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Volumn 1, Issue , 2008, Pages 95-117

Bioinformatics Tools for Antibody Engineering

Author keywords

Bioinformatics; Biology; Conventions; Engineering; Resources

Indexed keywords


EID: 84856555072     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527619740.ch5     Document Type: Chapter
Times cited : (6)

References (64)
  • 1
    • 0031558798 scopus 로고    scopus 로고
    • Standard conformations for the canonical structures of immunoglobulins
    • Al-Lazikani, B., Lesk, A.M., Chothia, C. (1997) Standard conformations for the canonical structures of immunoglobulins. J Mol Biol 273: 927-948.
    • (1997) J Mol Biol , vol.273 , pp. 927-948
    • Al-Lazikani, B.1    Lesk, A.M.2    Chothia, C.3
  • 2
    • 0036171255 scopus 로고    scopus 로고
    • SACS-self-maintaining database of antibody crystal structure information
    • Allcorn, L.C., Martin, A.C.R. (2002) SACS-self-maintaining database of antibody crystal structure information. Bioinformatics 18: 175-181.
    • (2002) Bioinformatics , vol.18 , pp. 175-181
    • Allcorn, L.C.1    Martin, A.C.R.2
  • 3
    • 0031939497 scopus 로고    scopus 로고
    • Structural differences between the repertoires of mouse and human germline genes and their evolutionary implications
    • Almagro, J.C., Hernández, I., Ramírez, M. C., Vargas-Madrazo, E. (1998) Structural differences between the repertoires of mouse and human germline genes and their evolutionary implications. Immunogenetics 47: 355-363.
    • (1998) Immunogenetics , vol.47 , pp. 355-363
    • Almagro, J.C.1    Hernández, I.2    Ramírez, M.C.3    Vargas-Madrazo, E.4
  • 5
    • 0023976188 scopus 로고
    • Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus
    • Berman, J., Mellis, S., Pollock, R., Smith, C., Suh, H., Heinke, B., Kowal, C., Surti, U., Chess, L., Cantor, C., F.W., A. (1988) Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus. EMBO J, 7: 727-738.
    • (1988) EMBO J , vol.7 , pp. 727-738
    • Berman, J.1    Mellis, S.2    Pollock, R.3    Smith, C.4    Suh, H.5    Heinke, B.6    Kowal, C.7    Surti, U.8    Chess, L.9    Cantor, C.F.W.A.10
  • 7
    • 0021129784 scopus 로고
    • The immunoglobulin heavy chain variable region (IgH-V) locus in the mouse. I. One hundred IgH-V genes comprise seven families of homologous genes
    • Brodeur, P., Riblet, R. (1984) The immunoglobulin heavy chain variable region (IgH-V) locus in the mouse. I. One hundred IgH-V genes comprise seven families of homologous genes. Eur J Immunol 14: 922-930.
    • (1984) Eur J Immunol , vol.14 , pp. 922-930
    • Brodeur, P.1    Riblet, R.2
  • 8
    • 0023173201 scopus 로고
    • Prediction of the folding of short polypeptide segments by uniform conformational sampling
    • Bruccoleri, R.E., Karplus, M. (1987) Prediction of the folding of short polypeptide segments by uniform conformational sampling. Biopolymers, 26: 137-168.
    • (1987) Biopolymers , vol.26 , pp. 137-168
    • Bruccoleri, R.E.1    Karplus, M.2
  • 9
    • 0042511005 scopus 로고    scopus 로고
    • A graph-theory algorithm for rapid protein side-chain prediction
    • Canutescu, A.A., Shelenkov, A.A., Dunbrack, R.L. (2003) A graph-theory algorithm for rapid protein side-chain prediction. Protein Sci 12: 2001-2014.
    • (2003) Protein Sci , vol.12 , pp. 2001-2014
    • Canutescu, A.A.1    Shelenkov, A.A.2    Dunbrack, R.L.3
  • 10
    • 0023278330 scopus 로고
    • Canonical structures for the hypervariable regions of immunoglobulins
    • Chothia, C., Lesk, A.M. (1987) Canonical structures for the hypervariable regions of immunoglobulins. J Mol Biol 196: 901-917.
