Nickel(II) induces alterations in EGF- and TGF-β1-mediated growth control during malignant transformation of human kidney epithelial cells

Carcinogenesis

Volumn 17, Issue 2, 1996, Pages 361-367

  Mollerup, Steen ^a   Rivedal, Edgar ^b   Mœhle, Lovise ^a   Haugen, Aage ^a  

^a NATIONAL INSTITUTE OF OCCUPATIONAL HEALTH   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; NICKEL; PHOSPHOPROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; GROWTH REGULATION; HUMAN; HUMAN CELL; KIDNEY EPITHELIUM; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR DENSITY;

CELL DIVISION; CELLS, CULTURED; DNA; EPIDERMAL GROWTH FACTOR; HUMANS; KIDNEY; NICKEL; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA;

EID: 0029937673     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.2.361     Document Type: Article

References (59)

1. Coogan, T.P., Latta, D.M., Snow, E.T. and Costa, M. (1989) Toxicity and carcinogenicity of nickel compounds. Crit. Rev. Toxicol., 19, 341-384.
2. Klein, C.B., Frenkel, K. and Costa, M. (1991) The role of oxidative processes in metal carcinogenesis. Chem. Res. Toxicol., 4, 592-604.
3. Lin, X., Sugiyama, M. and Costa, M. (1991) Differences in the effect of vitamin E on nickel sulfide or nickel chloride-induced chromosomal aberrations in mammalian cells. Mutat. Res., 260, 159-164.
4. Landolph, J.R. (1994) Molecular mechanisms of transformation of C3H/ 10T1/2 C1 8 mouse embryo cells and diploid human fibroblasts by carcinogenic metal compounds. Environ. Health Perspect., 102, 119-125.
5. Tkeshelashvili, L.K., Reid, T.M., McBride, T.J. and Loeb, L.A. (1993) Nickel induces a signature mutation for oxygen free radical damage. Cancer Res., 53, 4172-4174.
6. Costa, M., Zhuang, Z., Huang, X., Cosentino, S., Klein, C.B. and Salnokow, K. (1994) Molecular mechanisms of nickel carcinoaenesis. Sci. Total Environ., 148, 191-199.
7. Sunderman, F.W.J. (1993) Search for molecular mechanisms in the genotoxicity of nickel. Scand. J. Work Environ. Health, 19, 75-80.
8. Hartwig, A., Krüger, I. and Beyersmann, D. (1994) Mechanisms in nickel genotoxicity: the significance of interactions with DNA repair. Toxicol. Lett., 72, 353-358.
9. Hartwig, A. (1995) Current aspects in metal toxicology. BioMetals, 8, 3-11.
10. Tveito, G., Hansteen, I.-L., Dalen, H. and Haugen, A. (1989) Immortalization of normal human kidney epithelial cells by nickel(II). Cancer Res., 49, 1829-1835.
11. Moehle, L., Metcalf, R.A., Ryberg, D., Bennett, W.P., Harris, C.C. and Haugen, A. (1992) Altered p53 gene structure and expression in human epithelial cells after exposure to nickel. Cancer Res., 52, 218-221.
12. Haugen, A., Ryberg, D., Hansteen, I.-L. and Amstad, P. (1990) Neoplastic transformation of a human kidney epithelial cell line with v-Ha-ras oncogene. Int. J. Cancer, 45, 572-577.
13. Game, S.M., Stone, A., Scully, G. and Prime, S.S. (1990) Tumour progression in experimental oral carcinogenesis is associated with changes in EGF and TGF-β receptor expression and altered responses to these growth factors. Carcinogenesis, 11, 965-973.
14. Game, S.M., Huelsen, A., Patel, V., Donnelly, M., Yeudall, W.A., Stone, A., Fusenig, N.E. and Prime, S.S. (1992) Progressive abrogation of TGF-β1 and EGF growth control is associated with tumour progression in ras-transfected human keratinocytes. Int. J. Cancer, 52, 461-470.
15. Hubbs, A.F., Hahn, F.F. and Thomassen, D.G. (1989) Increased resistance to transforming growth factor beta accompanies neoplastic progression of rat tracheal epithelial cells. Carcinogenesis, 10, 1599-1605.
16. Carpenter, G. and Cohen, S. (1990) Epidermal growth factor. J. Biol. Chem., 265, 7709-7712.
17. Ullrich, A. and Schlessinger, J. (1990) Signal transduction by receptors with tyrosine kinase activity. Cell, 61, 203-212.
18. Schlessinger, J. and Ullrich, A. (1992) Growth factor signaling by receptor tyrosine kinases. Neuron, 9, 383-391.
