In vitro inhibition of cytochrome P450-mediated reactions by gemfibrozil, erythromycin, ciprofloxacin and fluoxetine in fish liver microsomes

Aquatic Toxicology

Volumn 109, Issue , 2012, Pages 259-266

  Smith, Emily M ^a   Iftikar, Fathima I ^a   Higgins, Sarah ^a   Irshad, Anam ^a   Jandoc, Racquel ^a   Lee, Matthew ^a   Wilson, Joanna Y ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Ciprofloxacin; Cytochrome P450; Enzyme inhibition; Erythromycin; Fluoxetine; Gemfibrozil

Indexed keywords

BETA NAPHTHOFLAVONE; CIPROFLOXACIN; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 1B1; CYTOCHROME P450 1C1; CYTOCHROME P450 1C2; ERYTHROMYCIN; FLUOXETINE; GEMFIBROZIL; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

CYTOCHROME; DRUG; ENZYME ACTIVITY; FISH; INHIBITION;

ANIMAL CELL; ANIMAL EXPERIMENT; AQUATIC ENVIRONMENT; ARTICLE; BIOLOGICAL MONITORING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENVIRONMENTAL IMPACT ASSESSMENT; ENVIRONMENTAL MONITORING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAINBOW TROUT;

ANIMALS; CIPROFLOXACIN; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; ERYTHROMYCIN; FISH PROTEINS; FLUOXETINE; GEMFIBROZIL; MICROSOMES, LIVER; ONCORHYNCHUS MYKISS; WATER POLLUTANTS, CHEMICAL; ZEBRAFISH;

DANIO RERIO; MAMMALIA; ONCORHYNCHUS MYKISS;

EID: 84856618895     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2011.08.022     Document Type: Article

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