메뉴 건너뛰기




Volumn 7, Issue 6, 2011, Pages 892-901

Long-term cultured human neural stem cells undergo spontaneous transformation to tumor-initiating cells

Author keywords

Epidermal growth factor receptor (EGFR); Malignant transformation; Tumorigenesis; Xenograft

Indexed keywords

MUS; MUS MUSCULUS;

EID: 79961011472     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.7.892     Document Type: Article
Times cited : (38)

References (40)
  • 1
    • 0025190642 scopus 로고
    • CNS stem cells express a new class of intermediate filament protein
    • Lendahl U, Zimmerman LB, McKay RD. CNS stem cells express a new class of intermediate filament protein. Cell 1990; 60: 585-595.
    • (1990) Cell , vol.60 , pp. 585-595
    • Lendahl, U.1    Zimmerman, L.B.2    McKay, R.D.3
  • 3
    • 67650505037 scopus 로고    scopus 로고
    • Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation
    • Røsland GV, Svendsen A, Torsvik A, et al. Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Res. 2009; 69: 5331-5339.
    • (2009) Cancer Res , vol.69 , pp. 5331-5339
    • Røsland, G.V.1    Svendsen, A.2    Torsvik, A.3
  • 4
    • 84887212382 scopus 로고    scopus 로고
    • Tumorigenic potential of olfactory bulb-derived human adult neural stem cells associates with activation of TERT and NOTCH1
    • Casalbore P, Budoni M, Ricci-Vitiani L, et al. Tumorigenic potential of olfactory bulb-derived human adult neural stem cells associates with activation of TERT and NOTCH1. PLoS One. 2009; 4: e4434.
    • (2009) PLoS One , vol.e4434 , pp. 4
    • Casalbore, P.1    Budoni, M.2    Ricci-Vitiani, L.3
  • 5
    • 77749344571 scopus 로고    scopus 로고
    • In vivo transformation of neural stem cells following transplantation in the injured nervous system
    • Radtke C, Redeker J, Jokuszies A, et al. In vivo transformation of neural stem cells following transplantation in the injured nervous system. J Reconstr Microsurg. 2010; 26: 211-212.
    • (2010) J Reconstr Microsurg , vol.26 , pp. 211-212
    • Radtke, C.1    Redeker, J.2    Jokuszies, A.3
  • 6
    • 66949152828 scopus 로고    scopus 로고
    • Spontaneous in vitro transformation of adult neural precursors into stem-like cancer cells
    • Siebzehnrubl FA, Jeske I, Müller D, et al. Spontaneous in vitro transformation of adult neural precursors into stem-like cancer cells. Brain Pathol. 2009; 19: 399-408.
    • (2009) Brain Pathol , vol.19 , pp. 399-408
    • Siebzehnrubl, F.A.1    Jeske, I.2    Müller, D.3
  • 7
    • 34249828947 scopus 로고    scopus 로고
    • Targeting sensory axon regeneration in adult spinal cord
    • Tang XQ, Heron P, Mashburn C, et al. Targeting sensory axon regeneration in adult spinal cord. J Neurosci. 2007; 27: 6068-6078.
    • (2007) J Neurosci , vol.27 , pp. 6068-6078
    • Tang, X.Q.1    Heron, P.2    Mashburn, C.3
  • 8
    • 61449171881 scopus 로고    scopus 로고
    • Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient
    • Amariglio N, Hirshberg A, Scheithauer BW, et al. Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Med. 2009; 6: e1000029.
    • (2009) PLoS Med , vol.e1000029 , pp. 6
    • Amariglio, N.1    Hirshberg, A.2    Scheithauer, B.W.3
  • 9
  • 10
    • 0344735881 scopus 로고    scopus 로고
    • Cancerous stem cells can arise from pediatric brain tumors
    • Hemmati HD, Nakano I, Lazareff JA, et al. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A 2003; 100: 15178-15183.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15178-15183
    • Hemmati, H.D.1    Nakano, I.2    Lazareff, J.A.3
  • 11
    • 35949002429 scopus 로고    scopus 로고
    • Malignant astrocytic glioma: Genetics, biology, and paths to treatment
    • Furnari FB, Fenton T, Bachoo RM, et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev 2007; 21: 2683-2710.
    • (2007) Genes Dev , vol.21 , pp. 2683-2710
    • Furnari, F.B.1    Fenton, T.2    Bachoo, R.M.3
  • 12
    • 9944228133 scopus 로고    scopus 로고
    • Isolation and characterization of neural stem cells from human fetal striatum
    • Li X, Xu J, Bai Y, et al. Isolation and characterization of neural stem cells from human fetal striatum. Biochem Biophys Res Commun 2005; 326: 425-434.
    • (2005) Biochem Biophys Res Commun , vol.326 , pp. 425-434
    • Li, X.1    Xu, J.2    Bai, Y.3
  • 14
    • 0034595855 scopus 로고    scopus 로고
    • Generalized potential of adult neural stem cells
    • Clarke DL, Johansson CB, Wilbertz J, et al. Generalized potential of adult neural stem cells. Science 2000; 288: 1660-1663.
    • (2000) Science , vol.288 , pp. 1660-1663
