CYR61 Modulates the Vascular Endothelial Growth Factor C Expression of Decidual NK Cells Via PI3K/AKT Pathway

American Journal of Reproductive Immunology

Volumn 67, Issue 3, 2012, Pages 216-223

  Zhang, Xindong ^a   Ding, Lijun ^a   Diao, Zhenyu ^a   Yan, Guijun ^a   Sun, Haixiang ^a   Hu, Yali ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

CYR61; DNK; Integrin v 3; Vascular endothelial growth factor C

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CD56 ANTIGEN; CYSTEINE RICH PROTEIN 61; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UO 126; VASCULOTROPIN C; VITRONECTIN RECEPTOR;

ARTICLE; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; DECIDUA; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

CYSTEINE-RICH PROTEIN 61; DECIDUA; FEMALE; HUMANS; INTEGRIN ALPHAVBETA3; KILLER CELLS, NATURAL; PRE-ECLAMPSIA; PREGNANCY; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 84856403168     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2011.01080.x     Document Type: Article

References (29)

1. Le Bouteiller P, Tabiasco J: Killers become builders during pregnancy. Nat Med 2006; 12:991-992.
2. Moffett-King A: Natural killer cells and pregnancy. Nat Rev Immunol 2002; 2:656-663.
3. Hanna J, Goldman-Wohl D, Hamani Y, Avraham I, Greenfield C, Natanson-Yaron S, Prus D, Cohen-Daniel L, Arnon TI, Manaster I, Gazit R, Yutkin V, Benharroch D, Porgador A, Keshet E, Yagel S, Mandelboim O: Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nat Med 2006; 12:1065-1074.
4. Kalkunte SS, Mselle TF, Norris WE, Wira CR, Sentman CL, Sharma S: Vascular endothelial growth factor C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface. J Immunol 2009; 182:4085-9402.
5. Dhar A, Ray A: The CCN family proteins in carcinogenesis. Exp Oncol 2010; 32:2-9.
6. Redman CW, Sargent IL: Latest advances in understanding preeclampsia. Science 2005; 308:1592-1594.
7. Zhang Y, Diao Z, Su L, Sun H, Li R, Cui H, Hu Y: MicroRNA-155 contributes to preeclampsia by down-regulating CYR61. Am J Obstet Gynecol 2010; 202:466.
8. Hu Y, Dutz JP, MacCalman CD, Yong P, Tan R, von Dadelszen P: Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: a role for IFN-gamma. J Immunol 2006; 177:8522-8530.
9. Hu YL, Zhou JJ, Hao S, Wang ZQ, Dai YM, Ling JX, Hou YY: Changes in the ratio of Tc1/Tc2 cells but not in subtypes of NK-cells in preeclampsia. Int J Mol Sci 2007; 8:492-504.
10. Plevyak M, Hanna N, Mayer S, Murphy S, Pinar H, Fast L, Ekerfelt C, Ernerudh J, Berg G, Matthiesen L, Sharma S: Deficiency of decidual IL-10 in first trimester missed abortion: a lack of correlation with the decidual immune cell profile. Am J Reprod Immunol 2002; 47:242-250.
11. Ding Z, Lambrechts A, Parepally M, Roy P: Silencing profilin-1 inhibits endothelial cell proliferation, migration and cord morphogenesis. J Cell Sci 2006; 119:4127-4137.
12. Menendez JA, Vellon L, Mehmi I, Teng PK, Griggs DW, Lupu R: A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway. Oncogene 2005; 24:761-779.
13. Tsai MS, Hornby AE, Lakins J, Lupu R: Expression and function of CYR61, an angiogenic factor, in breast cancer cell lines and tumor biopsies. Cancer Res 2000; 60:5603-5607.
14. Zimmermann S, Moelling K: Phosphorylation and regulation of Raf by Akt (protein kinase B). Science 1999; 286:1741-1744.
15. Wolf N, Yang W, Dunk CE, Gashaw I, Lye SJ, Ring T, Schmidt M, Winterhager E, Gellhaus A: Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast. Endocrinology 2010; 151:2835-2845.
16. Levine RJ, Thadhani R, Qian C, Lam C, Lim KH, Yu KF, Blink AL, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA: Urinary placental growth factor and risk of preeclampsia. JAMA 2005; 293:77-85.
17. Koopman LA, Kopcow HD, Rybalov B, Boyson JE, Orange JS, Schatz F, Masch R, Lockwood CJ, Schachter AD, Park PJ, Strominger JL: Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J Exp Med 2003; 198:1201-1212.
18. Joukov V, Kaipainen A, Jeltsch M, Pajusola K, Olofsson B, Kumar V, Eriksson U, Alitalo K: Vascular endothelial growth factors VEGF-B and VEGF-C. J Cell Physiol 1997; 173:211-215.
19. Dunk C, Ahmed A: Expression of VEGF-C and activation of its receptors VEGFR-2 and VEGFR-3 in trophoblast. Histol Histopathol 2001; 16:359-375.
20. Li XF, Charnock-Jones DS, Zhang E, Hiby S, Malik S, Day K, Licence D, Bowen JM, Gardner L, King A, Loke YW, Smith SK: Angiogenic growth factor messenger ribonucleic acids in uterine natural Killer cells. J Clin Endocrinol Metab 2001; 86:1823-1834.
21. Saito S, Nishikawa K, Morii T, Enomoto M, Narita N, Motoyoshi K, Ichijo M: Cytokine production by CD16- CD56 bright natural killer cells in the early pregnancy decidua. Int Immunol 1993; 5:559-563.
22. Hu W, Wang H, Wang Z, Huang H, Dong M: Elevated serum levels of interleukin-15 and interleukin-16 in preeclampsia. J Reprod Immunol 2007; 73:166-171.
23. Chen CC, Lau LF: Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol 2009; 41:771-783.
24. Giancotti FG, Ruoslahti E: Integrin signaling. Science 1999; 285:1028-1032.
25. Mo FE, Muntean AG, Chen CC, Stolz DB, Watkins SC, Lau LF: CYR61 (CCN1) is essential for placental development and vascular integrity. Mol Cell Biol 2002; 22:8709-8720.
26. Rabinowich H, Lin WC, Amoscato A, Herberman RB, Whiteside TL: Expression of vitronectin receptor on human NK cells and its role in protein phosphorylation, cytokine production, and cell proliferation. J Immunol 1995; 154:1124-1135.
27. Kim N, Saudemont A, Webb L, Camps M, Ruckle T, Hirsch E, Turner M, Colucci F: The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion. Blood 2007; 110:3202-3208.
28. Burrows TD, King A, Loke YW: Trophoblast migration during human placental implantation. Hum Reprod Update 1996; 2:307-321.
29. Hu Y, Eastabrook G, Tan R, MacCalman CD, Dutz JP, von Dadelszen P: Decidual NK cell-derived conditioned medium enhances capillary tube and network organization in an extravillous cytotrophoblast cell line. Placenta 2010; 31:213-221.