New grading criteria allow for earlier detection of geographic atrophy in clinical trials

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 12, 2011, Pages 9218-9225

  Brader, Hilary Smolen ^a   Ying, Gui Shuang ^a   Revell Martin, E ^a   Maguire, Maureen G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ARTICLE; DISEASE CLASSIFICATION; EYE FUNDUS; EYE PHOTOGRAPHY; FLUORESCENCE ANGIOGRAPHY; FOLLOW UP; GEOGRAPHIC ATROPHY; GRADING CRITERIA; HUMAN; MAJOR CLINICAL STUDY; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RELIABILITY; CLASSIFICATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; LABORATORY DIAGNOSIS; LASER COAGULATION; MULTICENTER STUDY; OBSERVER VARIATION; PATHOPHYSIOLOGY; PHYSIOLOGY; PREDICTIVE VALUE; RANDOMIZED CONTROLLED TRIAL; REPRODUCIBILITY; TIME; VISUAL ACUITY; VISUAL DISORDER;

FALSE POSITIVE REACTIONS; FLUORESCEIN ANGIOGRAPHY; FOLLOW-UP STUDIES; GEOGRAPHIC ATROPHY; HUMANS; LASER COAGULATION; OBSERVER VARIATION; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; TIME FACTORS; VISION DISORDERS; VISUAL ACUITY;

EID: 84856394037     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7493     Document Type: Article

References (42)

