Inhibition of cytochrome P450 enzymes by enrofloxacin in the sea bass (Dicentrarchus labrax)

Aquatic Toxicology

Volumn 62, Issue 1, 2003, Pages 27-33

  Vaccaro, E ^a   Giorgi, M ^b   Longo, V ^a   Mengozzi, G ^b   Gervasi, P G ^a  

^a Istituto di Clinica Medica II   (Italy)

^b Dipartimento di Clinica Veterinaria   (Italy)

Author keywords

Cytochrome P450 inhibition; Enrofloxacin metabolism; Sea bass

Indexed keywords

6 BETA TESTOSTERONE HYDROXYLASE; 7 ETHOXYCOUMARIN; AMINOPHENAZONE; CIPROFLOXACIN; CYTOCHROME P450; ENROFLOXACIN; ENZYME; ERYTHROMYCIN; ETHOXYRESORUFIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

INHIBITION;

AQUACULTURE; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; EUROPEAN SEA BASS; FISH; IMMUNOBLOTTING; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTI-INFECTIVE AGENTS; AQUACULTURE; BASS; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOROQUINOLONES; ISOENZYMES; MICROSOMES, LIVER; QUINOLONES;

DICENTRARCHUS; DICENTRARCHUS LABRAX; SALMONIDAE; SERRANIDAE; STAPHYLOCOCCUS PHAGE 3A;

EID: 12244259736     PISSN: 0166445X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-445X(02)00064-4     Document Type: Article

References (30)