    • (1987) J Mol Biol , vol.196 , pp. 901-917
    • Chothia, C.1    Lesk, A.M.2
  • 12
    • 0028986982 scopus 로고
    • The human immunoglobulin VH repertoire
    • Cook, G., Tomlinson, I. (1995) The human immunoglobulin VH repertoire. Immun Today 16: 237-242.
    • (1995) Immun Today , vol.16 , pp. 237-242
    • Cook, G.1    Tomlinson, I.2
  • 14
    • 4143080377 scopus 로고    scopus 로고
    • VH gene segments in the mouse and human genome
    • de Bono, B., Madera, M., Chothia, C. (2004) VH gene segments in the mouse and human genome. J Mol Biol 342: 131-143.
    • (2004) J Mol Biol , vol.342 , pp. 131-143
    • de Bono, B.1    Madera, M.2    Chothia, C.3
  • 15
    • 0029083989 scopus 로고
    • SUBIM: A program for analysing the Kabat database and determining the variability subgroup of a new immunoglobulin sequence
    • Déret, S., Maissiat, C., Aucouturier, P., Chomilier, J. (1995) SUBIM: A program for analysing the Kabat database and determining the variability subgroup of a new immunoglobulin sequence. Comput Appl Biosci 11: 435-439.
    • (1995) Comput Appl Biosci , vol.11 , pp. 435-439
    • Déret, S.1    Maissiat, C.2    Aucouturier, P.3    Chomilier, J.4
  • 16
    • 0025103796 scopus 로고
    • Characterization of new mouse v groups
    • D'Hoostelaere, L., Klinman, D. (1990) Characterization of new mouse v groups. J Immunol 145: 2706-2712.
    • (1990) J Immunol , vol.145 , pp. 2706-2712
    • D'Hoostelaere, L.1    Klinman, D.2
  • 17
    • 0345641209 scopus 로고
    • A new classification of mouse VH sequences
    • Dildrop, R. (1984) A new classification of mouse VH sequences. Immunol Today 5: 85-86.
    • (1984) Immunol Today , vol.5 , pp. 85-86
    • Dildrop, R.1
  • 18
    • 0022272091 scopus 로고
    • VH-gene expression in murine lipopolysaccharide blasts distributes over the nine known VH-gene groups and may be random
    • Dildrop, R., Krawinkel, U., Winter, E., Rajewsky, K. (1985) VH-gene expression in murine lipopolysaccharide blasts distributes over the nine known VH-gene groups and may be random. Eur J Immunol 15: 1154-1156.
    • (1985) Eur J Immunol , vol.15 , pp. 1154-1156
    • Dildrop, R.1    Krawinkel, U.2    Winter, E.3    Rajewsky, K.4
  • 20
    • 0033493024 scopus 로고    scopus 로고
    • Ontology for immunogenetics: the IMGTONTOLOGY
    • Giudicelli, V., Lefranc, M.-P. (1999) Ontology for immunogenetics: the IMGTONTOLOGY. Bioinformatics 15: 1047-1054.
    • (1999) Bioinformatics , vol.15 , pp. 1047-1054
    • Giudicelli, V.1    Lefranc, M.-P.2
  • 21
    • 0035827172 scopus 로고    scopus 로고
    • Yet another numbering scheme for immunoglobulin variable domains: an automatic modeling and analysis tool
    • Honegger, A., Plückthun, A. (2001) Yet another numbering scheme for immunoglobulin variable domains: an automatic modeling and analysis tool. J Mol Biol 309: 657-670.
    • (2001) J Mol Biol , vol.309 , pp. 657-670
    • Honegger, A.1    Plückthun, A.2
  • 22
    • 0004208754 scopus 로고
    • Immunoglobulin Genes, 2nd edn
    • London: Academic Press, pp.
    • Honjo, T., Matsuda, F. (1995) Immunoglobulin Genes, 2nd edn. London: Academic Press, pp. 145-171.
    • (1995) , pp. 145-171
    • Honjo, T.1    Matsuda, F.2
  • 23
    • 0347755625 scopus 로고    scopus 로고
    • IMGT/3Dstructure-DB and IMGT/StructuralQuery, a database and a tool for immunoglobulin, T cell receptor and MHC structural data
    • Kaas, Q., Ruiz, M., Lefranc, M.-P. (2004) IMGT/3Dstructure-DB and IMGT/StructuralQuery, a database and a tool for immunoglobulin, T cell receptor and MHC structural data. Nucleic Acids Res 32: D208-D210.
