A biologically based dynamic model for predicting the disposition of methanol and its metabolites in animals and humans

Toxicological Sciences

Volumn 64, Issue 2, 2001, Pages 169-184

  Bouchard, Michèle ^a,b   Brunet, Robert C ^a   Droz, Pierre Olivier ^b   Carrier, Gaétan ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Animals; Formaldehyde; Formate; Humans; Methanol; Modeling; Toxicokinetics

Indexed keywords

FORMALDEHYDE; FORMIC ACID; METHANOL; TETRAHYDROFOLIC ACID;

ABSORPTION; ARTICLE; BIOLOGICAL MODEL; BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXCRETION; FEMALE; HALF LIFE TIME; HUMAN; LUNG; MALE; MATHEMATICAL COMPUTING; METABOLISM; MONKEY; NONHUMAN; PHYSICAL ACTIVITY; PREDICTION; RAT; SIMULATION; SPECIES DIFFERENCE; TOXICOKINETICS; URINE LEVEL;

AIR POLLUTANTS, OCCUPATIONAL; AIR POLLUTION; ANIMALS; FEMALE; FORMALDEHYDE; FORMIC ACIDS; HUMANS; INHALATION EXPOSURE; LUNG; MACACA FASCICULARIS; MALE; METHANOL; MODELS, BIOLOGICAL; PULMONARY VENTILATION; RATS; RATS, INBRED F344;

ANIMALIA;

EID: 0035199227     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/64.2.169     Document Type: Article

References (53)

1. Breath, urine, and blood measurements as biological exposure indices of short-term inhalation exposure to methanol
2. Occupational chronic exposure to organic solvents. VI. Formic acid concentration in blood and urine as an indicator of methanol exposure
3. Phase-specific developmental toxicity in mice following maternal methanol inhalation
4. A toxicokinetic model for predicting the tissue distribution and elimination of organic and inorganic mercury following exposure to methyl mercury in animals and humans. II. Application and validation of the model in humans
5. A toxicokinetic model to assess the risk of azinphosmethyl exposure in humans through measures of urinary elimination of alkylphosphates
6. Modeling of the toxicokinetics of polychlorinated dibenzo-p-dioxins and dibenzofurans in mammalians, including humans. I. Nonlinear distribution of PCDD/PCDF body burden between liver and adipose tissues
7. Modeling of the toxicokinetics of polychlorinated dibenzo-p-dioxins and dibenzofurans in mammalians, including humans. II. Kinetics of absorption and disposition of PCDDs/PCDFs
8. A toxicokinetic model for predicting the tissue distribution and elimination of organic and inorganic mercury following exposure to methyl the model using experimental data in rats
9. Formate in serum and urine after controlled methanol exposure at the threshold limit value
10. Toxicokinetic modeling of dose-dependent formate elimination in rats: In vivo-in vitro correlations using the perfused rat liver
11. 14C]formate in normal and folate-deficient cynomolgus monkeys
12. A case of percutaneous industrial methanol toxicity
13. Methanol monitoring. Comparison of urinary methanol concentration with formic acid excretion rate as a measure of occupational exposure
14. Analysis of respiratory exchange of methanol in the lung of the monkey using a physiological model
15. Breath monitoring of inhalation and dermal methanol exposure
16. Absence of formic acid accumulation in urine following five days of methanol exposure
17. The role of hepatic microbody and soluble oxidases in the peroxidation of methanol in the rat and monkey
18. Health Effects Institute Automotive Methanol Vapors and Human Health: An Evaluation of Existing Scientific Information and Issues for Future Research (a Special Report)
19. 14C] formaldehyde in rats after inhalation exposure
20. Occupational chronic exposure to organic solvents. X. Biological monitoring parameters for methanol exposure
21. Physiologically based pharmacokinetic model for methanol in rats, monkeys, and humans
22. Mechanisms of oxygen-induced lung injury
23. Environmental Health Criteria 196-Methanol
24. Methanol and formate kinetics in late diagnosed methanol intoxication
25. The toxicity of inhaled methanol vapors
26. Methanol in urine as a biological indicator of occupational exposure to methanol vapor
27. Toxicologic considerations in direct process spirit duplicating machines
28. A multi-centre study on completeness of urine collection in 11 European centres. I. Some problems with the use of creatinine and 4-aminobenzoic acid as marker of the completeness of collection
29. Lack of blood formate accumulation in humans following exposure to methanol vapor at the current permissible exposure limit of 200 ppm
30. Methanol and formic acid toxicity: Biochemical mechanisms
31. Methanol poisoning. V. Role of formate metabolism in the monkey
32. Lack of role for formaldehyde in methanol poisoning in the monkey
33. Pharmacokinetics of methanol and formate in female cynomolgus monkeys exposed to methanol vapors
34. Immunohistochemical localization of catalase in mammalian tissues
35. Teratological assessment of methanol and ethanol at high inhalation levels in rats
36. Toxicokinetic modelling of methyl formate exposure and implications for biological monitoring
37. Serum concentrations of methanol after inhalation at 200 ppm
38. Metabolism of formate in the rat
39. A pharmacokinetic model of inhaled methanol in humans and comparison to methanol disposition in mice and rats
40. Methanol inhalation: Site and other factors influencing absorption, and an inhalation toxicokinetic model for the rat
41. Maternal-fetal pharmacokinetics of methanol
42. Toxicokinetics of intravenous methanol in the female rat
43. Species differences in methanol poisonings
44. Biological monitoring of persons exposed to methanol vapours
45. Formate concentrations in plasma from patients poisoned with methanol
46. Tissue distribution of inhaled mercury vapor in acatalasemic mice
47. Methanol metabolism and toxicity
48. Methanol toxicity. Agency for Toxic Substances and Disease Registry
49. Development of a physiologically based pharmacokinetic model to describe the disposition of methanol in pregnant rats and mice
50. Comparative toxicokinetics of methanol in the female mouse and rat
51. Comparative toxicokinetics of methanol in pregnant and nonpregnant rodents
52. Formic acid excretion in comparison with methanol excretion in urine of workers occupationally exposed to methanol