1. Baldwin S.J., Bloomer J.C., Smith G.J., Ayrton A.D., Clarke S.E., Chenery R.J. Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9. Xenobiotica. 25:1995;261-270.
2. Bergan T., Dalhoff A., Rohwedder R. Pharmacokinetics of ciprofloxacin. Infection. 16:1988;3-13.
3. Brown S.A. Fluoroquinolones in animal health. J. Vet. Pharmacol. Therap. 19:1996;1-14.
4. Fuhr U., Wolff T., Harder S., Schymanski P., Staib A.H. Quinolone inhibition of cytochrome P450 dependent caffeine metabolism in human liver microsomes. Drug Metab. Dispos. 18:1990;1005-1010.
5. Intorre L., Mengozzi G., Bertini S., Bagliacca M., Luchetti E., Soldani G. The plasma kinetics and tissue distribution of enrofloxacin and its metabolite ciprofloxacin in the muscovy duck. Vet. Res. Commun. 21:1997;127-136.
6. Intorre L., Cecchini S., Bertini S., Cognetti Varriale A.M., Soldani G., Mengozzi G. Pharmacokinetics of enrofloxacin in the sea bass (Dicentrarchus labrax). Aquaculture. 182:2000;49-59.
7. Krijgsheld K.R., Gram T.E. Selective induction of renal microsomal cytochrome P450-linked monooxygenases by 1,1-dichloroethylene in mice. Biochem. Pharmacol. 33:1984;1951-1956.
8. Kullman S.W., Hamm J.T., Hinton D.E. Identification and characterization of a cDNA encoding cytochrome P450 3A from the fresh water teleost medaka (Oryzias latipes). Arch. Biochem. Biophys. 380:2000;29-38.
9. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
10. Lewbart G., Vaden S., Deen J., Manaugh C., Whitt D., Doi A., Smith T., Flammer K. Pharmacokinetics of enrofloxacin in the red pacu (Colossoma brachypomum) after intramuscolar, oral and bath administration. J. Vet. Pharmacol. Therap. 20:1997;124-128.
11. Longo V., Mazzaccaro A., Naldi F., Gervasi P.G. Drug metabolizing enzymes in liver, olfactory and respiratory epithelium of cattle. J. Biochem. Toxicol. 6:1991;123-128.
12. Lowry O.H., Rosebrough N.J., Fart A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
13. Mayeaux M.H., Winston G.H. Antibiotic effects on cytochrome P450 content and mixed-function oxygenase (MFO) activities in the American alligator. Alligator mississippiensis. J. Vet. Pharmacol. Therap. 21:1998;274-281.
14. Mclellan R.A., Drobitch R.K., Monshouwer M., Renton K.W. Fluoroquinolones antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human. Drug Metab. Dispos. 24:1996;1134-1138.
15. Mengozzi G., Intorre L., Bertini S., Soldani. Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intravenous and intramuscolar administration in sheep. Am. J. Vet. Res. 57:1996;1040-1043.
16. Miranda C.L., Wang J.L., Henderson M.C., Buhler D.R. Purification and characterization of hepatic steroid hydroxylases from untreated rainbow trout. Arch. Biochem. Biophys. 268:1989;227-238.
17. Miranda C.L., Henderson M.C., Buhler D.R. Evaluation of chemicals as inhibitors of trout cytochrome P450s. Toxicol. Appl. Pharmacol. 148:1998;237-244.
18. Novi S., Pretti C., Cognetti A.M., Longo V., Marchetti S., Gervasi P.G. Biotransfonnation enzymes and their induction by β-naphtoflavone in adult sea bass (Dicentrarchus labrax). Aquatic Toxicol. 41:1998;63-81.
19. Omura T., Sato R. The carbon-monoxide binding protein of liver microsomes. I. Evidences for its hemoprotein nature. J. Biol. Chem. 293:1964;2370-2378.
20. Platt K.L., Molitor E., Dohemer J., Dogra S., Oesch F. Genetically engineered V79 Chinese hamster cell expression of purified cytochrome P450IIB1 monooxygenase activity. J. Biochem. Toxicol. 4:1989;1-6.
21. Puccini P., Fiorio R., Longo V., Gervasi P.G. High affinity di-ethylnitrosamine-deethylase in liver microsomes from acetone induced rats. Carcinogenesis. 10:1989;1629-1634.
22. Schlosberg A., Ershov E., Bellaiche M., Hanji V., Weisman Y., Soback S. The effects of enrofloxacin on hepatic microsomal mixed function oxidase in broiler chickens. J. Vet. Pharmacol. Therap. 18:1995;311-313.
23. Schnick R.A. An overview of current programs on drug development and regulation for aquaculture: US fish and wildlife service perspective. Vet. Hum. Toxicol. 33:(Suppl):1991;4-5.
24. Stegeman J.J., Hahn M.E. Biochemistry and molecular biology of monooxygenases: current perspectives on farms, functions and regulation of cytochrome P-450 in aquatic species. Malins D.C., Ostrander G.K. Aquatic Toxicology: Molecular, Biochemical and Cellular Perspectives. 1994;87-206 CRC Press, Boca Raton, FL.
25. Stoffregen D.A., Wooster G.A., Bustos P.S., Browser P.R., Babish J.G. Multiple route and dose pharmacokinetics of enrofloxacin in juvenile Atlantic salmon. J. Vet. Pharmacol. Therap. 20:1997;111-123.
26. Taavitsainen P., Juvonen R., Pelkonen O. In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene. Drug Metab. Dispos. 29:2001;217-222.
27. Tu Y.Y., Yang C.S. High-affinity nitrosamine dealkylase system in rat liver microsomes and its induction by fasting. Cancer Res. 43:1983;623-629.
28. Tullman R.H., Hanzlik R.R. Inactivation of cytochrome P-450 and monoamine oxidase by cyclopropylamines. Drug Metab. Rev. 15:1984;1163-1182.
29. Tyczkowska K., Hedeen K.M., Aucoin D.P., Aronson A.L. High performance liquid chromatographic method for the simultaneous determination of enrofloxacin and its primary metabolite ciprofloxacin in canine serum and prostatic tissue. J. Chromatogr. 493:1989;337-346.
30. Vancutsem P.M., Babish J.G. In vitro and in vivo study of the effects of enrofloxacin on hepatic cytochrome P450. Potential for drug interactions. Vet. Hum. Toxicol. 38:1996;254-259.