Mulberry leaf extract stimulates glucose uptake and GLUT4 translocation in rat adipocytes

American Journal of Chinese Medicine

Volumn 40, Issue 1, 2012, Pages 163-175

  Naowaboot, Jarinyaporn ^a   Pannangpetch, Patchareewan ^a   Kukongviriyapan, Veerapol ^a   Prawan, Auemduan ^a   Kukongviriyapan, Upa ^a   Itharat, Arunporn ^b  

^a KHON KAEN UNIVERSITY   (Thailand)

^b THAMMASAT UNIVERSITY   (Thailand)

Author keywords

Diabetes Mellitus; Glucose Transporter Protein; Glucose Uptake; Morus alba; Mulberry

Indexed keywords

1 DEOXYNOJIRIMYCIN; DEOXYGLUCOSE; GALLIC ACID; GLUCOSE TRANSPORTER 4; MULBERRY EXTRACT; PHENOL DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; QUERCETIN; WORTMANNIN;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CELL ISOLATION; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; GLUCOSE TRANSPORT; MALE; NONHUMAN; PLANT LEAF; RAT;

ADIPOCYTES; ANDROSTADIENES; ANIMALS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GALLIC ACID; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HYPOGLYCEMIC AGENTS; MALE; MORUS; PHOSPHATIDYLINOSITOL 3-KINASES; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84856649698     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X12500139     Document Type: Article

References (27)

1. Asano, N., T. Yamashita, K. Yasuda, K. Ikeda, H. Kizu, Y. Kameda, A. Kato, R.J. Nash, H.S. Lee and K.S. Ryu. Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J. Agric. Food Chem. 49: 4208-4213, 2001. (Pubitemid 32896411)
2. Bradford, M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976.
3. Burnette, W.N. "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate- polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal. Biochem. 112: 195-203, 1981.
4. Chu, Q., M. Lin, X. Tian and J. Ye. Study on capillary electrophoresis-amperometric detection profiles of different parts of Morus alba L. J. Chromatogr. A 1116: 286-290, 2006.
5. Cushman, S.W. and L.J. Wardzala. Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane. J. Biol. Chem. 255: 4758-4762, 1980. (Pubitemid 10060754)
6. Czech, M.P. Molecular actions of insulin on glucose transport. Annu. Rev. Nutr. 15: 441-471, 1995.
7. Hansen, P.A., W. Wang, B.A. Marshall, J.O. Holloszy and M. Mueckler. Dissociation of GLUT4 translocation and insulin-stimulated glucose transport in transgenic mice overexpressing GLUT1 in skeletal muscle. J. Biol. Chem. 273: 18173-18179, 1998. (Pubitemid 28334736)
8. Hikino, H., T. Mizuno, Y. Oshima and C. Konno. Isolation and hypoglycemic activity of moran A, a glycoprotein of Morus alba root barks. Planta Med. (2): 159-160, 1985.
9. Hsu, C.L. and G.C. Yen. Effect of gallic acid on high fat diet-induced dyslipidaemia, hepatosteatosis and oxidative stress in rats. Br. J. Nutr. 98: 727-735, 2007.
10. Huang, T.H., G. Peng, B.P. Kota, G.Q. Li, J. Yamahara, B.D. Roufogalis and Y. Li. Anti-diabetic action of Punica granatum flower extract: activation of PPAR-gamma and identification of an active component. Toxicol. Appl. Pharmacol. 207: 160-169, 2005. (Pubitemid 41133502)
11. Le Roith, D. and Y. Zick. Recent advances in our understanding of insulin action and insulin resistance. Diabetes Care 24: 588-597, 2001. (Pubitemid 32198431)
12. Lee, J., K. Chae, J. Ha, B.Y. Park, H.S. Lee, S. Jeong, M.Y. Kim and M. Yoon. Regulation of obesity and lipid disorders by herbal extracts from Morus alba, Melissa officinalis, and Artemisia capillaris in high-fat diet-induced obese mice. J. Ethnopharmacol. 115: 263-270, 2008. (Pubitemid 350266269)
13. Marette, A., J.M. Richardson, T. Ramlal, T.W. Balon, M. Vranic, J.E. Pessin and A. Klip. Abundance, localization, and insulin-induced translocation of glucose transporters in red and white muscle. Am. J. Physiol. 263: C443-452, 1992.
14. Miyahara, C., M. Miyazawa, S. Satoh, A. Sakai and S. Mizusaki. Inhibitory effects of mulberry leaf extract on postprandial hyperglycemia in normal rats. J. Sci. Vitaminol. (Tokyo) 50: 161-164, 2004. (Pubitemid 39045117)
15. Musabayane, C.T., P.T. Bwititi and J.A. Ojewole. Effects of oral administration of some herbal extracts on food consumption and blood glucose levels in normal and streptozotocin-treated diabetic rats. Methods Find Exp. Clin. Pharmacol. 28: 223-228, 2006. (Pubitemid 44013392)
16. Naowaboot, J., P. Pannangpetch, V. Kukongviriyapan, B. Kongyingyoes and U. Kukongviriyapan. Antihyperglycemic, antioxidant and antiglycation activities of mulberry leaf extract in strep-tozotocin-induced chronic diabetic rats. Plant Foods Hum. Nutr. 64: 116-121, 2009.
17. Nuengchamnong, N., K. Ingkaninan, W. Kaewruang, S. Wongareonwanakij and B. Hongthongdaeng. Quantitative determination of 1-deoxynojirimycin in mulberry leaves using liquid chromatog-raphy-tandem mass spectrometry. J. Pharm. Biomed. Anal 44: 853-858, 2007. (Pubitemid 47103242)
18. Oku, T., M. Yamada, M. Nakamura, N. Sadamori and S. Nakamura. Inhibitory effects of extractives from leaves of Morus alba on human and rat small intestinal disaccharidase activity. Br. J. Nutr. 95: 933-938, 2006. (Pubitemid 43805380)
19. Pessin, J.E. and A.R. Saltiel. Signaling pathways in insulin action: molecular targets of insulin resistance. J. Clin. Invest. 106: 165-169, 2000. (Pubitemid 30483117)
20. Rodbell, M. Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J. Biol. Chem. 239: 375-380, 1964.
21. Saltiel, A.R. and C.R. Kahn. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414: 799-806, 2001. (Pubitemid 34000783)
22. Stephens, J.M. and P.F. Pilch. The metabolic regulation and vesicular transport of GLUT4, the major insulin-responsive glucose transporter. Endocr. Rev. 16: 529-546, 1995.
23. Summers, S.A., V.P. Yin, E.L. Whiteman, L.A. Garza, H. Cho, R.L. Tuttle and M.J. Birnbaum. Signaling pathways mediating insulin-stimulated glucose transport. Ann. N. Y. Acad. Sci. 892: 169-186, 1999.
24. Turkmen, N., F. Sari, Y.S. Velioglu. Effects of extraction solvents on concentration and antioxidant activity of black and black mate tea polyphenols determined by ferrous tartrate and Folin- Ciocalteu methods. Food Chem. 99: 835-841, 2006. (Pubitemid 43729557)
25. Vannucci, S.J., H. Nishimura, S. Satoh, S.W. Cushman, G.D. Holman and I.A. Simpson. Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine. Biochem. J. 288: 325-330, 1992.
26. Watson, R.T. and J.E. Pessin. Intracellular organization of insulin signaling and GLUT4 translocation. Recent Prog. Res. 56: 175-193, 2001.
27. Wild, S., G. Roglic, A. Green, R. Sicree and H. King. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27: 1047-1053, 2004. (Pubitemid 38579764)