Determination of atomoxetine metabolites in human plasma by liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 885-886, Issue , 2012, Pages 103-108

  Choi, Chang Ik ^a   Bae, Jung Woo ^b   Lee, Hye In ^a   Jang, Choon Gon ^a   Sohn, Uy Dong ^c   Lee, Seok Yong ^a  

^a Sungkyunkwan University   (South Korea)

^b Keimyung University   (South Korea)

^c Chung Ang University   (South Korea)

Author keywords

4 Hydroxyatomoxetine; Human plasma; LC MS MS; N Desmethylatomoxetine; Pharmacokinetics

Indexed keywords

4-HYDROXYATOMOXETINE; ACCEPTABLE LIMIT; ACCURACY AND PRECISION; AMMONIUM FORMATE; ANALYTES; ANALYTICAL METHOD; ATTENTION DEFICIT; CALIBRATION CURVES; CHROMATOGRAPHIC SEPARATIONS; HUMAN PLASMA; HUMAN PLASMAS; INTERNAL STANDARDS; LC-MS/MS; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; LOWER LIMITS; METHYL-T-BUTYL ETHERS; METOPROLOL; MOBILE PHASE; N-DESMETHYLATOMOXETINE; PHARMACOKINETIC STUDIES; PHARMACOLOGICAL ACTIVITY; POSITIVE ION MODE; PRESYNAPTIC; RETENTION TIME; REVERSED PHASE; SELECTIVE INHIBITORS; TANDEM MASS SPECTROMETRY; VALIDATED METHODS;

AMMONIUM COMPOUNDS; BIOMOLECULES; ETHERS; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES; METHANOL; PHARMACOKINETICS;

PLASMA (HUMAN);

4 HYDROXYATOMOXETINE; ATOMOXETINE; DRUG METABOLITE; N DESMETHYLATOMOXETINE; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DRUG DETERMINATION; DRUG TISSUE LEVEL; FLOW RATE; HUMAN; HUMAN TISSUE; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MAXIMUM PLASMA CONCENTRATION; PRIORITY JOURNAL; QUALITY CONTROL; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; MALE; PHENOLS; PHENYL ETHERS; PROPYLAMINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 84856649492     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.12.023     Document Type: Article

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