19. van der Geer, P. and Hunter, T. (1994) Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell. Biol., 10, 251-337.
20. Libermann, T.A., Razon, N., Bartal, A.D., Yarden, Y., Schlessinger, J. and Soreq, H. (1984) Expression of epidermal growth factor receptors in human brain tumors. Cancer Res., 44, 753-760.
21. Bradley, S.J., Garfinkle, G., Walker, E., Salem, R., Chen, L.B. and Steele, G. (1986) Increased expression of the epidermal growth factor receptor on human colon carcinoma cells. Arch. Surg., 121, 1242-1247.
22. Bradley, S.J., Garfinkle, G., Walker, E., Salem, R.R., Bleday, R., Chen, L.B. and Steele, G.D. (1986) Increased epidermal growth factor receptor on human colon carcinoma cells without gene amplification. Surg. Forum, 37, 385-387.
23. Hendler, F.J. and Ozanne, B.W. (1984) Human squamous cell lung cancers express increased epidermal growth factor receptors. J. Clin. Invest., 74, 647-651.
24. Lacroix, H., Iglehart, J.D., Skinner, M.A. and Kraus, M.H. (1989) Overexpression of erbB-2 or EGF receptor proteins present in early stage mammary carcinoma is detected simultaneously in matched primary tumors and regional metastases. Oncogene, 4, 145-151.
25. Klijn, J.G.M., Berns, P.M.J.J., Schmitz, P.I.M. and Foekens, J.A. (1992) The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review of 5232 patients. Endocrine Rev., 13, 3-17.
26. Ishikawa, J., Maeda, S., Umezu, K.-I., Sugiyama, T. and Kamidono, S. (1990) Amplification and overexpression of the epidermal growth factor receptor gene in human renal-cell carcinoma. Int. J. Cancer, 45, 1018-1021.
27. Petrides, P.E., Bock, S., Bovens, J., Hofmann, R. and Jakse, G. (1990) Modulation of pro-epidermal growth factor, pro-transforming growth factor α and epidermal growth factor receptor gene expression in human renal carcinomas. Cancer Res., 50, 3934-3939.
28. Yao, M., Shuin, T., Misaki, H. and Kubota, Y. (1988) Enhanced expression of c-myc and epidermal growth factor receptor (c-erbB-1) genes in primary human renal cancer. Cancer Res., 48, 6753-6757.
29. Roberts, A.B. and Sporn, M.B. (1990) The transforming growth factor-βs. In Sporn, M.B. and Roberts, A.B. (eds), Peptide Growth Factors and their Receptors. Springer-Verlag, Berlin, pp. 419-472.
30. Massague, J. (1992) Receptors for the TGF-β family. Cell, 69, 1067-1070.
31. Wakefield, L.M., Smith, D.M., Masui, T., Harris, C.C. and Sporn, M.B. (1987) Distribution and modulation of the cellular receptor for transforming growth factor-beta. J. Cell Biol., 105, 965-975.
32. Laiho, M., DeCaprio, J.A., Ludlow, J.W., Livingston, D.M. and Massague, J. (1990) Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation. Cell, 62, 175-185.
33. Coffey, R.J., Bascom, C.C., Sipes, N.J., Graves-Deal, R., Weissman, B.E. and Moses, H.L. (1988) Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor β. Mol. Cell. Biol., 8, 3088-3093.
34. Pietenpol, J.A., Stein, R.W., Moran, E. et al. (1990) TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. Cell, 61, 777-785.
35. Satterwhite, D.J., Aakre, M.E., Gorska, A.E. and Moses, H.L. (1994) Inhibition of cell growth by TGFβ1 is associated with inhibition of B-myb and cyclin A in both BALB/MK and Mv1Lu cells. Cell Growth Diff., 5, 789-799.
36. Hannon, G.J. and Beach, D. (1994) p15INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature, 371, 257-261.
37. Roberts, A.B., Thompson, N.L., Heine, U., Flanders, C. and Sporn, M.B. (1988) Transforming growth factor-β: possible role in carcinogenesis. Br. J. Cancer, 57, 594-600.
38. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
39. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951) Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265-275.
40. Kamps, M.P. and Sefton, B.M. (1988) Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine. Oncogene, 2, 305-315.
41. Ross, A.H., Baltimore, D. and Eisen, H.N. (1981) Phosphotyrosine-containing proteins isolated by affinity chromatography with antibodies to a synthetic hapten. Nature, 294, 654-656.