    • Clarke, D.L.1    Johansson, C.B.2    Wilbertz, J.3
  • 15
    • 0034032642 scopus 로고    scopus 로고
    • Cell replacement therapies for central nervous system disorders
    • Bjorklund A, Lindvall O. Cell replacement therapies for central nervous system disorders. Nat Neurosci 2000; 3: 537-544.
    • (2000) Nat Neurosci , vol.3 , pp. 537-544
    • Bjorklund, A.1    Lindvall, O.2
  • 16
    • 0034718896 scopus 로고    scopus 로고
    • Regenerating the damaged central nervous system
    • Horner PJ, Gage FH. Regenerating the damaged central nervous system. Nature 2000; 407: 963-970.
    • (2000) Nature , vol.407 , pp. 963-970
    • Horner, P.J.1    Gage, F.H.2
  • 17
    • 37749016965 scopus 로고    scopus 로고
    • Cancer stem cells with genetic instability: The best vehicle with the best engine for cancer
    • Lagasse E. Cancer stem cells with genetic instability: the best vehicle with the best engine for cancer. Gene Ther. 2008; 15: 136-142.
    • (2008) Gene Ther , vol.15 , pp. 136-142
    • Lagasse, E.1
  • 18
    • 4143071470 scopus 로고    scopus 로고
    • Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex
    • Kelly S, Bliss TM, Shah AK, et al. Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex. Proc Natl Acad Sci U S A 2004; 101: 11839-11844.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 11839-11844
    • Kelly, S.1    Bliss, T.M.2    Shah, A.K.3
  • 19
    • 70350215773 scopus 로고    scopus 로고
    • Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpression
    • Micallef J, Taccone M, Mukherjee J, et al. Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpression. Cancer Res 2009; 69: 7548-7556.
    • (2009) Cancer Res , vol.69 , pp. 7548-7556
    • Micallef, J.1    Taccone, M.2    Mukherjee, J.3
  • 20
    • 0034987702 scopus 로고    scopus 로고
    • Malignant glioma: Genetics and biology of a grave matter
    • Maher EA, Furnari FB, Bachoo RM, et al. Malignant glioma: genetics and biology of a grave matter. Genes Dev 2001; 15: 1311-1333.
    • (2001) Genes Dev , vol.15 , pp. 1311-1333
    • Maher, E.A.1    Furnari, F.B.2    Bachoo, R.M.3
  • 21
    • 33846029123 scopus 로고    scopus 로고
    • A perivascular niche for brain tumor stem cells
    • Calabrese C, Poppleton H, Kocak M, et al. A perivascular niche for brain tumor stem cells. Cancer Cell 2007; 11: 69-82.
    • (2007) Cancer Cell , vol.11 , pp. 69-82
    • Calabrese, C.1    Poppleton, H.2    Kocak, M.3
  • 22
    • 34648821254 scopus 로고    scopus 로고
    • Making a tumour's bed: Glioblastoma stem cells and the vascular niche
    • Gilbertson RJ, Rich JN. Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat Rev Cancer 2007; 7: 733-736.
    • (2007) Nat Rev Cancer , vol.7 , pp. 733-736
    • Gilbertson, R.J.1    Rich, J.N.2
  • 23
    • 19944426191 scopus 로고    scopus 로고
    • Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway
    • Imitola J, Raddassi K, Park KI, et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A 2004; 101: 18117-18122.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 18117-18122
    • Imitola, J.1    Raddassi, K.2    Park, K.I.3
  • 24
    • 51849108509 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF)-1{alpha} directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)
    • Han Z, Ren H, Zhao H, et al. Hypoxia-inducible factor (HIF)-1{alpha} directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF). Carcinogenesis 2008; 29: 1853-1861.
    • (2008) Carcinogenesis , vol.29 , pp. 1853-1861
    • Han, Z.1    Ren, H.2    Zhao, H.3
  • 25
    • 33645772227 scopus 로고    scopus 로고
    • Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain
    • Sun L, Hui A, Su Q, et al. Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell 2006; 9: 287-300.
    • (2006) Cancer Cell , vol.9 , pp. 287-300
    • Sun, L.1    Hui, A.2    Su, Q.3
  • 26
    • 0032508033 scopus 로고    scopus 로고
    • The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
    • Tachibana K, Hirota S, Iizasa H, et al. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 1998; 393: 591-594.
    • (1998) Nature , vol.393 , pp. 591-594
    • Tachibana, K.1    Hirota, S.2    Iizasa, H.3
  • 27
    • 77950201880 scopus 로고    scopus 로고
    • Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis
    • Liu Y, Ji R, Li J, et al. Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis. J Exp Clin Cancer Res 2010; 29: 16.
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 16
    • Liu, Y.1    Ji, R.2    Li, J.3
  • 28
