Aluminum maltolate induces primary rat astrocyte apoptosis via overactivation of the class III PI3K/Beclin 1-dependent autophagy signal

Toxicology in Vitro

Volumn 26, Issue 2, 2012, Pages 215-220

  Zeng, Ke Wu ^a   Fu, Hong ^a   Liu, Geng Xin ^a   Wang, Xue Mei ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

Aluminum; Apoptosis; Astrocyte; Autophagy

Indexed keywords

3 METHYLADENINE; ALUMINUM MALTOL; BECLIN 1; CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; AUTOPHAGY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; NEUROTOXICITY; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ASTROCYTES; AUTOPHAGY; CASPASE 3; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; MICROTUBULE-ASSOCIATED PROTEINS; ORGANOMETALLIC COMPOUNDS; POLY(ADP-RIBOSE) POLYMERASES; PYRONES; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84856409526     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.11.010     Document Type: Article

References (39)

1. Alirezaei M., Kemball C.C., Lindsay W.J. Autophagy, inflammation and neurodegenerative disease. Eur. J. Neurosci. 2011, 33:197-204.
2. Altschuler E. Aluminum-containing antacids as a cause of idiopathic Parkinson's disease. Med. Hypotheses. 1999, 53:22-23.
3. Aremu D.A., Ezomo O.F., Meshitsuka S. Gene expression in primary cultured astrocytes affected by aluminum: alteration of chaperons involved in protein folding. Environ. Health Prev. Med. 2011, 16:16-24.
4. Banerjee R., Beal M.F., Thomas B. Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications. Trends Neurosci. 2010, 33:541-549.
5. Bharathi, Vasudevaraju P., Govindaraju M., et al. Molecular toxicity of aluminum in relation to neurodegeneration. Indian J. Med. Res. 2008, 128:545-556.
6. Campbell A., Hamai D., Bondy S.C. Differential toxicity of aluminum salts in human cell lines of neural origin: implications for neurodegeneration. Neurotoxicology 2001, 22:63-71.
7. Campbell A., Prasad K.N., Bondy S.C. Aluminum-induced oxidative events in cell lines: glioma are more responsive than neuroblastoma. Free Radic. Biol. Med. 1999, 26:1166-1171.
8. Canu N., Tufi R., Serafino A.L., Amadoro G., Ciotti M.T., Calissano P., et al. Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells. J. Neurochem. 2005, 92:1228-1242.
9. Cheng H.C., Kim S.R., Oo T.F., et al. Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy. J. Neurosci. 2011, 31:2125-2135.
10. Daido S., Kanzawa T., Yamamoto A., et al. Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res. 2004, 64:4286-4293.
11. Erazi H., Ahboucha S., Gamrani H. Chronic exposure to aluminum reduces tyrosine hydroxylase expression in the substantia nigra and locomotor performance in rats. Neurosci. Lett. 2011, 487:8-11.
12. Ferreira P.C., Piai Kde A., Takayanagui A.M., Segura-Muñoz S.I. Aluminum as a risk factor for Alzheimer's disease. Rev. Lat. Am. Enfermagem. 2008, 16:151-157.
13. Finnegan M.M., Rettig S.J., Orvig C. A neutral water-soluble aluminum complex of neurological interest. J. Am. Chem. Soc. 1986, 108:5033-5035.
14. Frisardi V., Solfrizzi V., Capurso C., et al. Aluminum in the diet and Alzheimer's disease: from current epidemiology to possible disease-modifying treatment. Alzheimers Dis. 2010, 20:17-30.
15. Fu H.J., Hu Q.S., Lin Z.N., et al. Aluminum-induced apoptosis in cultured cortical neurons and its effect on SAPK/JNK signal transduction pathway. Brain Res. 2003, 980:11-23.
16. Geeraert C., Ratier A., Pfisterer S.G., et al. Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation. J. Biol. Chem. 2010, 285:24184-24194.
