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Volumn 80, Issue 2, 2012, Pages 379-386

Synthesis and in vitro anti-tumor activity of novel HPMA copolymer-drug conjugates with potential cell surface targeting property for carcinoma cells

Author keywords

5 Fluorouracil; Cytotoxicity; HPMA copolymer; Hsp47 CBP2 binding peptide; SCC9 cells; Targeted delivery

Indexed keywords

COPOLYMER; FLUOROURACIL; N (2 HYDROXYPROPYL)METHACRYLAMIDE; PEPTIDE;

EID: 84856619301     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.10.020     Document Type: Conference Paper
Times cited : (9)

References (51)
  • 1
    • 0038387494 scopus 로고    scopus 로고
    • 5-Fluorouracil: Mechanisms of action and clinical strategies
    • DOI 10.1038/nrc1074
    • D.B. Longley, D.P. Harkin, and P.G. Johnston 5-Fluorouracil: mechanisms of action and clinical strategies Nat. Rev. Cancer 3 2003 330 338 (Pubitemid 37328853)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.5 , pp. 330-338
    • Longley, D.B.1    Harkin, D.P.2    Johnston, P.G.3
  • 2
    • 0009809146 scopus 로고
    • Biochemistry of cancer (metabolic aspects)
    • R.W. Brockman, and E.P. Anderson Biochemistry of cancer (metabolic aspects) Annu. Rev. Biochem. 32 1963 463 512
    • (1963) Annu. Rev. Biochem. , vol.32 , pp. 463-512
    • Brockman, R.W.1    Anderson, E.P.2
  • 3
    • 0030769244 scopus 로고    scopus 로고
    • Polymeric prodrugs of 5-fluorouracil
    • DOI 10.1016/S0168-3659(97)00048-5, PII S0168365997000485
    • M. Nichifor, E.H. Schach, and L.W. Seyrnour Polymeric prodrugs of 5-fluorouracil J. Control. Release 48 1997 165 178 (Pubitemid 27401975)
    • (1997) Journal of Controlled Release , vol.48 , Issue.2-3 , pp. 165-178
    • Nichifor, M.1    Schacht, E.H.2    Seymour, L.W.3
  • 4
    • 0026466814 scopus 로고
    • Synthesis and antitumor activity of poly(ethylene glycol)s linked to 5-fluorouracil via a urethane or urea bond
    • T. Ouchi, Y. Hagihara, K. Takahashi, Y. Takano, and I. Igarashi Synthesis and antitumor activity of poly(ethylene glycol)s linked to 5-fluorouracil via a urethane or urea bond Drug Des. Discov. 9 1992 93 105
    • (1992) Drug Des. Discov. , vol.9 , pp. 93-105
    • Ouchi, T.1    Hagihara, Y.2    Takahashi, K.3    Takano, Y.4    Igarashi, I.5
  • 5
    • 0002548405 scopus 로고    scopus 로고
    • 5-Fluoropyrimidines
    • B.A. Chabner, D.L. Longo, second ed. Lippincott-Raven Philadelphia, PA
    • J.L. Grem 5-Fluoropyrimidines B.A. Chabner, D.L. Longo, Cancer Chemotherapy and Biotherapy Principles and Practice second ed. 1996 Lippincott-Raven Philadelphia, PA 149 211
    • (1996) Cancer Chemotherapy and Biotherapy Principles and Practice , pp. 149-211
    • Grem, J.L.1
  • 6
    • 0025666730 scopus 로고
    • Metabolism of pyrimidine analogues and their nucleosides
    • G.C. Daher, B.E. Harris, and R.B. Diasio Metabolism of pyrimidine analogues and their nucleosides Pharmacol. Ther. 48 1990 189 222
    • (1990) Pharmacol. Ther. , vol.48 , pp. 189-222
    • Daher, G.C.1    Harris, B.E.2    Diasio, R.B.3
  • 7
    • 0026757191 scopus 로고
    • Drug-polymer conjugates: Potential for improved chemotherapy
    • R. Duncan Drug-polymer conjugates: potential for improved chemotherapy Anticancer Drugs 3 1992 175 210
    • (1992) Anticancer Drugs , vol.3 , pp. 175-210
    • Duncan, R.1
  • 8
    • 0026926609 scopus 로고
    • Conjugates of anticancer agents and polymers: Advantages of macromolecular therapeutics in vivo