    • (2004) Nucleic Acids Res , vol.32
    • Kaas, Q.1    Ruiz, M.2    Lefranc, M.-P.3
  • 24
    • 0004032583 scopus 로고
    • Sequences of Proteins of Immunological Interest
    • 5th edn. Bethesda, MD: US Department of Health and Human Services, National Institutes for Health
    • Kabat, E.A., Wu, T.T., Perry, H.M., Gottesman, K.S., Foeller, C. (1991). Sequences of Proteins of Immunological Interest, 5th edn. Bethesda, MD: US Department of Health and Human Services, National Institutes for Health.
    • (1991)
    • Kabat, E.A.1    Wu, T.T.2    Perry, H.M.3    Gottesman, K.S.4    Foeller, C.5
  • 25
    • 0022450491 scopus 로고
    • Organization and evolution of variable region genes of the human immunoglobulin heavy chain
    • Kodaira, M., Kinashi, T., Umemura, I., Matsuda, F., Noma, T., Ono, Y., Honjo, T. (1986) Organization and evolution of variable region genes of the human immunoglobulin heavy chain. J Mol Biol 190: 529-541.
    • (1986) J Mol Biol , vol.190 , pp. 529-541
    • Kodaira, M.1    Kinashi, T.2    Umemura, I.3    Matsuda, F.4    Noma, T.5    Ono, Y.6    Honjo, T.7
  • 26
    • 0025987995 scopus 로고
    • A new Igk-V family in the mouse
    • Kofler, R., Helmberg, A. (1991) A new Igk-V family in the mouse. Immunogenetics 34: 139-140.
    • (1991) Immunogenetics , vol.34 , pp. 139-140
    • Kofler, R.1    Helmberg, A.2
  • 27
    • 0026026248 scopus 로고
    • Evolutionary relationship between human and mouse immunoglobulin kappa light chain variable region genes
    • Kroemer, G., Helmberg, A., Bernot, A., Auffray, C., Kofler, R. (1991) Evolutionary relationship between human and mouse immunoglobulin kappa light chain variable region genes. Immunogenetics 33: 42-49.
    • (1991) Immunogenetics , vol.33 , pp. 42-49
    • Kroemer, G.1    Helmberg, A.2    Bernot, A.3    Auffray, C.4    Kofler, R.5
  • 28
    • 0023268717 scopus 로고
    • A novel family of variable region genes of the human immunoglobulin heavy chain
    • Lee, K., Matsuda, F., Kinashi, T., Kodaira, M., Honjo, T. (1987) A novel family of variable region genes of the human immunoglobulin heavy chain. J Mol Biol 195: 761-768.
    • (1987) J Mol Biol , vol.195 , pp. 761-768
    • Lee, K.1    Matsuda, F.2    Kinashi, T.3    Kodaira, M.4    Honjo, T.5
  • 29
    • 0343307090 scopus 로고    scopus 로고
    • Unique database numbering system for immunogenetic analysis
    • Lefranc, M.P. (1997) Unique database numbering system for immunogenetic analysis. Immunol Today 18: 509-509.
    • (1997) Immunol Today , vol.18 , pp. 509-509
    • Lefranc, M.P.1
  • 30
    • 0035166917 scopus 로고    scopus 로고
    • Imgt, the international immunogenetics database
    • Lefranc, M.-P. (2001) Imgt, the international immunogenetics database. Nucleic Acids Res 29: 207-209.
    • (2001) Nucleic Acids Res , vol.29 , pp. 207-209
    • Lefranc, M.-P.1
  • 31
    • 0030580057 scopus 로고    scopus 로고
    • Antibody-antigen interactions: Contact analysis and binding site topography
    • MacCallum, R.M., Martin, A.C., Thornton, J.M. (1996) Antibody-antigen interactions: Contact analysis and binding site topography. J Mol Biol 262: 732-745.
