Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells

Cell Division

Volumn 7, Issue , 2012, Pages

  Barra, Viviana ^a   Schillaci, Tiziana ^a   Lentini, Laura ^a   Costa, Giuseppe ^a   Di Leonardo, Aldo ^a,b  

^a UNIVERSITY OF PALERMO   (Italy)

^b Centro di Oncobiologia Sperimentale   (Italy)

Author keywords

Aneuploidy; DNA methylation; DNMT1; G1 arrest

Indexed keywords

EID: 84856474840     PISSN: None     EISSN: 17471028     Source Type: Journal    
DOI: 10.1186/1747-1028-7-2     Document Type: Article

References (35)

1. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998, 396(6712):643-649. 10.1038/25292, 9872311.
2. Lingle WL, Barrett SL, Negron VC, D'Assoro AB, Boeneman K, Liu W, Whitehead CM, Reynolds C, Salisbury JL. Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Acad Sci USA 2002, 99(4):1978-1983. 10.1073/pnas.032479999, 122305, 11830638.
3. Pihan GA, Doxsey SJ. The mitotic machinery as a source of genetic instability in cancer. Semin Cancer Biol 1999, 9(4):289-302. 10.1006/scbi.1999.0131, 10448116.
4. Fukasawa K. Centrosome amplification, chromosome instability and cancer development. Cancer Lett 2005, 230(1):6-19. 10.1016/j.canlet.2004.12.028, 16253756.
5. Lentini L, Pipitone L, Di Leonardo A. Functional inactivation of pRB results in aneuploid mammalian cells after release from a mitotic block. Neoplasia 2002, 4(5):380-387. 10.1038/sj.neo.7900256, 1661677, 12192596.
6. Hernando E, Nahle Z, Juan G, Diaz-Rodriguez E, Alaminos M, Hemann M, Michel L, Mittal V, Gerald W, Benezra R, Lowe SW, Cordon-Cardo C. Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature 2004, 430(7001):797-802. 10.1038/nature02820, 15306814.
7. Iovino F, Lentini L, Amato A, Di Leonardo A. RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts. Mol Cancer 2006, 5:38. 10.1186/1476-4598-5-38, 1613254, 16987420.
8. Herrera LA, Prada D, Andonegui MA, Duenas-Gonzalez A. The epigenetic origin of aneuploidy. Curr Genomics 2008, 9(1):43-50. 10.2174/138920208783884883, 2674307, 19424483.
9. Costello JF, Plass C. Methylation matters. J Med Genet 2001, 38(5):285-303. 10.1136/jmg.38.5.285, 1734882, 11333864.
10. Karpf AR, Matsui S. Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells. Cancer Res 2005, 65(19):8635-8639. 10.1158/0008-5472.CAN-05-1961, 16204030.
11. Luczak MW, Jagodzinski PP. The role of DNA methylation in cancer development. Folia Histochem Cytobiol 2006, 44(3):143-154.
12. Hervouet E, Lalier L, Debien E, Cheray M, Geairon A, Rogniaux H, Loussouarn D, Martin SA, Vallette FM, Cartron PF. Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells. PLoS One 2010, 5(6):e11333. 10.1371/journal.pone.0011333, 2894052, 20613874.
13. Burri N, Shaw P, Bouzourene H, Sordat I, Sordat B, Gillet M, Schorderet D, Bosman FT, Chaubert P. Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer. Lab Invest 2001, 81(2):217-229. 10.1038/labinvest.3780230, 11232644.
14. James SR, Link PA, Karpf AR. Epigenetic regulation of X-linked cancer/germline antigen genes by DNMT1 and DNMT3b. Oncogene 2006, 25(52):6975-6985. 10.1038/sj.onc.1209678, 16715135.
15. Chuang LS, Ian HI, Koh TW, Ng HH, Xu G, Li BF. Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. Science 1997, 277(5334):1996-2000. 10.1126/science.277.5334.1996, 9302295.
16. Wang S, El-Deiry WS. p73 or p53 directly regulates human p53 transcription to maintain cell cycle checkpoints. Cancer research 2006, 66(14):6982-6989. 10.1158/0008-5472.CAN-06-0511, 16849542.