42. Costa, M. (1991) Molecular mechanisms of nickel carcinogenesis. Annu. Rev. Pharmacol. Toxicol., 31, 321-337.
43. Klein, C.B., Conway, K., Wang, X.W., Bhamra, R.K., Lin, X., Cohen, M.D., Annab, L., Barrett, J.C. and Costa, M. (1991) Senescence of nickeltransformed cells by an X chromosome: possible epigenetic control. Science, 251, 796-799.
44. Hartwig, A., Mullenders, L.H.F. Schlepegrell, R., Kasten, U. and Beyersmann, D. (1994) Nickel(II) interferes with the incision step in nucleotide excision repair in mammalian cells. Cancer Res., 54, 4045-4051.
45. Weghorst, C.M., Dragnev, K.H., Buzard, G.S., Thorne, K.L., Vanderborne, G.F., Vincent, K.A. and Rice, J.M. (1994) Low incidence of point mutations detected in the p53 tumor suppressor gene from chemically induced rat renal mesenchymal tumors. Cancer Res., 54, 215-219.
46. Higginbotham, K.G., Rice, J.M., Diwan, B.A., Kasprzak, K.S., Reed, C.D. and Perantoni, A.O. (1992) GGT to GTT transversions in codon 12 of the K-ras oncogene in rat renal sarcomas induced with nickel subsulfide or nickel subsulfide/iron are consistent with oxidative damage to DNA. Cancer Res., 52, 4747-4751.
47. Lin, X., Dowjat, W.K. and Costa, M. (1994) Nickel-induced transformation of human cells causes loss of the phosphorylation of the retinoblastoma protein. Cancer Res., 54, 2751-2754.
48. Reddel, R.R., Ke, Y., Kaighn, M.E., Malan-Shibley, L., Lechner, J.F., Rhim, J.S. and Harris, C.C. (1988) Human bronchial epithelial cells neoplastically transformed by v-Ki-ras: altered response to inducers of terminal squamous differentiation. Oncogene Res., 3, 401-408.
49. Wyllie, F.S., Dawson, T., Bond, J.A., Goretzki, P., Game, S., Prime, S. and Wynford-Thomas, D. (1991) Correlated abnormalities of transforming growth factor-β1 response and p52 expression in thyroid epithelial cell transformation. Mol. Cell. Endocrinol., 76, 13-21.
50. 1. Proc. Natl Acad. Sci. USA, 89, 2759-2763.
51. Merlino, G.T., Ishii, S., Whang-Peng, J. et al. (1985) Structure and localization of genes encoding aberrant and normal epidermal growth factor receptor RNAs from A431 human carcinoma cells. Mol. Cell. Biol., 5, 1722-1734.
52. Assoian, R.K., Frolik, C.A., Roberts, A.B., Miller, D.M. and Spom, M.B. (1984) Transforming growth factor-β controls receptor levels for epidermal growth factor in NRK fibroblasts. Cell, 36, 35-41.
53. Assoian, R.K. (1985) Biphasic effect of type β transforming growth factor on epidermal growth factor receptors in NRK fibroblasts. J. Biol. Chem., 260, 9613-9617.
54. Takehara, K., Carwile LeRoy, E. and Grotendorst, G.R. (1987) TGF-β inhibition of endothelial cell proliferation: alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression. Cell, 49, 415-422.
55. Femandez-Pol, J.A., Hamilton, P.D. and Klos, D.J. (1989) Transcriptional regulation of proto-oncogene expression by epidermal growth factor, transforming growth factor beta 1, and triiodothyronine in MDA-468 cells. J. Biol. Chem., 264, 4151-4156.
56. Sharpe, P.M., Brunet, C.L. and Ferguson, M.W.J. (1992) Modulation of the epidermal growth factor receptor of mouse embryonic palatal mesenchyme cells in vitro by growth factors. Int. J. Dev. Biol., 36, 275-282.
57. Massague, J. (1985) Transformation growth factor-β modulates the high-affinity receptors for epidermal growth factor and transforming growth factor-α. J. Cell. Biol., 100, 1508-1514.
58. Like, B. and Massague, J. (1986) The antiproliferative effect of type β transforming growth factor occurs at a level distant from receptors for growth-activating factors. J. Biol. Chem., 261, 13426-13429.
59. Kawamoto, T., Mendelsohn, J., Le, A., Sato, G.H., Lazar, C.S. and Gill, G.N. (1984) Relation of epidermal growth factor receptor concentration to growth of human epidermoid carcinoma A431 cells. J. Biol. Chem., 259, 7761-7766.