Fractions of aqueous and methanolic extracts from tomato (Solanum lycopersicum L.) present platelet antiaggregant activity

Blood Coagulation and Fibrinolysis

Volumn 23, Issue 2, 2012, Pages 109-117

  Fuentes, Eduado J ^a,b   Astudillo, Luis A ^a,b   Gutiérrez, Margarita I ^a,b   Contreras, Samuel O ^a   Bustamante, Luis O ^a   Rubio, Pia I ^a   Moore Carrasco, Rodrigo ^a,b   Alarcón, Marcelo A ^a,b   Fuentes, Jaime A ^a   González, Daniel E ^a   Palomo, Iván F ^a,b  

^a UNIVERSIDAD DE TALCA   (Chile)

^b Centro de Estudios en Alimentos Procesados (CEAP)   (Chile)

Author keywords

cardiovascular diseases; platelet antiaggregant activity; tomatoes

Indexed keywords

ANTITHROMBOCYTIC AGENT; PLANT EXTRACT; SOLANUM LYCOPERSICUM EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE AGGREGATION INHIBITION; TOMATO;

ANIMALS; CAROTENOIDS; CHROMATOGRAPHY, GEL; DRUG STABILITY; HUMANS; HYDROGEN-ION CONCENTRATION; LYCOPERSICON ESCULENTUM; PLANT EXTRACTS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RATS; RATS, WISTAR;

EID: 84856616324     PISSN: 09575235     EISSN: 14735733     Source Type: Journal    
DOI: 10.1097/MBC.0b013e32834d78dd     Document Type: Article

References (32)