    • H. Maeda, L.W. Seymour, and Y. Miyamoto Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo Bioconjug. Chem. 3 1992 351 362
    • (1992) Bioconjug. Chem. , vol.3 , pp. 351-362
    • Maeda, H.1    Seymour, L.W.2    Miyamoto, Y.3
  • 9
    • 0038387390 scopus 로고    scopus 로고
    • The dawning era of polymer therapeutics
    • DOI 10.1038/nrd1088
    • R. Duncan The dawning era of polymer therapeutics Nat. Rev. Drug Discov. 2 2003 347 360 (Pubitemid 37361705)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.5 , pp. 347-360
    • Duncan, R.1
  • 10
    • 75749149269 scopus 로고    scopus 로고
    • HPMA copolymers: Origins, early developments, present, and future
    • J. Kopeček, and P. Kopečková HPMA copolymers: origins, early developments, present, and future Adv. Drug Deliv. Rev. 62 2010 122 149
    • (2010) Adv. Drug Deliv. Rev. , vol.62 , pp. 122-149
    • Kopeček, J.1    Kopečková, P.2
  • 11
    • 0041962221 scopus 로고    scopus 로고
    • 2-targeted conjugates and combined therapy with immunomodulators
    • DOI 10.1016/S0168-3659(99)00140-6, PII S0168365999001406
    • B. Ríhová, M. Jelínková, J. Strohalm, V. Subr, D. Plocová, O. Hovorka, M. Novák, D. Plundrová, Y. Germano, and K. Ulbrich Polymeric drugs based on conjugates of synthetic and natural macromolecules. II. Anti-cancer activity of antibody or (Fab′)(2)-targeted conjugates and combined therapy with immunomodulators J. Control. Release 64 2000 241 261 (Pubitemid 30035323)
    • (2000) Journal of Controlled Release , vol.64 , Issue.1-3 , pp. 241-261
    • Rihova, B.1    Jelinkova, M.2    Strohalm, J.3    Subr, V.4    Plocova, D.5    Hovorka, O.6    Novak, M.7    Plundrova, D.8    Germano, Y.9    Ulbrich, K.10
  • 12
    • 33745703563 scopus 로고    scopus 로고
    • Polymer therapeutics: Concepts and applications
    • DOI 10.1002/anie.200502113
    • R. Haag, and F. Kratz Polymer therapeutics: concepts and applications Angew. Chem. Int. Ed. Engl. 45 2006 1198 1215 (Pubitemid 44097641)
    • (2006) Angewandte Chemie - International Edition , vol.45 , Issue.8 , pp. 1198-1215
    • Haag, R.1    Kratz, F.2
  • 13
    • 0035904966 scopus 로고    scopus 로고
    • Targeted drug conjugates: Principles and progress
    • DOI 10.1016/S0169-409X(01)00227-7, PII S0169409X01002277
    • M.C. Garnett Targeted drug conjugates: principles and progress Adv. Drug Deliv. Rev. 53 2001 171 216 (Pubitemid 33135563)
    • (2001) Advanced Drug Delivery Reviews , vol.53 , Issue.2 , pp. 171-216
    • Garnett, M.C.1
  • 16
    • 0017641887 scopus 로고
    • Soluble biomedical polymers
    • J. Kopeček Soluble biomedical polymers Polim. Med. 7 1977 191 221
    • (1977) Polim. Med. , vol.7 , pp. 191-221
    • Kopeček, J.1
  • 17
    • 0041616687 scopus 로고
    • Synthesis and activity of a polymer which contains insulin covalently bound on a copolymer of N-(2-hydroxypropyl)methacrylamide and N-methacryloyldiglycyl p-nitrophenyl ester
    • V. Chytrý, A. Vrána, and J. Kopeček Synthesis and activity of a polymer which contains insulin covalently bound on a copolymer of N-(2-hydroxypropyl)methacrylamide and N-methacryloyldiglycyl p-nitrophenyl ester Makromol. Chem. 179 1978 329 336
    • (1978) Makromol. Chem. , vol.179 , pp. 329-336
    • Chytrý, V.1    Vrána, A.2    Kopeček, J.3
  • 18
    • 0002198931 scopus 로고
    • Preparation of polymerizable derivatives of N-(4-aminobenzenesulfonyl)- n′-butylurea