    • (1996) J Mol Biol , vol.262 , pp. 732-745
    • MacCallum, R.M.1    Martin, A.C.2    Thornton, J.M.3
  • 32
    • 0030030180 scopus 로고    scopus 로고
    • Deletional mapping of fifteen mouse VH gene families reveals a common organization for three Igh haplotypes
    • Mainville, C., Sheehan, K., Klaman, L., Giorgetti, C., Press, J., Brodeur, P. (1996) Deletional mapping of fifteen mouse VH gene families reveals a common organization for three Igh haplotypes. J Immunol 156: 1038-1046.
    • (1996) J Immunol , vol.156 , pp. 1038-1046
    • Mainville, C.1    Sheehan, K.2    Klaman, L.3    Giorgetti, C.4    Press, J.5    Brodeur, P.6
  • 34
    • 0023068367 scopus 로고
    • The structural basis of antigen-antibody recognition
    • Annu Rev Biophys Bioeng
    • Mariuzza, R.A., Phillips, S.E.V., Poljak, R.J. (1987) The structural basis of antigen-antibody recognition. Annu Rev Biophys Bioeng 139-159.
    • (1987) , pp. 139-159
    • Mariuzza, R.A.1    Phillips, S.E.V.2    Poljak, R.J.3
  • 35
    • 0029993902 scopus 로고    scopus 로고
    • Accessing the Kabat antibody sequence database by computer
    • Martin, A.C.R. (1996) Accessing the Kabat antibody sequence database by computer. Proteins Struct Funct Genet 25: 130-133.
    • (1996) Proteins Struct Funct Genet , vol.25 , pp. 130-133
    • Martin, A.C.R.1
  • 36
    • 0030589039 scopus 로고    scopus 로고
    • Structural families in homologous proteins: automatic classification, modelling and application to antibodies
    • Martin, A.C.R., Thornton, J.M. (1996) Structural families in homologous proteins: automatic classification, modelling and application to antibodies. J Mol Biol 263: 800-815.
    • (1996) J Mol Biol , vol.263 , pp. 800-815
    • Martin, A.C.R.1    Thornton, J.M.2
  • 37
    • 0024310232 scopus 로고
    • Modelling antibody hypervariable loops: A combined algorithm
    • Martin, A.C.R., Cheetham, J.C., Rees, A.R. (1989) Modelling antibody hypervariable loops: A combined algorithm. Proc Natl Acad Sci USA 86: 9268-9272.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 9268-9272
    • Martin, A.C.R.1    Cheetham, J.C.2    Rees, A.R.3
  • 38
    • 0032536197 scopus 로고    scopus 로고
    • Conformations of the third hypervariable region in the VH domain of immunoglobulins
    • Morea, V., Tramontano, A., Rustici, M., Chothia, C., Lesk, A.M. (1998) Conformations of the third hypervariable region in the VH domain of immunoglobulins. J Mol Biol 275: 269-294.
    • (1998) J Mol Biol , vol.275 , pp. 269-294
    • Morea, V.1    Tramontano, A.2    Rustici, M.3    Chothia, C.4    Lesk, A.M.5
  • 39
    • 0032568959 scopus 로고    scopus 로고
    • Automated classification of antibody complementarity determining region 3 of the heavy chain (H3) loops into canonical forms and its application to protein structure prediction
    • Oliva, B., Bates, P.A., Querol, E., Avilés, F. X., Sternberg, M.J. (1998) Automated classification of antibody complementarity determining region 3 of the heavy chain (H3) loops into canonical forms and its application to protein structure prediction. J Mol Biol 279: 1193-1210.
    • (1998) J Mol Biol , vol.279 , pp. 1193-1210
    • Oliva, B.1    Bates, P.A.2    Querol, E.3    Avilés, F.X.4    Sternberg, M.J.5
  • 41
    • 0028289241 scopus 로고
    • Anatomy of the antibody molecule
    • Padlan, Eduardo, A. (1994) Anatomy of the antibody molecule. Mol Immunol 31: 169-217.
    • (1994) Mol Immunol , vol.31 , pp. 169-217
    • Padlan, E.A.1
  • 42
    • 0017614064 scopus 로고
    • The structural basis for the specificity of antibody-antigen reactions and structural mechanisms for the diversification of antigen-binding specificities
    • Padlan, E.A. (1977) The structural basis for the specificity of antibody-antigen reactions and structural mechanisms for the diversification of antigen-binding specificities. Quant Rev Biophys 10: 35-65.
