Disposition and metabolic fate of atomoxetine hydrochloride: Pharmacokinetics, metabolism, and excretion in the Fischer 344 rat and beagle dog

Drug Metabolism and Disposition

Volumn 31, Issue 1, 2003, Pages 88-97

  Mattiuz, Edward L ^a   Ponsler, G Douglas ^a   Barbuch, Robert J ^a   Wood, Paul G ^a   Mullen, John H ^a   Shugert, Richard L ^a   Li, Qimin ^a   Wheeler, William J ^a   Kuo, Fengjiun ^a   Conrad, Preston C ^a   Sauer, John Michael ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYATOMOXETINE; ATOMOXETINE; CARBON 14; CYTOCHROME P450 2D6; DRUG METABOLITE; NORADRENALIN TRANSPORTER; NORATOMOXETINE; PLASMA PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DOG; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DISPOSITION; DRUG HALF LIFE; DRUG METABOLISM; DRUG PROTEIN BINDING; FECES ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE ABSORPTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT; URINARY EXCRETION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; DOGS; FEMALE; MALE; MICROSOMES, LIVER; PROPYLAMINES; RATS; RATS, INBRED F344; SPECIES SPECIFICITY;

ANIMALIA; CANIS FAMILIARIS;

EID: 0038685707     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.31.1.88     Document Type: Article

References (10)

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