    • B. Obereigner, M. Burešová, A. Vrána, and J. Kopeček Preparation of polymerizable derivatives of N-(4- aminobenzenesulfonyl)-n′-butylurea J. Polym. Sci.: Polym. Symp. 66 1979 41 52
    • (1979) J. Polym. Sci.: Polym. Symp. , vol.66 , pp. 41-52
    • Obereigner, B.1    Burešová, M.2    Vrána, A.3    Kopeček, J.4
  • 19
    • 0041181628 scopus 로고    scopus 로고
    • HPMA copolymer-anticancer drug conjugates: Design, activity, and mechanism of action
    • DOI 10.1016/S0939-6411(00)00075-8, PII S0939641100000758
    • J. Kopeček, P. Kopečková, T. Minko, and Z. Lu HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action Eur. J. Pharm. Biopharm. 50 2000 61 81 (Pubitemid 30326689)
    • (2000) European Journal of Pharmaceutics and Biopharmaceutics , vol.50 , Issue.1 , pp. 61-81
    • Kopecek, J.1    Kopeckova, P.2    Minko, T.3    Lu, Z.-R.4
  • 20
    • 0024243003 scopus 로고
    • Cleavage of oligopeptide side-chains in N-(2-hydroxypropyl)methacrylamide copolymers by mixtures of lysosomal enzymes
    • DOI 10.1016/0168-3659(88)90039-9
    • V. Šubr, J. Kopeček, J. Pohl, M. Baudyš, and V. Kostka Cleavage of oligopeptide side-chains in N-(2-hydroxpropyl)meth-acrylamide copolymers by mixtures of lysosomal enzymes J. Control. Release 8 1988 133 140 (Pubitemid 19010920)
    • (1988) Journal of Controlled Release , vol.8 , Issue.2 , pp. 133-140
    • Subr, V.1    Kopecek, J.2    Pohl, J.3    Baudys, M.4    Kostka, V.5
  • 22
    • 0023450012 scopus 로고
    • Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats
    • L.W. Seymour, R. Duncan, J. Strohalm, and J. Kopeček Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats J. Biomed. Mater. Res. 21 1987 1341 1358
    • (1987) J. Biomed. Mater. Res. , vol.21 , pp. 1341-1358
    • Seymour, L.W.1    Duncan, R.2    Strohalm, J.3    Kopeček, J.4
  • 23
    • 3242715122 scopus 로고    scopus 로고
    • Technetium-99m-labeled N-(2-Hydroxypropyl) methacrylamide copolymers: Synthesis, characterization, and in vivo biodistribution
    • DOI 10.1023/B:PHAM.0000033001.49737.b7
    • A. Mitra, A. Nan, H. Ghandehari, E. McNeill, J. Mulholland, and B.R. Line Technetium-99m-labeled N-(2-hydroxypropyl) methacrylamide copolymers: synthesis, characterization, and in vivo biodistribution Pharm. Res. 21 2004 1153 1159 (Pubitemid 38954199)
    • (2004) Pharmaceutical Research , vol.21 , Issue.7 , pp. 1153-1159
    • Mitra, A.1    Nan, A.2    Ghandehari, H.3    McNeil, E.4    Mulholland, J.5    Line, B.R.6
  • 25
    • 0141615972 scopus 로고    scopus 로고
    • Clinical implications of N-(2-hydroxypropyl)methacrylamide copolymers
    • DOI 10.2174/1389201033489711
    • B. Rihova, and K. Kubackova Clinical implications of N-(2-hydroxypropyl) methacrylamide copolymers Curr. Pharm. Biotechnol. 4 2003 311 322 (Pubitemid 37220863)
    • (2003) Current Pharmaceutical Biotechnology , vol.4 , Issue.5 , pp. 311-322
    • Rihova, B.1    Kubackova, K.2
  • 28
    • 0024243086 scopus 로고
    • Synthesis and anti-tumor activity of vinyl polymers containing 5 fluorouracils attached via carbamoyl bonds to organosilicon groups
    • DOI 10.1016/0168-3659(88)90040-5
    • T. Ouchi, K. Hagita, M. Kwashima, T. Inoi, and T. Tahiro Synthesis and antitumor activity of vinyl polymers containing 5-fluorouracils attached via carbamoyl bonds to organosilicon groups J. Control. Release 8 1988 141 150 (Pubitemid 19011667)