    • (1977) Quant Rev Biophys , vol.10 , pp. 35-65
    • Padlan, E.A.1
  • 43
    • 0021724851 scopus 로고
    • Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type
    • Pech, M., Jaenichen, H., Pohlenz, H., Neumaier, P., Klobeck, H., Zachau, H. (1984) Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type. J Mol Biol 176: 189-204.
    • (1984) J Mol Biol , vol.176 , pp. 189-204
    • Pech, M.1    Jaenichen, H.2    Pohlenz, H.3    Neumaier, P.4    Klobeck, H.5    Zachau, H.6
  • 44
    • 0015733869 scopus 로고
    • The three-dimensional structure of the Fab fragment of a human immunoglobulin at 2.8Å resolution
    • Poljak, R.J., Amzel, L.M., Avey, H.P., Chen, B.L., Phizackerley, R.P., Saul, F. (1973) The three-dimensional structure of the Fab fragment of a human immunoglobulin at 2.8Å resolution. Proc Natl Acad Sci USA 70: 3305-3310.
    • (1973) Proc Natl Acad Sci USA , vol.70 , pp. 3305-3310
    • Poljak, R.J.1    Amzel, L.M.2    Avey, H.P.3    Chen, B.L.4    Phizackerley, R.P.5    Saul, F.6
  • 45
    • 70449276523 scopus 로고
    • The hydrolysis of rabbit-globulin and antibodies with crystalline papain
    • Porter, R.R. (1959) The hydrolysis of rabbit-globulin and antibodies with crystalline papain. Biochem J 73: 119-127.
    • (1959) Biochem J , vol.73 , pp. 119-127
    • Porter, R.R.1
  • 46
    • 0035827837 scopus 로고    scopus 로고
    • VIR.II: a new interface with the antibody sequences in the Kabat database
    • Ramirez-Benitez, M.d.C., Moreno-Hagelsieb, G., Almagro, J.C. (2001) VIR.II: a new interface with the antibody sequences in the Kabat database. Biosystems, 61: 125-131.
    • (2001) Biosystems , vol.61 , pp. 125-131
    • Ramirez-Benitez, M.D.C.1    Moreno-Hagelsieb, G.2    Almagro, J.C.3
  • 48
    • 0020658557 scopus 로고
    • Evolutionary aspects of immunoglobulin heavy chain variable region (VH) gene subgroups
    • Rechavi, G., Ram, D., Glazer, L., Zakut, R., Givol, D. (1983) Evolutionary aspects of immunoglobulin heavy chain variable region (VH) gene subgroups. Proc Natl Acad Sci USA 90: 855-859.
    • (1983) Proc Natl Acad Sci USA , vol.90 , pp. 855-859
    • Rechavi, G.1    Ram, D.2    Glazer, L.3    Zakut, R.4    Givol, D.5
  • 49
    • 0025198397 scopus 로고
    • Structure and evolution of mammalian VH families
    • Schroeder, H.J., Hillson, J., Perlmutter, R. (1990) Structure and evolution of mammalian VH families. Int Immunol 2: 41-50.
    • (1990) Int Immunol , vol.2 , pp. 41-50
    • Schroeder, H.J.1    Hillson, J.2    Perlmutter, R.3
  • 50
    • 0001940078 scopus 로고
    • Antibody structure and function
    • In: Borreback, C. A.K. (ed.) Antibody Engineering. Oxford: Oxford University Press, pp.
    • Searle, S.J., Pedersen, J.T., Henry, A.H., Webster, D.M., Rees, A.R. (1994) Antibody structure and function. In: Borreback, C. A.K. (ed.) Antibody Engineering. Oxford: Oxford University Press, pp. 3-51.
    • (1994) , pp. 3-51
    • Searle, S.J.1    Pedersen, J.T.2    Henry, A.H.3    Webster, D.M.4    Rees, A.R.5
  • 51
    • 0023594991 scopus 로고
    • Human heavy-chain variable region gene family nonrandomly rearranged in familial chronic lymphocytic leukemia
    • Shen, A., Humphries, C., Tucker, P., Blattner, F. (1987) Human heavy-chain variable region gene family nonrandomly rearranged in familial chronic lymphocytic leukemia. Proc Natl Acad Sci USA 84: 8563-8567.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 8563-8567
    • Shen, A.1    Humphries, C.2    Tucker, P.3    Blattner, F.4
  • 52
    • 0030577371 scopus 로고    scopus 로고
    • Structural classification of CDR-H3 in antibodies
    • Shirai, H., Kidera, A., Nakamura, H. (1996) Structural classification of CDR-H3 in antibodies. FEBS Lett 399: 1-8.