1. Friedman DS, O'Colmain BJ, Muñoz B, et al. Eye Diseases Prevalence Research Group. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol. 2004;122: 564-572.
2. Rein DB, Wittenborn JS, Zhang X, et al. Vision Health Cost-Effectiveness Study Group. Forecasting age-related macular degeneration through the year 2050: the potential impact of new treatments. Arch Ophthalmol. 2009;127:533-540.
3. Solomon SD, Sunness JS. Geographic atrophy. In: Lim JI, ed. Age-Related Macular Degeneration. 2nd ed. New York: Informa Healthcare; 2008;111-123.
4. McLeod DS, Taomoto M, Otsuji T, et al. Quantifying changes in RPE and choroidal vasculature in eyes with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2002;43(6):1986-1993.
5. Sunness JS. The natural history of geographic atrophy, the advanced atrophic form of age-related macular degeneration. Mol Vis. 1999;5:25.
6. Klein ML, Ferris FL 3rd, Armstrong J, et al. AREDS Research Group. Retinal precursors and the development of geographic atrophy in age-related macular degeneration. Ophthalmology. 2008;115: 1026-1031.
7. Fleckenstein M, Schmitz-Valckenberg S, Adrion C, et al. Tracking progression with spectral-domain optical coherence tomography in geographic atrophy caused by age-related macular degeneration. Invest Ophthalmol Vis Sci. 2010;51:3846-3852.
8. Fleckenstein M, Adrion C, Schmitz-Valckenberg S, et al. Concordance of disease progression in bilateral geographic atrophy due to AMD. Invest Ophthalmol Vis Sci. 2010;51:637-642.
9. Holz FG, Bellman C, Staudt S, et al. Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2001;42:1051-1056.
10. Klein R, Davis MD, Magli YL, et al. The Wisconsin age-related maculopathy grading system. Ophthalmology. 1991;98:1128-1134.
11. Age-Related Eye Disease Study Research Group. The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study Report Number 6. Am J Ophthalmol. 2001;132:668-681.
12. Complications of Age-Related Macular Degeneration Prevention Trial Research Group. Laser treatment in patients with bilateral large drusen: the complications of age-related macular degeneration prevention trial. Ophthalmology. 2006;113:1974-1986.
13. Klein R, Klein BE, Jensen SC, Meuer SM. The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology. 1997;104:7-21.
14. Klaver CC, Assink JJ, van Leeuwen R, et al. Incidence and progression rates of age-related maculopathy: the Rotterdam Study. Invest Ophthalmol Vis Sci. 2001;42:2237-2241.
15. Mitchell P, Wang JJ, Foran S, Smith W. Five-year incidence of age-related maculopathy lesions: the Blue Mountains Eye Study. Ophthalmology. 2002;109:1092-1097.
16. Sunness JS, Gonzalez-Baron J, Applegate CA, et al. Enlargement of atrophy and visual acuity loss in the geographic atrophy form of age-related macular degeneration. Ophthalmology. 1999;106: 1768-1779.
17. Sunness JS, Margalit E, Srikumaran D, et al. The long-term natural history of geographic atrophy from age-related macular degeneration: enlargement of atrophy and implications for interventional clinical trials. Ophthalmology. 2007;114:271-277.
18. Sunness JS, Bressler NM, Tian Y, et al. Measuring geographic atrophy in advanced age-related macular degeneration. Invest Ophthalmol Vis Sci. 1999;40:1761-1769.
19. Bird AC, Bressler NM, Bressler SB, et al. The International ARM Epidemiological Study Group. An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv Ophthalmol. 1995;39:367-374.
20. Hartmann KI, Bartsch DUG, Cheng L, et al. Scanning laser ophthalmoscope imaging stabilized microperimetry in dry age-related macular degeneration. Retina. 2011;31:1323-1331.
21. Meleth AD, Mettu P, Agron E, et al. Changes in retinal sensitivity in geographic atrophy progression as measured by microperimetry. Invest Ophthalmol Vis Sci. 2011;52:1119-1126.
22. von Ruckmann A, Fitzke FW, Bird AC. Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci. 1997;38:478-486.
23. Bearelly S, Cousins SW. Fundus autofluorescence imaging in agerelated macular degeneration and geographic atrophy. Adv Exp Med Biol. 2010;664:395-402.
24. Holz FG, Bellmann C, Margaritidis M, et al. Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with agerelated macular degeneration. Graefes Arch Clin Exp Ophthalmol. 1999;237:145-152.
25. Bearelly S, Chau FY, Koreishi A, et al. Spectral domain optical coherence tomography imaging of geographic atrophy margins. Ophthalmology. 2009;116:1762-1769.
26. Spaide RF, Eter N. Fundus Angiography: Nonneovascular age-related macular degeneration. In: Holz FG, Bindewald A, Pauleikhoff D, et al., eds. Age-Related Macular Degeneration. Heidelberg, Germany: Springer-Verlag; 2004;94-96.
27. Coscas G, Coscas F, Zourdani A. Atlas of Indocyanine Green Angiography: Fluorescein Angiography, ICG Angiography and OCT Correlations. Paris, France: Elsevier SAS: 2005;172-179.
28. Johnson TM, Johnson MW. Macular diseases: age-related macular degeneration: nonexudative. In: Quillen DA, Blodi BA, eds. Clinical Retina. Chicago: AMA Press. 2002;86-89.
29. Fleiss JL. The measurement of interrater agreement. Statistical Methods for Rates and Proportions. 3rd ed. New York: Wiley; 2003.
30. Sunness JS, Applegate CA, Bressler NM, Hawkins BS. Designing clinical trials for age-related geographic atrophy of the macula: enrollment data from the geographic atrophy natural history study. Retina. 2007;27:204-210.
31. Spaide RF, Eter N. Fundus angiography: non-neovascular age-related macular degeneration. In: Holz FG, Bindewald A, Pauleikhoff D, et al., eds. Age-Related Macular Degeneration. Heidelberg, Germany: Springer-Verlag; 2004;96.
32. Coscas G, Coscas F, Zourdani A. Atlas of Indocyanine Green Angiography: Fluorescein Angiography, ICG Angiography and OCT Correlations. Paris, France: Elsevier SAS; 2005;82.
33. Holz FG, Bindewald-Wittich A, Fleckenstein M, et al. FAM-Study Group. Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. Am J Ophthalmol. 2007;143:463-472.
34. Schmitz-Valckenberg S, Jorzik J, Unnebrink K, Holz FG, FAM Study Group. Analysis of digital scanning laser ophthalmoscopy fundus autofluorescence images of geographic atrophy in advanced agerelated macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2002;240:73-78.
35. Schmitz-Valckenberg S, Bindewald-Wittich A, Dolar-Szczasny J, et al. Fundus Autofluorescence in Age-Related Macular Degeneration Study Group. Correlation between the area of increased autofluorescence surrounding geographic atrophy and disease progression in patients with AMD. Invest Ophthalmol Vis Sci. 2006;47:2648-2654.
36. Dreyhaupt J, Mansmann U, Pritsch M, et al. Modelling the natural history of geographic atrophy in patients with agerelated macular degeneration. Ophthalmic Epidemiol. 2005;12: 353-362.
37. Brar M, Kozak I, Cheng L, et al. Correlation between spectraldomain optical coherence tomography and fundus autofluorescence at margins of geographic atrophy. Am J Ophthalmology. 2009;143:439-444.
38. Schmitz-Valckenberg S, Fleckenstein M, Gobel AP, Hohman TC, Holz FG. Optical coherence tomography and autofluorescence findings in area with geographic atrophy due to age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011;52:1-6.
39. Kellner U, Kellner S, Weinitz S. Fundus autofluorescence (488 nm) and near-infrared autofluorescence (787 nm) visualize different retinal pigment epithelium alterations in patients with age-related macular degeneration. Retina. 2010;30:6-15.
40. Sunness JS, Ziegler MD, Applegate CA. Issues in quantifying atrophic macular disease using retinal autofluorescence. Retina. 2006; 26:666-672.
41. Wolf-Schnurrbusch UEK, Enzmann V, Brinkmann CK, Wolf S. Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination. Invest Ophthalmol Vis Sci. 2008;49:3095-3099.
42. Sunness JS, Rubin GS, Applegate CA, Bressler NM, et al. Visual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuity. Ophthalmology. 1997;104:1677-1691.