    • (1988) Journal of Controlled Release , vol.8 , Issue.2 , pp. 141-150
    • Ouchi, T.1    Hagita, K.2    Kwashima, M.3    Inoi, T.4    Tashiro, T.5
  • 30
    • 0025135789 scopus 로고
    • Synthesis and antitumor activity of poly(L-cysteine) bonded covalently 5-fluorouracil
    • F. Yang, and R. Zhuo Synthesis and antitumor activity of poly(l-cysteine) bonded covalently 5-fluorouracil Polym. J. 22 1990 572 577 (Pubitemid 20733169)
    • (1990) Polymer Journal , vol.22 , Issue.7 , pp. 572-577
    • Yang Fushun1    Zhuo Renxi2
  • 31
    • 0025984418 scopus 로고
    • Synthesis and antitumor activity of α-1,4-polygalactosamine and N-acetyl-α-1,4-polygalactosamine immobilized 5-fluorouracils through hexamethylene spacer groups via urea, urea bonds
    • Y. Ohya, T.Z. Huang, T. Ouchi, K. Hasegawa, J. Tamura, K. Kadowaki, T. Matumoto, S. Suzuki, and M. Suzuki Synthesis and antitumor activity of α-1,4-polygalactosamine and N-acetyl-α-1,4-polygalactosamine immobilized 5-fluorouracils through hexamethylene spacer groups via urea, urea bonds J. Control. Release 17 1991 259 266
    • (1991) J. Control. Release , vol.17 , pp. 259-266
    • Ohya, Y.1    Huang, T.Z.2    Ouchi, T.3    Hasegawa, K.4    Tamura, J.5    Kadowaki, K.6    Matumoto, T.7    Suzuki, S.8    Suzuki, M.9
  • 32
    • 0026593832 scopus 로고
    • Synthesis and antitumor activity of 6-O-carboxymethyl chitin fixing 5-fluorouracils through pentamethylene, monomethylene spacer groups via amide, ester bonds
    • Y. Ohya, K. Inosaka, and T. Ouchi Synthesis and antitumor activity of 6-O-carboxymethyl chitin fixing 5-fluorouracils through pentamethylene, monomethylene spacer groups via amide, ester bonds Chem. Pharm. Bull. 40 1992 559 561
    • (1992) Chem. Pharm. Bull. , vol.40 , pp. 559-561
    • Ohya, Y.1    Inosaka, K.2    Ouchi, T.3
  • 33
    • 0029339453 scopus 로고
    • Enantioselective release of 5-fluorouracil from N-(2-hydroxypropyl) methacrylamide-based copolymers via lysosomal enzymes
    • D. Putnam, and J. Kopeček Enantioselective release of 5-fluorouracil from N-(2-hydroxypropyl)methacrylamide-based copolymers via lysosomal enzymes Bioconjug. Chem. 6 1995 483 492
    • (1995) Bioconjug. Chem. , vol.6 , pp. 483-492
    • Putnam, D.1    Kopeček, J.2
  • 35
    • 54949139950 scopus 로고    scopus 로고
    • In vitro cytotoxicity, in vivo biodistribution and antitumor activity of HPMA copolymer-5-fluorouracil conjugates
    • F. Yuan, X. Qin, D. Zhou, Q.Y. Xiang, M.T. Wang, Z.R. Zhang, and Y. Huang In vitro cytotoxicity, in vivo biodistribution and antitumor activity of HPMA copolymer-5-fluorouracil conjugates Eur. J. Pharm. Biopharm. 70 2008 770 776
    • (2008) Eur. J. Pharm. Biopharm. , vol.70 , pp. 770-776
    • Yuan, F.1    Qin, X.2    Zhou, D.3    Xiang, Q.Y.4    Wang, M.T.5    Zhang, Z.R.6    Huang, Y.7
  • 36
    • 0034046487 scopus 로고    scopus 로고
    • Binding motifs of CBP2 a potential cell surface target for carcinoma cells
    • DOI 10.1002/(SICI)1097-4644(20000801)78:2<251::AID-JCB8>3.0.CO;2-G
    • J.J. Sauk, R.D. Coletta, K. Norris, and C. Hebert Binding motifs of CBP2 a potential cell surface target for carcinoma cells J. Cell. Biochem. 78 2000 251 263 (Pubitemid 30415902)
    • (2000) Journal of Cellular Biochemistry , vol.78 , Issue.2 , pp. 251-263
    • Sauk, J.J.1    Coletta, R.D.2    Norris, K.3    Hebert, C.4
  • 37
    • 0034993013 scopus 로고    scopus 로고
    • Non-natural CBP2 binding peptides and peptomers modulate carcinoma cell adhesion and invasion
