In vitro characterization of rosiglitazone metabolites and determination of the kinetic parameters employing rat liver microsomal fraction

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 36, Issue 3, 2011, Pages 159-166

  Calixto, Leandro Augusto ^a   De Oliveira, Anderson Rodrigo Moraes ^a   Jabor, Valquíria Aparecida Polisel ^a   Bonato, Pierina Sueli ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

In vitro metabolism; Metabolite identification; Rat liver microsomal fraction; Rosiglitazone

Indexed keywords

4 HYDROXY ROSIGLITAZONE; DRUG METABOLITE; N DESMETHYL ROSIGLITAZONE; ROSIGLITAZONE; UNCLASSIFIED DRUG; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG METABOLISM; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME KINETICS; IN VITRO STUDY; LIMIT OF QUANTITATION; LIVER MICROSOME; MALE; METABOLIC RATE; MICHAELIS MENTEN KINETICS; NONHUMAN; RAT; ANIMAL; DEALKYLATION; METABOLIC CLEARANCE RATE; METABOLISM; REGRESSION ANALYSIS; WISTAR RAT;

ANIMALS; DEALKYLATION; HYPOGLYCEMIC AGENTS; MALE; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; RATS; RATS, WISTAR; REGRESSION ANALYSIS; THIAZOLIDINEDIONES;

EID: 84856397714     PISSN: 03787966     EISSN: 21070180     Source Type: Journal    
DOI: 10.1007/s13318-011-0039-8     Document Type: Article

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