17. Easwaran HP, Schermelleh L, Leonhardt H, Cardoso MC. Replication-independent chromatin loading of Dnmt1 during G2 and M phases. EMBO Rep 2004, 5(12):1181-1186. 10.1038/sj.embor.7400295, 1299190, 15550930.
18. Bestor TH. The DNA methyltransferases of mammals. Hum Mol Genet 2000, 9(16):2395-2402. 10.1093/hmg/9.16.2395, 11005794.
19. Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 2002, 16(1):6-21. 10.1101/gad.947102, 11782440.
20. Li E. Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet 2002, 3(9):662-673. 10.1038/nrg887, 12209141.
21. Hermann A, Gowher H, Jeltsch A. Biochemistry and biology of mammalian DNA methyltransferases. Cell Mol Life Sci 2004, 61(19-20):2571-2587. 10.1007/s00018-004-4201-1, 15526163.
22. Robertson KD. DNA methylation and human disease. Nat Rev Genet 2005, 6(8):597-610.
23. Shvachko LP. DNA hypomethylation as Achilles' heel of tumorigenesis: a working hypothesis. Cell Biol Int 2009, 33(8):904-910. 10.1016/j.cellbi.2009.02.018, 19446028.
24. Costa FF, Paixao VA, Cavalher FP, Ribeiro KB, Cunha IW, Rinck JA, O'Hare M, Mackay A, Soares FA, Brentani RR, Camargo AA. SATR-1 hypomethylation is a common and early event in breast cancer. Cancer Genet Cytogenet 2006, 165(2):135-143. 10.1016/j.cancergencyto.2005.07.023, 16527607.
25. Watanabe Y, Maekawa M. Methylation of DNA in cancer. Adv Clin Chem 2010, 52:145-167.
26. Zeimet AG, Fiegl H, Goebel G, Kopp F, Allasia C, Reimer D, Steppan I, Mueller-Holzner E, Ehrlich M, Marth C. DNA ploidy, nuclear size, proliferation index and DNA-hypomethylation in ovarian cancer. Gynecol Oncol 2011, 121(1):24-31. 10.1016/j.ygyno.2010.12.332, 3062717, 21251700.
27. Stimpson KM, Sullivan BA. Epigenomics of centromere assembly and function. Curr Opin Cell Biol 2010, 22(6):772-780. 10.1016/j.ceb.2010.07.002, 20675111.
28. Gieni RS, Chan GK, Hendzel MJ. Epigenetics regulate centromere formation and kinetochore function. J Cell Biochem 2008, 104(6):2027-2039. 10.1002/jcb.21767, 18404676.
29. de Plater L, Lauge A, Guyader C, Poupon MF, Assayag F, de Cremoux P, Vincent-Salomon A, Stoppa-Lyonnet D, Sigal-Zafrani B, Fontaine JJ, Brough R, Lord CJ, Ashworth A, Cottu P, Decaudin D, Marangoni E. Establishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation. Br J Cancer 2010, 103(8):1192-1200. 10.1038/sj.bjc.6605900, 2967069, 20877358.
30. Shukla V, Coumoul X, Lahusen T, Wang RH, Xu X, Vassilopoulos A, Xiao C, Lee MH, Man YG, Ouchi M, Ouchi T, Deng CX. BRCA1 affects global DNA methylation through regulation of DNMT1. Cell Res 2010, 20(11):1201-1215. 10.1038/cr.2010.128, 20820192.
31. De Marzo AM, Marchi VL, Yang ES, Veeraswamy R, Lin X, Nelson WG. Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis. Cancer Res 1999, 59(16):3855-3860.
32. Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW, Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998, 282(5393):1497-1501.
33. Frame FM, Rogoff HA, Pickering MT, Cress WD, Kowalik TF. E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts. Oncogene 2006, 25(23):3258-3266. 10.1038/sj.onc.1209352, 16434972.
34. Vivo M, Di Costanzo A, Fortugno P, Pollice A, Calabro V, La Mantia G. Downregulation of DeltaNp63alpha in keratinocytes by p14ARF-mediated SUMO-conjugation and degradation. Cell Cycle 2009, 8(21):3537-3543. 10.4161/cc.8.21.9935, 19829080.
35. Pereira MA, Wang W, Kramer PM, Tao L. DNA hypomethylation induced by non-genotoxic carcinogens in mouse and rat colon. Cancer Lett 2004, 212(2):145-151. 10.1016/j.canlet.2004.03.024, 15279894.