malignant epithelial cancers Acta Pharmacol Sin 27 641 650 16723080 10.1111/j.1745-7254.2006.00361.x 1:CAS:528:DC%2BD28XmtFeru78%3D (Pubitemid 43943910)
5. MH Wang D Wang YQ Chen 2003 Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinase Carcinogenesis 24 1291 1300 12807733 10.1093/carcin/bgg089 1:CAS:528: DC%2BD3sXmtFKktbc%3D (Pubitemid 37038819)
6. PK Wagh BE Peace SE Waltz 2008 Met-related receptor tyrosine kinase Ron in tumor growth and metastasis Adv Cancer Res 100 1 33 18620091 10.1016/S0065-230X(08)00001-8 1:CAS:528:DC%2BD1cXhtVajsrbJ (Pubitemid 351942429)
7. A Danilkovitch-Miagkova 2003 Oncogenic signaling pathways activated by RON receptor tyrosine kinase Curr Cancer Drug Targets 3 31 40 12570659 10.2174/1568009033333745 1:CAS:528:DC%2BD3sXlsVGntA%3D%3D (Pubitemid 36119419)
8. CT Lee NH Chow PF Su SC Lin PC Lin JC Lee 2008 The prognostic significance of RON and MET coexpression in patients with colorectal cancer Dis Colon Rectum 5 1268 1274 10.1007/s10350-008-9297-1
9. P Maggiora S Marchio MC Stella, et al. 1998 Overexpression of the RON gene in human breast carcinoma Oncogene 16 2927 2933 9671413 10.1038/sj.onc.1201812 1:CAS:528:DyaK1cXjvFSjuro%3D (Pubitemid 28383277)
10. CG Willett MH Wang RL Emanuel, et al. 1998 Macrophage-stimulating protein and its receptor in non-small cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration Am J Respir Cell Mol Biol 18 489 496 9533936 1:CAS:528:DyaK1cXis1Oisbw%3D (Pubitemid 128353622)
11. P Maggiora A Lorenzato S Fracchioli, et al. 2003 The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness Exp Cell Res 288 382 389 12915129 10.1016/S0014-4827(03) 00250-7 1:CAS:528:DC%2BD3sXmt1ehu7w%3D (Pubitemid 36959954)
12. HL Cheng HS Liu YJ Lin, et al. 2005 Coexpression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder Br J Cancer 92 1906 1914 15870710 10.1038/sj.bjc.6602593 1:CAS:528:DC%2BD2MXkt1Sgsrs%3D (Pubitemid 40826140)
13. CP Matthews NH Colburn MR Young 2007 AP-1 a target for cancer prevention Curr Cancer Drug Targets 7 317 324 17979626 10.2174/156800907780809723 1:CAS:528:DC%2BD2sXmsV2msrw%3D (Pubitemid 46849236)
14. E Shaulian 2010 AP-1-The Jun proteins: oncogenes or tumor suppressors in disguise? Cell Signal 22 894 899 20060892 10.1016/j.cellsig.2009.12.008 1:CAS:528:DC%2BC3cXjs1ait70%3D
15. BW Ozanne HJ Spence LC McGarry RF Hennigan 2007 Transcription factors control invasion: AP-1 the first among equals Oncogene 26 1 10 16799638 10.1038/sj.onc.1209759 1:CAS:528:DC%2BD2sXhsFOktQ%3D%3D (Pubitemid 46067326)
16. Z Dong MJ Birrer RG Watts LM Matrisian NH Colburn 1994 Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells Proc Natl Acad Sci USA 91 609 613 8290571 10.1073/pnas.91.2.609 1:CAS:528:DyaK2cXhsFKgu7w%3D (Pubitemid 24041451)
17. MR Young JJ Li M Rincón, et al. 1999 Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion Proc Natl Acad Sci USA 96 9827 9832 10449779 10.1073/pnas.96.17.9827 1:CAS:528:DyaK1MXlsVymtLg%3D (Pubitemid 29398817)
18. JY Yang MC Hung 2009 A new fork for clinical application: targeting forkhead transcription factors in cancer Clin Cancer Res 15 752 757 19188143 10.1158/1078-0432.CCR-08-0124 1:CAS:528:DC%2BD1MXht1Ons7g%3D
19. D Finlay D Cantrell 2010 Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration Ann N Y Acad Sci 1183 149 157 20146713 10.1111/j.1749-6632.2009.05134.x 1:CAS:528:DC%2BC3cXisVehs7o%3D
20. S Reagan-Shaw N Ahmad 2007 The role of Forkhead-box Class O (FoxO) transcription factors in cancer: a target for the management of cancer Toxicol Appl Pharmacol 224 360 368 17275054 10.1016/j.taap.2006.12.003 1:CAS:528:DC%2BD2sXhtF2mtL%2FK (Pubitemid 47575672)