    • (1996) FEBS Lett , vol.399 , pp. 1-8
    • Shirai, H.1    Kidera, A.2    Nakamura, H.3
  • 53
    • 0031963782 scopus 로고    scopus 로고
    • Evolution of immunoglobulin kappa chain variable region genes in vertebrates
    • Sitnikova, T., Nei, M. (1998) Evolution of immunoglobulin kappa chain variable region genes in vertebrates. Mol Biol Evol 15: 50-60.
    • (1998) Mol Biol Evol , vol.15 , pp. 50-60
    • Sitnikova, T.1    Nei, M.2
  • 54
    • 0031843744 scopus 로고    scopus 로고
    • Coevolution of immunoglobulin heavy-and light-chain variable-region gene families
    • Sitnikova, T., Su, C. (1998) Coevolution of immunoglobulin heavy-and light-chain variable-region gene families. Mol Biol Evol 15: 617-625.
    • (1998) Mol Biol Evol , vol.15 , pp. 617-625
    • Sitnikova, T.1    Su, C.2
  • 55
    • 0024472122 scopus 로고
    • Mouse Vκ gene classification by nucleic acid sequence similarity
    • Strohal, R., Helmberg, A., Kroemer, G., Kofler, R. (1989) Mouse Vκ gene classification by nucleic acid sequence similarity. Immunogenetics 30: 475-493.
    • (1989) Immunogenetics , vol.30 , pp. 475-493
    • Strohal, R.1    Helmberg, A.2    Kroemer, G.3    Kofler, R.4
  • 56
    • 0026785856 scopus 로고
    • The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops
    • Tomlinson, I. M., Walter, G., Marks, J. D., Llewelyn, M. B., Winter, G. (1992) The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J Mol Biol 227: 776-798.
    • (1992) J Mol Biol , vol.227 , pp. 776-798
    • Tomlinson, I.M.1    Walter, G.2    Marks, J.D.3    Llewelyn, M.B.4    Winter, G.5
  • 57
    • 0035178383 scopus 로고    scopus 로고
    • Protein-protein interfaces: Analysis of amino acid conservation in homodimers
    • Valdar, W.S., Thornton, J.M. (2001) Protein-protein interfaces: Analysis of amino acid conservation in homodimers. Proteins Struct Funct Genet 42: 108-124.
    • (2001) Proteins Struct Funct Genet , vol.42 , pp. 108-124
    • Valdar, W.S.1    Thornton, J.M.2
  • 59
    • 0014202658 scopus 로고
    • Electron microscopy of an antibody-hapten complex
    • Valentine, R.C., Green, N.M. (1967) Electron microscopy of an antibody-hapten complex. J Mol Biol 27: 615-617.
    • (1967) J Mol Biol , vol.27 , pp. 615-617
    • Valentine, R.C.1    Green, N.M.2
  • 60
    • 0034458999 scopus 로고    scopus 로고
    • WAM: an improved algorithm for modelling antibodies on the WEB
    • Whitelegg, N.R., Rees, A.R. (2000) WAM: an improved algorithm for modelling antibodies on the WEB. Protein Eng 13: 819-824.
    • (2000) Protein Eng , vol.13 , pp. 819-824
    • Whitelegg, N.R.1    Rees, A.R.2
  • 61
    • 1642330831 scopus 로고    scopus 로고
    • Antibody variable regions: Toward a unified modeling method
    • Whitelegg, N., Rees, A.R. (2004) Antibody variable regions: Toward a unified modeling method. Methods Mol Biol 248: 51-91.
    • (2004) Methods Mol Biol , vol.248 , pp. 51-91
    • Whitelegg, N.1    Rees, A.R.2
  • 64
    • 0014828908 scopus 로고
    • An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity
    • Wu, T.T., Kabat, E.A. (1970) An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity. J Exp Med 132: 211-250.
    • (1970) J Exp Med , vol.132 , pp. 211-250
    • Wu, T.T.1    Kabat, E.A.2


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