Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: Role of fatty acid amide hydrolase

Journal of Psychopharmacology

Volumn 26, Issue 1, 2012, Pages 83-91

  Butler, Ryan K ^a   Ford, Gemma K ^a   Hogan, Michelle ^a   Roche, Michelle ^a   Doyle, Karen M ^a   Kelly, John P ^a   Kendall, David A ^b   Chapman, Victoria ^b   Finn, David P ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Akt (protein kinase B); endocannabinoids; fatty acid amide hydrolase (FAAH); fear; pain; periaqueductal grey (PAG); rats

Indexed keywords

ANANDAMIDE; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; FATTY ACID AMIDASE; PROTEIN KINASE B;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME INHIBITION; FEAR; IMMUNOBLOTTING; MALE; NOCICEPTIVE PAIN; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; TREATMENT RESPONSE;

AMIDOHYDROLASES; ANALGESIA; ANIMALS; ARACHIDONIC ACIDS; BEHAVIOR, ANIMAL; BENZAMIDES; CARBAMATES; CONDITIONING (PSYCHOLOGY); ENDOCANNABINOIDS; ETHANOLAMINES; EXPLORATORY BEHAVIOR; FEAR; FORMALDEHYDE; HIPPOCAMPUS; MALE; MOTOR ACTIVITY; NOCICEPTION; PAIN; PERIAQUEDUCTAL GRAY; POLYUNSATURATED ALKAMIDES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION;

EID: 84856501971     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881111413823     Document Type: Article

References (38)

