Epidermal growth factor receptor (EGFR) and neuregulin (Neu) activation in human airway epithelial cells exposed to nickel acetate

Toxicology in Vitro

Volumn 26, Issue 2, 2012, Pages 280-287

  Giunta, S ^a   Castorina, A ^a   Scuderi, S ^a   Patti, C ^a   D'Agata, V ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

Airway epithelial cells; Apoptosis; Epidermal growth factor; Nickel

Indexed keywords

CELL DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; NEU DIFFERENTIATION FACTOR; NICKEL; NICKEL ACETATE; PROTEIN BAX; PROTEIN BCL 2; TYROSINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RESPIRATORY EPITHELIUM;

ACETATES; AIR POLLUTANTS, OCCUPATIONAL; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRONCHI; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; DNA DAMAGE; EPITHELIAL CELLS; HUMANS; NEUREGULINS; ORGANOMETALLIC COMPOUNDS; PROTO-ONCOGENE PROTEINS C-BCL-2; PULMONARY ALVEOLI; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER;

EID: 84856488470     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.12.012     Document Type: Article

References (40)

1. Ahamed M. Toxic response of nickel nanoparticles in human lung epithelial A549 cells. Toxicol. In Vitro. 2011, 25:930-936.
2. Baselga J., Arteaga C.L. Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J. Clin. Oncol. 2005, 23:2445-2459.
3. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
4. Cangul H., Broday L., Salnikow K., Sutherland J., Peng W., Zhang Q., Poltaratsky V., Yee H., Zoroddu M.A., Costa M. Molecular mechanisms of nickel carcinogenesis. Toxicol. Lett. 2002, 127:69-75.
5. Castorina A., Tiralongo A., Cavallo D., Loreto C., Carnazza M.L., Iavicoli S., D'Agata V. Expression profile of ErbB receptor's family in human alveolar type 2-like cell line A549 exposed to hexavalent chromium. Toxicol. In Vitro. 2008, 22:541-547.
6. Chen W., Martindale J.L., Holbrook N.J., Liu Y. Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc. Mol. Cell. Biol. 1998, 18:5178-5188.
7. Correa P., Mark J.S. Miller. Carcinogenesis, apoptosis and cell proliferation. Br. Med. Bull. 1998, 54:151-162.
8. Costa M. Molecular mechanisms of nickel carcinogenesis. Biol. Chem. 2002, 383:961-967.
9. Cruz M.T., Gonçalo M., Figueiredo A., Carvalho A.P., Duarte C.B., Lopes M.C. Contact sensitizer nickel sulfate activates the transcription factors NF-κB and AP-1 and increases the expression of nitric oxide synthase in a skin dendritic cell line. Exp. Dermatol. 2004, 13:18-26.
10. Denkhaus E., Salnikow K. Nickel essentiality, toxicity, and carcinogenicity. Crit. Rev. Oncol. Hematol. 2002, 42:35-36.
11. Ding J., Zhang X., Li J., Song L., Ouyang W., Zhang D., Xue C., Costa M., Meléndez J.A., Huang C. Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKKalpha- and p50-independent pathway. J. Biol. Chem. 2006, 281:39022-39032.
12. Forloni G., Angeretti N., Chiesa N., Monzoni E., Salmona M., Bugiani O., Tagliavini F. Neurotoxicity of a prion protein fragment. Nature 1993, 362:543-546.
13. Kasprzak K.S., Sunderman J.F.W., Salnikow K. Nickel carcinogenesis. Mutat. Res. 2003, 533:67-97.
14. Kawasaki S., Takizawa H., Takami K., Desaki M., Okazaki H., Kasama T., Kobayashi K., Yamamoto K., Nakahara K., Tanaka M., Sagai M., Ohtoshi T. Benzene-extracted components are important for the major activity of diesel exhaust particles-effect on interleukin-8 gene expression in human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 2001, 24:419-426.
15. Kim K., Lee S.H., Seo Y.R., Perkins S.N., Kasprzak K.S. Nickel(II)-induced apoptosis in murine T cell hybridoma cells is associated with increased fas ligand expression. Toxicol. Appl. Pharmacol. 2002, 185:41-47.
16. Kundu S., Sengupta S., Bhattacharyya A. EGFR upregulates inflammatory and proliferative responses in human lung adenocarcinoma cell line (A549), induced by lower dose of cadmium chloride. Inhal. Toxicol. 2011, 23:339-348.
17. Laan M., Bozinovski S., Anderson G. Cigarette smoke inhibits lipopolysaccharide-induced production of inflammatory cytokines by suppressing the activation of activator protein-1 in bronchial epithelial cells. J. Immunol. 2004, 173:4164-4170.