1. World Health Organization. Informe sobre la salud en el mundo. Technical Report. Series ISBN 924356207X. WHO: Geneva, 2002.
2. Bustos P, Amigo H, Arteaga A, Acosta A, Rona R. Factores de riesgo de enfermedad cardiovascular en adultos jóvenes. Rev Méd Chile 2003; 131:973-980. (Pubitemid 40137751)
3. Mathers C, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006; 3:2011-2020.
4. Palomo I, Icaza G, Mujica V, Núñez L, Leiva E, Vásquez M, et al. Prevalencia de factores de riesgo cardiovascular clá sicos en población adulta de Talca, Chile, 2005. Rev Med Chile 2007; 135:904-912.
5. Badimon L, Vilahur G. Platelets, arterial thrombosis and cerebral ischemia. Cerebrovascular Diseases 2007; 24:30-39. (Pubitemid 350035851)
6. Estruch R, Martínez-González M, Corella D, Salas-Salvadó J, Ruiz-Gutié rrez V, Covas M, et al. Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Intern Med 2006; 145:1-11. (Pubitemid 46780599)
7. Pearson T, Blair S, Daniels S, Eckel R, Fair J, Fortmann S, et al. AHA guidelines for primary prevention of cardiovascular disease and stroke: 2002 update: consensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases. Circulation 2002; 106:388-391. (Pubitemid 34778969)
8. Palomo I, Leiva E, Vásquez M. Dieta mediterránea: prevención de las enfermedades cardiovasculares. Talca, Chile: Universidad de Talca Press, 2007.
9. Carlsen M, Halvorsen B, Holte K, Bohn S, Dragland S, Sampson L, et al. The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr J 2010; 9:1-11.
10. Palomo I, Fuentes E, Carrasco G, González D, Moore-Carrasco R. Actividad antioxidante, hipolipemiante y antiplaquetaria del tomate (Solanum lycopersicum L.), y el efecto de su procesamiento y almacenaje. Rev Chil Nutr 2010; 37:524-533.
11. Capanoglu E, Beekwilder J, Boyacioglu D, De Vos R, Hall R. The effect of industrial food processing on potentially health-beneficial tomato antioxidants. Crit Rev Food Sci Nutr 2010; 50:919-930.
12. Dutta-Roy A, Crosbie L, Gordon M. Effects of tomato extract on human platelet aggregation in vitro. Platelets 2001; 12:218-227. (Pubitemid 32578873)
13. O'Kennedy N, Crosbie L, Van Lieshout M, Broom J, Webb D, Duttaroy A. Effects of antiplatelet components of tomato extract on platelet function in vitro and ex vivo: a time-course cannulation study in healthy humans. Am J Clin Nutr 2006; 84:570-579. (Pubitemid 44713407)
14. O'Kennedy N, Crosbie L, Whelan S, Luther V, Horgan G, Broom J, et al. Effects of tomato extract on platelet function: a double-blinded crossover study in healthy humans. Am J Clin Nutr 2006; 84:561-569. (Pubitemid 44713406)
15. Lazarus S, Garg M. Tomato extract inhibits human platelet aggregation in vitro without increasing basal cAMP levels. Int J Food Sci Nutr 2004; 55:237-247.
16. Yamamoto J, Taka T, Yamada K, Ijiri Y, Murakami M, Hirata Y,et al. Tomatoes have natural antithrombotic effects. Br J Nutr 2003; 90:1031-1038. (Pubitemid 37548035)
17. Hostettmann K, Marston A, Hostettmann M. Preparative Chromatography techniques: applications in natural product isolation. Berlin: Springer; 1997.
18. Olives A, Cámara M, Sánchez M, Fernández V, López M. Application of a UV-vis detection-HPLC method for a rapid determination of lycopene and [beta]-carotene in vegetables. Food Chemistry 2006; 95:328-336.
19. Gadi D, Bnouham M, Aziz M, Ziyyat A, Legssyer A, Legrand C. Parsley extract inhibits in vitro and ex vivo platelet aggregation and prolongs bleeding time in rats. J Ethnopharmacol 2009; 125:170-174.
20. Akagi Y, Nio Y, Shimada S, Aoyama T. Influence of nonsteroidal anti-inflammatory drugs on the antiplatelet effects of aspirin in rats. Biol Pharm Bull 2011; 34:233-237.
21. Olfert E, Cross B, McWilliam A. Guide to the care and use of experimental animals. Ottawa: Canadian Council on Animal Care; 1993.
22. De C, Goossens J, Reneman R. Effects of anti-inflammatory, anticoagulant and vasoactive compounds on tail bleeding time, whole blood coagulation time and platelet retention by glass beads in rats. Thromb Res 1976; 8:179-193.
23. Born G, Cross M. The aggregation of blood platelets. J Physiol 1963; 168:178-195.
24. Torres-Urrutia C, Guzmán L, Schmeda-Hirschmann G, Moore-Carrasco R, Alarcón M, Astudillo L, et al. Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables. Blood Coagul Fibrinolysis 2011; 22:197-205.
25. Arazi HC, Doiny DG, Torcivia RS, Grancelli H, Waldman SV, Nojek C, et al. Impaired antiplatelet effect of aspirin, inflammation and platelet turnover in cardiac surgery. Interact Cardiovasc Thorac Surg 2010; 10:863-867.
26. Nguyen M, Schwart S. Lycopene: chemical and biological properties. Food Technol 1999; 53:38-45. (Pubitemid 129604898)
27. Shi J, Le Maguer M. Lycopene in tomatoes: chemical and physical properties affected by food processing. Crit Rev Biotechnol 2000; 20:293-334. (Pubitemid 32056133)
28. Agrawal H, Kaul N, Paradkar AR, Mahadik KR. Stability indicating HPTLC determination of clopidogrel bisulphate as bulk drug and in pharmaceutical dosage form. Talanta 2003; 61:581-589.
29. Devlin T. Bioquímica. Libro de texto con aplicaciones clínicas. Barcelona: Reverte; 2004.
30. Johnston-Cox HA, YangD,RavidK. Physiological implicationsofadenosine receptor-mediated platelet aggregation. J Cell Physiol 2011; 226:46-51.
31. Murphy K, Chronopoulos A, Singh I, Francis M, Moriarty H, Pike M, et al. Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function. Am J Clin Nutr 2003; 77:1466-1473. (Pubitemid 39655281)
32. Nuez F. El cultivo del tomate. Barcelona: Mundi-Prensa; 1995.