1. Asmundson GJ, Katz J. Understanding the co-occurrence of anxiety disorders and chronic pain: state-of-the-art. Depress Anxiety. 2009 ; 26: 888-901
2. Butler RK, Finn DP. Stress-induced analgesia. Prog Neurobiol. 2009 ; 88: 184-202
3. Butler RK, Rea K, Lang Y, et al. Endocannabinoid-mediated enhancement of fear-conditioned analgesia in rats: Opioid receptor dependency and molecular correlates. Pain. 2008 ; 140: 491-500
4. Calcagnetti DJ, Helmstetter FJ, Fanselow MS. Quaternary naltrexone reveals the central mediation of conditional opioid analgesia. Pharmacol Biochem Behav. 1987 ; 27: 529-531 (Pubitemid 17107026)
5. Cannich A, Wotjak CT, Kamprath K, et al. CB1 cannabinoid receptors modulate kinase and phosphatase activity during extinction of conditioned fear in mice. Learn Mem. 2004 ; 11: 625-632 (Pubitemid 39299714)
6. Chhatwal JP, Ressler KJ. Modulation of fear and anxiety by the endogenous cannabinoid system. CNS Spectr. 2007 ; 12: 211-220 (Pubitemid 46555890)
7. Connell K, Bolton N, Olsen D, et al. Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia. Neurosci Lett. 2006 ; 397: 180-184
8. Dahlhoff V, Siegmund A, Golub Y, et al. AKT/GSK-3beta/beta-catenin signalling within hippocampus and amygdala reflects genetically determined differences in posttraumatic stress disorder like symptoms. Neuroscience. 2010 ; 169: 1216-1226
9. de Novellis V, Palazzo E, Rossi F, et al. The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats. Neuropharmacology. 2008 ; 55: 1105-1113
10. Finn DP. Endocannabinoid-mediated modulation of stress responses: physiological and pathophysiological significance. Immunobiology. 2010 ; 215: 629-646
11. Finn DP, Beckett SR, Richardson D, et al. Evidence for differential modulation of conditioned aversion and fear-conditioned analgesia by CB1 receptors. Eur J Neurosci. 2004 ; 20: 848-852 (Pubitemid 39036946)
12. Finn DP, Jhaveri MD, Beckett SR, et al. Behavioral, central monoaminergic and hypothalamo-pituitary-adrenal axis correlates of fear-conditioned analgesia in rats. Neuroscience. 2006 ; 138: 1309-1317 (Pubitemid 43363547)
13. Finn DP, Jhaveri MD, Beckett SR, et al. Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats. Neuropharmacology. 2003 ; 45: 594-604 (Pubitemid 36980816)
14. Ford GK, Finn DP. Clinical correlates of stress-induced analgesia: evidence from pharmacological studies. Pain. 2008 ; 140: 3-7
15. Forman-Hoffman VL, Peloso PM, Black DW, et al. Chronic widespread pain in veterans of the first Gulf War: impact of deployment status and associated health effects. J Pain. 2007 ; 8: 954-961 (Pubitemid 350161435)
16. Geuze E, Westenberg HG, Jochims A, et al. Altered pain processing in veterans with posttraumatic stress disorder. Arch Gen Psychiatry. 2007 ; 64: 76-85 (Pubitemid 46041741)
17. Gomez del Pulgar T, Velasco G, Guzman M. The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt. Biochem J. 2000 ; 347: 369-373 (Pubitemid 30229383)
18. Guindon J, Hohmann AG. The endocannabinoid system and pain. CNS Neurol Disord Drug Targets. 2009 ; 8: 403-421
19. Helmstetter FJ, Fanselow MS. Effects of naltrexone on learning and performance of conditional fear-induced freezing and opioid analgesia. Physiol Behav. 1987a ; 39: 501-505 (Pubitemid 17040550)
20. Helmstetter FJ, Fanselow MS. Strain differences in reversal of conditional analgesia by opioid antagonists. Behav Neurosci. 1987b ; 101: 735-737 (Pubitemid 18045114)
21. Hohmann AG, Suplita RL, Bolton NM, et al. An endocannabinoid mechanism for stress-induced analgesia. Nature. 2005 ; 435: 1108-1112 (Pubitemid 40910518)
22. Hohmann AG, Suplita RL. Endocannabinoid mechanisms of pain modulation. AAPS J. 2006 ; 8: E693-708
23. Jayamanne A, Greenwood R, Mitchell VA, et al. Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br J Pharmacol. 2006 ; 147: 281-288 (Pubitemid 43214685)
24. Kathuria S, Gaetani S, Fegley D, et al. Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med. 2003 ; 9: 76-81 (Pubitemid 36098263)
25. Maione S, Bisogno T, de Novellis V, et al. Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors. Pharmacol Exp Ther. 2006 ; 316: 969-982 (Pubitemid 43345268)
26. Marsicano G, Wotjak CT, Azad SC, et al. The endogenous cannabinoid system controls extinction of aversive memories. Nature. 2002 ; 418: 530-534 (Pubitemid 34851398)
27. Moreira FA, Aguiar DC, Campos AC, et al. Antiaversive effects of cannabinoids: is the periaqueductal gray involved?. Neural Plast. 2009 2009 ;: 625469
28. Palkovits M Guide and Map for the Isolated Removal of Individual Cell Groups from the Rat Brain. Budapest: Akadómiai Kiadœ 1980 :
29. Paxinos G, Watson C The Rat Brain in Stereotaxic Coordinates. New York: Academic Press ; 1998 :
30. Rea K, Roche M, Finn DP. Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate. Br J Pharmacol. 2007 ; 152: 633-648 (Pubitemid 350034981)
31. Resstel LB, Moreira FA, Guimaraes FS. Endocannabinoid system and fear conditioning. Vitam Horm. 2009 ; 81: 421-440
32. Roche M, Johnston P, Mhuircheartaigh ON, et al. Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear. Eur J Pain. 2010 ;: 487-495
33. Roche M, O'Connor E, Diskin C, et al. The effect of CB(1) receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats. Eur J Neurosci. 2007 ; 26: 2643-2653 (Pubitemid 350050435)
34. Sui L, Wang J, Li BM. Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex. Learn Mem. 2008 ; 15: 762-776
35. Sun RQ, Tu YJ, Yan JY, et al. Activation of protein kinase B/Akt signaling pathway contributes to mechanical hypersensitivity induced by capsaicin. Pain. 2006 ; 120: 86-96
36. Suplita RL, Farthing JN, Gutierrez T, et al. Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla. Neuropharmacology. 2005 ; 49: 1201-1209 (Pubitemid 41608644)
37. Terzian AL, Aguiar DC, Guimarães FS, et al. Modulation of anxiety-like behaviour by Transient Receptor Potential Vanilloid Type 1 (TRPV1) channels located in the dorsolateral periaqueductal gray. Eur Neuropsychopharmacol. 2009 ; 19: 188-195
38. Watson GS, Sufka KJ, Coderre TJ. Optimal scoring strategies and weights for the formalin test in rats. Pain. 1997 ; 70: 53-58 (Pubitemid 27128297)