Simultaneous determination of rosiglitazone and its metabolites in rat liver microsomal fraction using hollow-fiber liquid-phase microextraction for sample preparation

Journal of Separation Science

Volumn 33, Issue 17-18, 2010, Pages 2872-2880

  Calixto, Leandro Augusto ^a   Bonato, Pierina Sueli ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Biotransformation study; Hollow fiber liquid phase microextraction; HPLC; Microsomes; Rosiglitazone

Indexed keywords

BIOTRANSFORMATION STUDY; HOLLOW FIBER; HPLC; MICROSOMES; ROSIGLITAZONE;

ACETONITRILE; BIOCONVERSION; BIOMOLECULES; FIBERS; HYDROCHLORIC ACID; LIQUIDS; LIVER; METABOLISM; METABOLITES; OPTIMIZATION;

SOLVENT EXTRACTION;

ACETIC ACID; ACETONITRILE; DRUG METABOLITE; HYDROCHLORIC ACID; N DESMETHYL ROSIGLITAZONE; OCTANOL; PARA HYDROXY ROSIGLITAZONE; ROSIGLITAZONE; UNCLASSIFIED DRUG; WATER;

ACCURACY; ARTICLE; CORRELATION COEFFICIENT; DRUG STRUCTURE; DRUG TRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOLLOW FIBER; IN VITRO STUDY; LIQUID PHASE MICROEXTRACTION; LIVER MICROSOME; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; VALIDATION PROCESS;

ANIMALS; BIOTRANSFORMATION; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, LIQUID; HYPOGLYCEMIC AGENTS; LIVER EXTRACTS; MALE; MICROSOMES, LIVER; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLVENTS; THIAZOLIDINEDIONES;

RATTUS;

EID: 77956900966     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201000380     Document Type: Article

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