    • C. Hebert, R.D. Coletta, K. Norris, N. Nikitakis, M. Lopes, and J.J. Sauk Non-natural CBP2 binding peptides and peptomers modulate carcinoma cell adhesion and invasion J. Cell. Biochem. 82 2001 145 154
    • (2001) J. Cell. Biochem. , vol.82 , pp. 145-154
    • Hebert, C.1    Coletta, R.D.2    Norris, K.3    Nikitakis, N.4    Lopes, M.5    Sauk, J.J.6
  • 39
    • 0000932483 scopus 로고
    • Aminolyses of monomeric and polymeric p-nitrophenyl esters of methacryloylated amino acids
    • P. Rejmanova, J. Labsky, and J. Kopeček Aminolyses of monomeric and polymeric p-nitrophenyl esters of methacryloylated amino acids Makromol. Chem. 178 1977 2159 2168
    • (1977) Makromol. Chem. , vol.178 , pp. 2159-2168
    • Rejmanova, P.1    Labsky, J.2    Kopeček, J.3
  • 40
    • 0342316475 scopus 로고    scopus 로고
    • Polymeric drugs based on conjugates of synthetic and natural macromolecules. I. Synthesis and physico-chemical characterisation
    • DOI 10.1016/S0168-3659(99)00141-8, PII S0168365999001418
    • K. Ulbrich, V. Šubr, J. Strohalm, D. Plocová, M. Jelínková, and B. Říhová Polymeric drugs based on conjugates of synthetic and natural macromolecules: I. Synthesis and physico-chemical characterization J. Control. Release 64 2000 63 79 (Pubitemid 30035308)
    • (2000) Journal of Controlled Release , vol.64 , Issue.1-3 , pp. 63-79
    • Ulbrich, K.1    Subr, V.2    Strohalm, J.3    Plocova, D.4    Jelinkova, M.5    Rihova, B.6
  • 41
    • 0032580444 scopus 로고    scopus 로고
    • Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate
    • DOI 10.1016/S0168-3659(97)00235-6, PII S0168365997002356
    • V. Omelyanenko, P. Kopečková, C. Gentry, and J. Kopeček Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate J. Control. Release 53 1998 25 37 (Pubitemid 28218687)
    • (1998) Journal of Controlled Release , vol.53 , Issue.1-3 , pp. 25-37
    • Omelyanenko, V.1    Kopeckova, P.2    Gentry, C.3    Kopecek, J.4
  • 42
    • 0001319102 scopus 로고
    • N-(2-hydroxypropyl) methacrylamide copolymers containing pendant saccharide moieties: Synthesis and bioadhesive properties
    • R.C. Rathi, P. Kopečková, B. Říhová, and J. Kopeček N-(2-hydroxypropyl) methacrylamide copolymers containing pendant saccharide moieties: synthesis and bioadhesive properties J. Polym. Sci. Part A: Polym. Chem. 29 1991 1895 1902
    • (1991) J. Polym. Sci. Part A: Polym. Chem. , vol.29 , pp. 1895-1902
    • Rathi, R.C.1    Kopečková, P.2    Říhová, B.3    Kopeček, J.4
  • 43
    • 0030042022 scopus 로고    scopus 로고
    • HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 1. Influence of the method of synthesis on the binding affinity to OVCAR-3 ovarian carcinoma cells in vitro
    • V. Omelyanenko, P. Kopečková, C. Gentry, J.G. Shiah, and J. Kopeček HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 1. Influence of the method of synthesis on the binding affinity to OVCAR-3 ovarian carcinoma cells in vitro J. Drug Target. 3 1996 357 373 (Pubitemid 26059826)
    • (1996) Journal of Drug Targeting , vol.3 , Issue.5 , pp. 357-373
    • Omelyanenko, V.1    Kopeckova, P.2    Gentry, C.3    Shiah, J.-G.4    Kopecek, J.5
  • 44
    • 0024595042 scopus 로고
    • Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
    • DOI 10.1016/0022-1759(89)90397-9
    • M.B. Hansen, S.E. Nielsen, and K. Berg Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill J. Immunol. Methods 119 1989 203 210 (Pubitemid 19132276)