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000; 103: 211-225.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 29
    • 33344464945 scopus 로고    scopus 로고
    • CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment
    • Burger JA, Kipps TJ: CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 2006; 107: 1761-1767.
    • (2006) Blood , vol.107 , pp. 1761-1767
    • Burger, J.A.1    Kipps, T.J.2
  • 30
    • 67651166789 scopus 로고    scopus 로고
    • CXCR4 and matrix metalloproteinase-1 are elevated in breast carcinoma-associated fibroblasts and in normal mammary fibroblasts exposed to factors secreted by breast cancer cells
    • Eck SM, Cote AL, Winkelman WD, et al. CXCR4 and matrix metalloproteinase-1 are elevated in breast carcinoma-associated fibroblasts and in normal mammary fibroblasts exposed to factors secreted by breast cancer cells. Mol Cancer Res 2009; 7: 1033-1044.
    • (2009) Mol Cancer Res , vol.7 , pp. 1033-1044
    • Eck, S.M.1    Cote, A.L.2    Winkelman, W.D.3
  • 31
    • 15044365682 scopus 로고    scopus 로고
    • CXCR4 activation induces epidermal growth factor receptor transactivation in an ovarian cancer cell line
    • Porcile C, Bajetto A, Barbero S, et al. CXCR4 activation induces epidermal growth factor receptor transactivation in an ovarian cancer cell line. Ann N Y Acad Sci 2004; 1030: 162-169.
    • (2004) Ann N Y Acad Sci , vol.1030 , pp. 162-169
    • Porcile, C.1    Bajetto, A.2    Barbero, S.3
  • 32
    • 47249141913 scopus 로고    scopus 로고
    • Enhanced expression of the CXCl12/SDF-1 chemokine receptor CXCR7 after cerebral ischemia in the rat brain
    • Schonemeier B, Schulz S, Hoellt V, et al. Enhanced expression of the CXCl12/SDF-1 chemokine receptor CXCR7 after cerebral ischemia in the rat brain. J Neuroimmunol 2008; 198: 39-45.
    • (2008) J Neuroimmunol , vol.198 , pp. 39-45
    • Schonemeier, B.1    Schulz, S.2    Hoellt, V.3
  • 34
    • 0034629335 scopus 로고    scopus 로고
    • Chemokine receptors CXCR-1/2 activate mitogen-activated protein kinase via the epidermal growth factor receptor in ovarian cancer cells
    • Venkatakrishnan G, Salgia R, Groopman JE. Chemokine receptors CXCR-1/2 activate mitogen-activated protein kinase via the epidermal growth factor receptor in ovarian cancer cells. J Biol Chem 2000; 275: 6868-6875.
    • (2000) J Biol Chem , vol.275 , pp. 6868-6875
    • Venkatakrishnan, G.1    Salgia, R.2    Groopman, J.E.3
  • 35
    • 34547730932 scopus 로고    scopus 로고
    • EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes
    • Grandal MV, Zandi R, Pedersen MW, et al. EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes. Carcinogenesis 2007; 28: 1408-1417.
    • (2007) Carcinogenesis , vol.28 , pp. 1408-1417
    • Grandal, M.V.1    Zandi, R.2    Pedersen, M.W.3
  • 36
    • 4644238311 scopus 로고    scopus 로고
    • EGFR mutations and sensitivity to gefitinib
    • Rossi G, Marchioni A, Longo L. EGFR mutations and sensitivity to gefitinib. N Engl J Med 2004; 351: 1260-1261.
    • (2004) N Engl J Med , vol.351 , pp. 1260-1261
    • Rossi, G.1    Marchioni, A.2    Longo, L.3
  • 37
    • 33845926387 scopus 로고    scopus 로고
    • Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain
    • Lee JC, Vivanco I, Beroukhim R, et al. Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. PLoS Med 2006; 3: e485.
    • (2006) PLoS Med , vol.e485 , pp. 3
    • Lee, J.C.1    Vivanco, I.2    Beroukhim, R.3
  • 38
    • 0029146954 scopus 로고
    • EGFR gene ampli-fication--rearrangement in human glioblastomas
    • Schwechheimer K, Huang S, Cavenee WK. EGFR gene ampli-fication--rearrangement in human glioblastomas. Int J Cancer 1995; 62: 145-148.
    • (1995) Int J Cancer , vol.62 , pp. 145-148
    • Schwechheimer, K.1    Huang, S.2    Cavenee, W.K.3
  • 39
    • 70349456789 scopus 로고    scopus 로고
    • EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines
    • Bax DA, Gaspar N, Little SE, et al. EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines. Clin Cancer Res 2009; 15: 5753-5761.
    • (2009) Clin Cancer Res , vol.15 , pp. 5753-5761
    • Bax, D.A.1    Gaspar, N.2    Little, S.E.3
  • 40
    • 77955911497 scopus 로고    scopus 로고
    • Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cyto-kine circuit in glioblastoma
    • Inda MM, Bonavia R, Mukasa A, et al. Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cyto-kine circuit in glioblastoma. Genes Dev 2010; 24: 1731-1745.
    • (2010) Genes Dev , vol.24 , pp. 1731-1745
    • Inda, M.M.1    Bonavia, R.2    Mukasa, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.