17. Guo G.W., Liang Y.X. Aluminum-induced apoptosis in cultured astrocytes and its effect on calcium homeostasis. Brain Res. 2001, 888:221-226.
18. Kabeya Y., Mizushima N., Ueno T., et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000, 19:5720-5728.
19. Kang R., Zeh H.J., Lotze M.T., et al. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 2011, 18:571-580.
20. Kawahara M., Kato M., Kuroda Y. Effects of aluminum on the neurotoxicity of primary cultured neurons and on the aggregation of b-amyloid protein. Brain Res. Bull. 2001, 55:211-217.
21. Kroemer G., Levine B. Autophagic cell death: the story of a misnomer. Nat. Rev. Mol. Cell Biol. 2008, 9:1004-1010.
22. Kurz T., Gustafsson B., Brunk U.T. Cell sensitivity to oxidative stress is influenced by ferritin autophagy. Free Radic. Biol. Med. 2011, 50:1647-1658.
23. Lemire J., Mailloux R., Puiseux-Dao S., Appanna V.D. Aluminum-induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells. J. Neurosci. Res. 2009, 87:1474-1483.
24. Lé vesque L., Mizzen C.A., McLachlan D.R., Fraser P.E. Ligand specific effects on aluminum incorporation and toxicity in neurons and astrocytes. Brain Res. 2000, 877:191-202.
25. Liberski P.P., Sikorska B., Gibson P., Brown P., et al. Autophagy contributes to widespread neuronal degeneration in hamsters infected with the Echigo-1 strain of Creutzfeldt-Jakob disease and mice infected with the Fujisaki strain of Gerstmann-Sträussler-Scheinker (GSS) syndrome. Ultrastruct. Pathol. 2011, 35:31-36.
26. Niu P.Y., Niu Q., Zhang Q.L., et al. Aluminum impairs rat neural cell mitochondria in vitro. Int. J. Immunopathol. Pharmacol. 2005, 18:683-689.
27. Shacka J.J., Lu J., Xie Z.L., et al. Kainic acid induces early and transient autophagic stress in mouse hippocampus. Neurosci. Lett. 2007, 414:57-60.
28. Shaw C.A., Petrik M.S. Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration. J. Inorg. Biochem. 2009, 103:1555-1562.
29. Shea T.B., Clarke J.F., Wheelock T.R., et al. Aluminum salts induce the accumulation of neurofilaments in perikarya of NB2a/dl neuroblastoma. Brain Res. 1989, 492:53-64.
30. Tanida I. Autophagy basics. Microbiol. Immunol. 2011, 55:1-11.
31. Toimela T., Tähti H. Mitochondrial viability and apoptosis induced by aluminum, mercuric mercury and methylmercury in cell lines of neural origin. Arch. Toxicol. 2004, 78:565-574.
32. Tong J., Yan X., Yu L. The late stage of autophagy: cellular events and molecular regulation. Protein Cell. 2010, 1:907-915.
33. Van der Voet G.B., Marani E., Tio S., de Wolff F.A. Aluminium neurotoxicity. Prog. Histochem. Cytochem. 1991, 23:235-242.
34. Varner J.A., Jensen K.F., Horvath W., et al. Chronic administration of aluminum-fluoride or sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity. Brain Res. 1998, 784:284-298.
35. Walton J.R. Evidence for participation of aluminum in neurofibrillary tangle formation and growth in Alzheimer's disease. J. Alzheimers Dis. 2010, 22:65-72.
36. Xilouri M., Stefanis L. Autophagy in the central nervous system: implications for neurodegenerative disorders. CNS Neurol. Disord. Drug Targets. 2010, 9:701-719.
37. Yee K.S., Wilkinson S., James J., et al. PUMA-and Bax-induced autophagy contributes to apoptosis. Cell Death Differ. 2009, 16:1135-1145.
38. Zhang Q.L., Niu Q., Ji X.L., et al. Is necroptosis a death pathway in aluminum-induced neuroblastoma cell demise?. Int. J. Immunopathol. Pharmacol. 2008, 21:787-796.
39. Zhang Q.L., Niu Q., Niu P.Y., et al. Novel interventions targeting on apoptosis and necrosis induced by aluminum chloride in neuroblastoma cells. J. Biol. Regul. Homeost. Agents 2010, 24:137-148.