    • (1989) Journal of Immunological Methods , vol.119 , Issue.2 , pp. 203-210
    • Hansen, M.B.1    Nielsen, S.E.2    Berg, K.3
  • 45
    • 0345367901 scopus 로고    scopus 로고
    • HPMA copolymer bound adriamycin overcomes MDR1 gene encoded resistance in a human ovarian carcinoma cell line
    • DOI 10.1016/S0168-3659(98)00009-1, PII S0168365998000091
    • T. Minko, P. Kopečeková, V. Pozharov, and J. Kopeček HPMA copolymer bound adriamycin overcomes MDR1 gene encoded resistance in a human ovarian carcinoma cell line J. Control. Release 54 1998 223 233 (Pubitemid 28342701)
    • (1998) Journal of Controlled Release , vol.54 , Issue.2 , pp. 223-233
    • Minko, T.1    Kopeckova, P.2    Pozharov, V.3    Kopecek, J.4
  • 46
    • 60749108001 scopus 로고    scopus 로고
    • Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect. European
    • H. Maeda, G.Y. Bharate, and J. Daruwalla Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect. European J. Pharm. Biopharm. 71 2009 409 419
    • (2009) J. Pharm. Biopharm. , vol.71 , pp. 409-419
    • Maeda, H.1    Bharate, G.Y.2    Daruwalla, J.3
  • 48
    • 71949127454 scopus 로고    scopus 로고
    • Biodistribution of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer drug delivery
    • M.P. Borgman, O. Aras, S. Geyser-Stoops, E.A. Sausville, and H. Ghandehari Biodistribution of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer drug delivery Mol. Pharm. 6 2009 1836 1847
    • (2009) Mol. Pharm. , vol.6 , pp. 1836-1847
    • Borgman, M.P.1    Aras, O.2    Geyser-Stoops, S.3    Sausville, E.A.4    Ghandehari, H.5
  • 49
    • 78651304180 scopus 로고    scopus 로고
    • HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer
    • N. Larson, A. Ray, A. Malugin, D.B. Pike, and H. Ghandehari HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer Pharm. Res. 27 2010 2683 2693
    • (2010) Pharm. Res. , vol.27 , pp. 2683-2693
    • Larson, N.1    Ray, A.2    Malugin, A.3    Pike, D.B.4    Ghandehari, H.5
  • 50
    • 18744371882 scopus 로고    scopus 로고
    • Water-soluble polymers for targeted drug delivery to human squamous carcinoma of head and back
    • DOI 10.1080/10611860500065187
    • A. Nan, H. Ghandehari, C. Hebert, H. Siavash, N. Nikitakis, M. Reynolds, and J.J. Sauk Water-soluble polymers for targeted drug delivery to human squamous carcinoma of head and neck J. Drug Target. 13 2005 189 197 (Pubitemid 40668172)
    • (2005) Journal of Drug Targeting , vol.13 , Issue.3 , pp. 189-197
    • Nan, A.1    Ghandehari, H.2    Hebert, C.3    Siavash, H.4    Nikitakis, N.5    Reynolds, M.6    Sauk, J.J.7
  • 51
    • 77956171431 scopus 로고    scopus 로고
    • Biological effects and comparative cytotoxicity of thermal transformed asbestos-containing materials in a human alveolar epithelial cell line
    • F. Giantomassi, A.F. Gualtieri, L. Santarelli, M. Tomasetti, G. Lusvardi, G. Lucarini, M. Governa, and A. Pugnaloni Biological effects and comparative cytotoxicity of thermal transformed asbestos-containing materials in a human alveolar epithelial cell line Toxicol. in Vitro 24 2010 1521 1531
    • (2010) Toxicol. in Vitro , vol.24 , pp. 1521-1531
    • Giantomassi, F.1    Gualtieri, A.F.2    Santarelli, L.3    Tomasetti, M.4    Lusvardi, G.5    Lucarini, G.6    Governa, M.7    Pugnaloni, A.8


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