A new approach for studying GPCR dimers: Drug-induced inactivation and reactivation to reveal GPCR dimer function in vitro, in primary culture, and in vivo

Pharmacology and Therapeutics

Volumn 133, Issue 2, 2012, Pages 205-217

  Teitler, Milt ^a   Klein, Michael T ^a,b  

^a ALBANY MEDICAL COLLEGE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

5 HT 2A; 5 HT 7; Allosterism; GPCR; Heterodimers; Homodimer

Indexed keywords

3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; BROMOCRIPTINE; CLOZAPINE; CYPROHEPTADINE; DIMER; G PROTEIN COUPLED RECEPTOR; HETERODIMER; HOMODIMER; LISURIDE; MESULERGINE; METERGOLINE; METITEPINE; MIANSERIN; MONOMER; RISPERIDONE; RITANSERIN; SEROTONIN 2A RECEPTOR; SEROTONIN 7 RECEPTOR;

ASTROCYTE; BINDING COMPETITION; COMPETITIVE INHIBITION; DRUG INACTIVATION; DRUG RECEPTOR BINDING; DRUG TARGETING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR INTERACTION; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PRIMARY CELL CULTURE; PRIORITY JOURNAL; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVIEW;

ALLOSTERIC SITE; ANIMALS; ASTROCYTES; HUMANS; MOLECULAR TARGETED THERAPY; PRIMARY CELL CULTURE; PROTEIN MULTIMERIZATION; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84856434606     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.10.007     Document Type: Review

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