18. Lee Y.W., Klein C.B., Kargacin B., Salnikow K., Kitahara J., Dowjat K., Zhitkovich A., Christie N.T., Costa M. Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens. Mol. Cell. Biol. 1995, 15:2547-2557.
19. Li X., Lee J.W., Graves L.M., Earp H.S. Angiotensin II stimulates ERK via two pathways in epithelial cells: protein kinase C suppresses a G protein-coupled receptor-EGF receptor transactivation pathway. EMBO J. 1998, 17:2574-2583.
20. Liu Z.G., Lewis J., Wang T.H., Cook A. Role of c-Jun N-terminal kinase in apoptosis. Methods Cell Biol. 2001, 66:187-195.
21. Mollerup S., Rivedal E., Moehle L., Haugen A. Nickel(II) induces alterations in EGF- and TGF-beta 1-mediated growth control during malignant transformation of human kidney epithelial cells. Carcinogenesis 1996, 17:361-367.
22. Mosesson Y., Yarden Y. Oncogenic growth factor receptors: implications for signal transduction therapy. Semin Cancer Biol. 2004, 14:262-270.
23. Olayioye M.A., Neve R.M., Lane H.A., Hynes N.E. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J. 2000, 19:3159-3167.
24. Pan J., Chang Q., Wang X., Son Y., Zhang Z., Chen G., Luo J., Bi Y., Chen F., Shi X. Reactive oxygen species-activated Akt/ASK1/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells. Chem. Res. Toxicol. 2010, 23:568-577.
25. Pan J.J., Chang Q.S., Wang X., Son Y.O., Liu J., Zhang Z., Bi Y.Y., Shi X. Activation of Akt/GSK3β and Akt/Bcl-2 signaling pathways in nickel-transformed BEAS-2B cells. Int. J. Oncol. 2011, 39:1285-1294.
26. Pascale A., Fortino I., Covoni S., Trabucchi M., Wetsel W.C., Battaini F. Functional impairment in protein kinase C by RACK1 (receptor for activated C kinase 1) deficiency in aged rat brain cortex. J. Neurochem. 1996, 67:2471-2477.
27. Salnikow K., Gao M., Voitkun V., Huang X., Costa M. Altered oxidative stress responses in nickel-resistant mammalian cells. Cancer Res. 1994, 54:6407-6412.
28. Salnikow K., Costa M. Epigenetic mechanisms of nickel carcinogenesis J. Environ. Pathol. Toxicol. Oncol. 2000, 19:307-318.
29. Salnikow K., Davidson T., Zhang Q., Chen L.C., Su W., Costa M. The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis. Cancer Res. 2003, 63:3524-3530.
30. Schmittgen T.D., Livak K.J. Analyzing real-time PCR data by the comparative C(T) method. Nat. Protoc. 2008, 3:1101-1108.
31. Shiao Y.H., Lee S.H., Kasprzak K.S. Cell cycle arrest, apoptosis and p53 expression in nickel(II) acetate-treated Chinese hamster ovary cells. Carcinogenesis 1998, 19:1203-1207.
32. Sivulka D.J. Assessment of respiratory carcinogenicity associated with exposure to metallic nickel: a review. Regul. Toxicol. Pharmacol. 2005, 43:117-133.
33. Sonenberg N., Hinnebusch A.G. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 2009, 136:731-745.
34. Wilson M.R., Stone V., Cullen R.T., Searl A., Maynard R.L., Donaldson K. In vitro toxicology of respirable Montserrat volcanic ash. Occup. Environ. Med. 2000, 57:727-733.
35. Wu W., Graves L.M., Jaspers I., Devlin R.B., Reed W., Samet J.M. Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metals. Am. J. Physiol. 1999, 277:924-931.
36. Wyllie A.H., Bellamy C.O., Bubb V.J., Clarke A.R., Corbet S., Curtis L., Harrison D.J., Hooper M.L., Toft N., Webb S., Bird C.C. Apoptosis and carcinogenesis. Br. J. Cancer 1999, 1:34-37.
37. Yarden Y., Sliwkowski M.X. Untangling the ErbB signalling network. Nat. Rev. Mol. Cell Biol. 2001, 2:127-137.
38. Zandi R., Larsen A.B., Andersen P., Stockhausen M.T., Poulsen H.S. Mechanisms for oncogenic activation of the epidermal growth factor receptor. Cell Signal. 2007, 19:2013-2023.
39. Zhao J., Bowman L., Zhang X., Shi X., Jiang B., Castranova V., Ding M. Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway. J. Nanobiotechnol. 2009, 7:2.
40. Zwick E., Daub H., Aoki N., Yamaguchi-Aoki Y., Tinhofer I., Maly K., Ullrich A. Critical role of calcium-dependent epidermal growth factor receptor transactivation in PC12 cell membrane depolarization and bradykinin signaling. J. Biol. Chem. 1997, 272:24767-24770.