21. EW Lam RE Francis M Petkovic 2006 FOXO transcription factors: key regulators of cell fate Biochem Soc Trans 34 722 726 17052182 10.1042/BST0340722 1:CAS:528:DC%2BD28XhtFWnsLjK (Pubitemid 44796405)
22. K Ito R Bernardi PP Pandolfi 2009 A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell Curr Opin Genet Dev 19 51 59 19216069 10.1016/j.gde.2009.01.004 1:CAS:528:DC%2BD1MXisFKns7s%3D
23. AG Vaiopoulos KK Papachroni AG Papavassiliou 2010 Colon carcinogenesis: learning from NF-kappaB and AP-1 Int J Biochem Cell Biol 42 1061 1065 20348011 10.1016/j.biocel.2010.03.018 1:CAS:528:DC%2BC3cXmslCjt74%3D
24. MC Raff 1992 Social controls on cell survival and cell death Nature 356 397 400 1557121 10.1038/356397a0 1:STN:280:DyaK383ht1Cmtg%3D%3D
25. EF Mason JC Rathmell 2011 Cell metabolism: an essential link between cell growth and apoptosis Biochim Biophys Acta 1813 645 654 20816705 10.1016/j.bbamcr.2010.08.011 1:CAS:528:DC%2BC3MXjsFCgsb8%3D
26. RJ DeBerardinis JJ Lum G Hatzivassiliou CB Thompson 2008 The biology of cancer: metabolic reprogramming fuels cell growth and proliferation Cell Metab 7 11 20 18177721 10.1016/j.cmet.2007.10.002 1:CAS:528:DC%2BD1cXnsFSnsg%3D%3D
27. DO Morgan 1995 Principles of CDK regulation Nature 374 131 134 7877684 10.1038/374131a0 1:CAS:528:DyaK2MXkt1yju7s%3D
28. X Grana EP Reddy 1995 Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs) Oncogene 11 211 219 7624138 1:CAS:528:DyaK2MXnt1Oqurc%3D
29. N Johnson GI Shapiro 2010 Cyclin-dependent kinases (cdks) and the DNA damage response: rationale for cdk inhibitor-chemotherapy combinations as an anticancer strategy for solid tumors Expert Opin Ther Targets 14 1199 1212 20932174 10.1517/14728222.2010.525221 1:CAS:528:DC%2BC3cXht12ns7zK
30. G Song G Ouyang S Bao 2005 The activation of Akt/PKB signaling pathway and cell survival J Cell Mol Med 9 59 71 15784165 10.1111/j.1582-4934.2005. tb00337.x 1:CAS:528:DC%2BD2MXlt1eqtLo%3D
31. Z Li H Yao S Guin SS Padhye YQ Zhou MH Wang 2010 Monoclonal antibody (mAb)-induced down-regulation of RON receptor tyrosine kinase diminishes tumorigenic activities of colon cancer cells Int J Oncol 37 473 482 20596675
32. MH Wang WF Lao D Wang YL Luo HP Yao 2007 Blocking tumorigenic activities of colorectal cancer cells by a splicing RON receptor variant defective in the tyrosine kinase domain Cancer Biol Ther 6 1121 1129 17611409 10.4161/cbt.6.7.4337 1:CAS:528:DC%2BD2sXhsVWksrfF (Pubitemid 351574966)
33. Y Baba K Nosho K Shima, et al. 2011 Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers Cancer 117 1399 1408 21425139 10.1002/cncr.25630 1:CAS:528:DC%2BC3MXkslWiu7s%3D
34. CR McNamara A Degterev 2011 Small-molecule inhibitors of the PI3K signaling network Future Med Chem 3 549 565 21526896 10.4155/fmc.11.12 1:CAS:528:DC%2BC3MXltlejtLc%3D
35. S Kousteni 2011 FoxO1: a molecule for all seasons J Bone Miner Res 26 912 917 21541992 10.1002/jbmr.306 1:CAS:528:DC%2BC3MXmslWlsLY%3D
36. SS Myatt JJ Brosens EW Lam 2011 Sense and sensitivity: FOXO and ROS in cancer development and treatment Antioxid Redox Signal 14 675 687 20649462 10.1089/ars.2010.3383 1:CAS:528:DC%2BC3MXlsFOjuw%3D%3D
37. F Zanella A Carnero 2009 Adding more content to screening: reactivation of FOXO as a therapeutic strategy Clin Transl Oncol 11 651 658 19828407 10.1007/s12094-009-0420-0
38. K Maiese ZZ Chong J Hou YC Shang 2009 The "O" class: crafting clinical care with FoxO transcription factors Adv Exp Med Biol 665 242 260 20429429 10.1007/978-1-4419-1599-3-18 1:CAS:528:DC%2BC3cXhsFOnsLrI