Familial aggregation of allergen-specific sensitization and asthma

Pediatric Allergy and Immunology

Volumn 23, Issue 1, 2012, Pages 21-27

  Kurzius Spencer, Margaret ^a,b   Guerra, Stefano ^b,c   Sherrill, Duane L ^a,b   Halonen, Marilyn ^b,d   Elston, Robert C ^e   Martinez, Fernando D ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^d UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Asthma; Atopy; Familial aggregation; Specific response to allergens

Indexed keywords

ALLERGEN;

ADULT; AGED; ARTICLE; ASTHMA; ATOPY; CHILD; CORRELATION ANALYSIS; FAMILY; FEMALE; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; OBSTRUCTIVE AIRWAY DISEASE; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SENSITIZATION; SIBLING; SKIN TEST;

ADOLESCENT; ADULT; ALLERGENS; ANIMALS; ASTHMA; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; ENVIRONMENTAL EXPOSURE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; MALE; MIDDLE AGED; PEDIGREE; PLANT WEEDS; PREVALENCE; PYROGLYPHIDAE; QUESTIONNAIRES; SKIN TESTS;

EID: 84856399410     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2011.01220.x     Document Type: Article

References (30)

1. Blumenthal MN, Namboodiri K, Mendell N, Gleich G, Elston RC, Yunis E. Genetic transmission of serum IgE Levels. Am J Med Genet 1981: 10: 219-28.
2. Lebowitz MD, Barbee R, Burrows B. Family concordance of IgE, atopy, and disease. J Allergy Clin Immunol 1984: 73: 259-64.
3. Hanson B, McGue M, Roitman-Johnson B, Segal NL, Bouchard TJ Jr, Blumenthal MN. Atopic disease and immunoglobulin E in twins reared apart and together. Am J Hum Genet 1991: 48: 873-9.
4. Strachan DP, Wong HJ, Spector TD. Concordance and interrelationship of atopic diseases and markers of allergic sensitization among adult female twins. J Allergy Clin Immunol 2001: 108: 901-7.
5. Liu X, Zhang S, Tsai HJ, et al. Genetic and environmental contributions to allergen sensitization in a Chinese twin study. Clin Exp Allergy 2009: 39: 991-8.
6. Koppelman GH, Stine OC, Xu J, et al. Genome-wide search for atopy susceptibility genes in Dutch families with asthma. J Allergy Clin Immunol 2002: 109: 498-506.
7. Holberg CJ, Elston RC, Halonen M, et al. Segregation analysis of physician-diagnosed asthma in Hispanic and non-Hispanic white families. A recessive component? Am J Respir Crit Care Med 1996: 154: 144-50.
8. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 2008: 8: 169-82.
9. Wan YI, Strachan DP, Evans DM, et al. A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom. J Allergy Clin Immunol 2011: 127: 223-31, 231.e1-3.
10. Martinez FD. Genes, environments, development and asthma: a reappraisal. Eur Respir J 2007: 29: 179-84.
11. Simpson A, Tan VY, Winn J, et al. Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study. Am J Respir Crit Care Med 2010: 181: 1200-6.
12. Jackola DR, Liebeler CL, Blumenthal MN, Rosenberg A. Random outcomes of allergen-specific responses in atopic families. Clin Exp Allergy 2004: 34: 540-7.
13. Sherrill D, Stein R, Kurzius-Spencer M, Martinez F. On early sensitization to allergens and development of respiratory symptoms. Clin Exp Allergy 1999: 29: 905-11.
14. Halonen M, Stern DA, Wright AL, Taussig LM, Martinez FD. Alternaria as a major allergen for asthma in children raised in a desert environment. Am J Respir Crit Care Med 1997: 155: 1356-61.
15. Platts-Mills TA, Chapman MD, Pollart S, Luczynska CM, Ward GW Jr. Specific allergens evoking immune reactions in the lung: relationship to asthma. Eur Respir J Suppl 1991: 13: 68s-77s.
16. Salo PM, Arbes SJ Jr, Sever M, et al. Exposure to Alternaria alternata in US homes is associated with asthma symptoms. J Allergy Clin Immunol 2006: 118: 892-8.
17. Taussig LM, Wright AL, Morgan WJ, Harrison HR, Ray CG. The Tucson Children's Respiratory Study. I. Design and implementation of a prospective study of acute and chronic respiratory illness in children. Am J Epidemiol 1989: 129: 1219-31.
18. Lebowitz MD, Knudson RJ, Burrows B. Tucson epidemiologic study of obstructive lung diseases. I: methodology and prevalence of disease. Am J Epidemiol 1975: 102: 137-52.
19. Barbee RA, Kaltenborn W, Lebowitz MD, Burrows B. Longitudinal changes in allergen skin test reactivity in a community population sample. J Allergy Clin Immunol 1987: 79: 16-24.
20. S.A.G.E. Statistical Analysis for Genetic Epidemiology (S.A.G.E.) Version 6.1.0. User Reference Manual. S.A.G.E., 2010.
21. Keen KJ, Elston RC. Robust asymptotic sampling theory for correlations in pedigrees. Stat Med 2003: 22: 3229-47.
22. Stern DA, Lohman IC, Wright AL, Taussig LM, Martinez FD, Halonen M. Dynamic changes in sensitization to specific aeroallergens in children raised in a desert environment. Clin Exp Allergy 2004: 34: 1563-9.
23. Hoffjan S, Nicolae D, Ober C. Association studies for asthma and atopic diseases: a comprehensive review of the literature. Respir Res 2003: 4: 14.
24. Manolio TA, Barnes KC, Beaty TH, Levett PN, Naidu RP, Wilson AF. Sex differences in heritability of sensitization to Blomia tropicalis in asthma using regression of offspring on midparent (ROMP) methods. Hum Genet 2003: 113: 437-46.
25. Liebeler CL, Basu S, Jackola DR. Allergen-specific IgG1 provides parsimonious heritability estimates for atopy-associated immune responses to allergens. Hum Immunol 2007: 68: 113-21.
26. Jackola DR, Blumenthal MN, Rosenberg A. Evidence for two independent distributions of serum immunoglobulin E in atopic families: cognate and non-cognate IgE. Hum Immunol 2004: 65: 20-30.
27. Jackola DR. Random allergen-specific IgE expression in atopic families: evidence for inherited "stochastic bias" in adverse immune response development to non-infectious antigens. Mol Immunol 2007: 44: 2549-57.
28. Boitano S, Flynn AN, Sherwood CL, et al. Alternaria alternata serine proteases induce lung inflammation and airway epithelial cell activation via PAR2. Am J Physiol Lung Cell Mol Physiol 2011: 300: L605-14.
29. Moffatt MF, Gut IG, Demenais F, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010: 363: 1211-21.
30. Kurz T, Strauch K, Heinzmann A, et al. A European study on the genetics of mite sensitization. J Allergy Clin Immunol 2000: 106: 925-32.