-
1
-
-
0034924823
-
Mechanisms of viral membrane fusion and its inhibition
-
Eckert DM, Kim PS. Mechanisms of viral membrane fusion and its inhibition. Annu Rev Biochem 2001; 70:777-810.
-
(2001)
Annu Rev Biochem
, vol.70
, pp. 777-810
-
-
Eckert, D.M.1
Kim, P.S.2
-
2
-
-
0032433685
-
Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target
-
Chan DC, Chutkowski CT, Kim PS. Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target. Proc Natl Acad Sci USA 1998; 95:15613-15617.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 15613-15617
-
-
Chan, D.C.1
Chutkowski, C.T.2
Kim, P.S.3
-
3
-
-
0032483021
-
Crystal structure of the simian immunodefciency virus (SIV) gp41 core: Conserved helical interactions underlie the broad inhibitory activity of gp41 peptides
-
Malashkevich VN, Chan DC, Chutkowski CT, Kim PS. Crystal structure of the simian immunodefciency virus (SIV) gp41 core: conserved helical interactions underlie the broad inhibitory activity of gp41 peptides. Proc Natl Acad Sci USA 1998; 95:9134-9139.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 9134-9139
-
-
Malashkevich, V.N.1
Chan, D.C.2
Chutkowski, C.T.3
Kim, P.S.4
-
4
-
-
0030970693
-
Core structure of gp41 from the HIV envelope glycoprotein
-
Chan DC, Fass D, Berger JM, Kim PS. Core structure of gp41 from the HIV envelope glycoprotein. Cell 1997; 89:263-273.
-
(1997)
Cell
, vol.89
, pp. 263-273
-
-
Chan, D.C.1
Fass, D.2
Berger, J.M.3
Kim, P.S.4
-
5
-
-
16844383101
-
The tryptophan-rich region of HIV gp41 and the promotion of cholesterol-rich domains
-
Epand RF, Sayer BG, Epand RM. The tryptophan-rich region of HIV gp41 and the promotion of cholesterol-rich domains. Biochemistry 2005; 44:5525-5531.
-
(2005)
Biochemistry
, vol.44
, pp. 5525-5531
-
-
Epand, R.F.1
Sayer, B.G.2
Epand, R.M.3
-
6
-
-
0032980413
-
A conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity
-
Salzwedel K, West JT, Hunter E. A conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity. J Virol 1999; 73:2469-2480.
-
(1999)
J Virol
, vol.73
, pp. 2469-2480
-
-
Salzwedel, K.1
West, J.T.2
Hunter, E.3
-
7
-
-
0035859948
-
The membrane-proximal tryptophan-rich region of the HIV glycoprotein, gp41, forms a well-defined helix in dodecylphosphocholine micelles
-
Schibli DJ, Montelaro RC, Vogel HJ. The membrane-proximal tryptophan-rich region of the HIV glycoprotein, gp41, forms a well-defined helix in dodecylphosphocholine micelles. Biochemistry 2001; 40:9570-9578.
-
(2001)
Biochemistry
, vol.40
, pp. 9570-9578
-
-
Schibli, D.J.1
Montelaro, R.C.2
Vogel, H.J.3
-
8
-
-
43949135190
-
Importance of the membrane-perturbing properties of the membrane-proximal external region of human immunodeficiency virus type 1 gp41 to viral fusion
-
Vishwanathan SA, Hunter E. Importance of the membrane-perturbing properties of the membrane-proximal external region of human immunodeficiency virus type 1 gp41 to viral fusion. J Virol 2008; 82:5118-5126.
-
(2008)
J Virol
, vol.82
, pp. 5118-5126
-
-
Vishwanathan, S.A.1
Hunter, E.2
-
9
-
-
0037936885
-
C-terminal octylation rescues an inactive T20 mutant: Implications for the mechanism of HIV/SIMIAN immunodeficiency virus-induced membrane fusion
-
Peisajovich SG, Gallo SA, Blumenthal R, Shai Y. C-terminal octylation rescues an inactive T20 mutant: implications for the mechanism of HIV/SIMIAN immunodeficiency virus-induced membrane fusion. J Biol Chem 2003; 278:21012-21017.
-
(2003)
J Biol Chem
, vol.278
, pp. 21012-21017
-
-
Peisajovich, S.G.1
Gallo, S.A.2
Blumenthal, R.3
Shai, Y.4
-
10
-
-
39149127330
-
Design of a novel HIV-1 fusion inhibitor that displays a minimal interface for binding affinity
-
Oishi S, Ito S, Nishikawa H, et al. Design of a novel HIV-1 fusion inhibitor that displays a minimal interface for binding affinity. J Med Chem 2008; 51:388-391.
-
(2008)
J Med Chem
, vol.51
, pp. 388-391
-
-
Oishi, S.1
Ito, S.2
Nishikawa, H.3
-
11
-
-
50049102385
-
Novel screening systems for HIV-1 fusion mediated by two extra-virion heptad repeats of gp41
-
Nishikawa H, Kodama E, Sakakibara A, et al. Novel screening systems for HIV-1 fusion mediated by two extra-virion heptad repeats of gp41. Antiviral Res 2008; 80:71-76.
-
(2008)
Antiviral Res
, vol.80
, pp. 71-76
-
-
Nishikawa, H.1
Kodama, E.2
Sakakibara, A.3
-
12
-
-
15744393651
-
Different from the HIV fusion inhibitor C34, the anti-HIV drug Fuzeon (T-20) inhibits HIV-1 entry by targeting multiple sites in gp41 and gp120
-
Liu S, Lu H, Niu J, Xu Y, Wu S, Jiang S. Different from the HIV fusion inhibitor C34, the anti-HIV drug Fuzeon (T-20) inhibits HIV-1 entry by targeting multiple sites in gp41 and gp120. J Biol Chem 2005; 280:11259-11273.
-
(2005)
J Biol Chem
, vol.280
, pp. 11259-11273
-
-
Liu, S.1
Lu, H.2
Niu, J.3
Xu, Y.4
Wu, S.5
Jiang, S.6
-
13
-
-
63649151400
-
Interactions of HIV-1 inhibitory peptide T20 with the gp41 N-HR coiled coil
-
Champagne K, Shishido A, Root MJ. Interactions of HIV-1 inhibitory peptide T20 with the gp41 N-HR coiled coil. J Biol Chem 2009; 284:3619-3627.
-
(2009)
J Biol Chem
, vol.284
, pp. 3619-3627
-
-
Champagne, K.1
Shishido, A.2
Root, M.J.3
-
14
-
-
0035846960
-
Mode of action of an antiviral peptide from HIV-1. Inhibition at a post-lipid mixing stage
-
Kliger Y, Gallo SA, Peisajovich SG, et al. Mode of action of an antiviral peptide from HIV-1. Inhibition at a post-lipid mixing stage. J Biol Chem 2001; 276:1391-1397.
-
(2001)
J Biol Chem
, vol.276
, pp. 1391-1397
-
-
Kliger, Y.1
Gallo, S.A.2
Peisajovich, S.G.3
-
15
-
-
33748684791
-
Specific mutations in HIV-1 gp41 are associated with immunological success in HIV-1-infected patients receiving enfuvirtide treatment
-
Aquaro S, D'Arrigo R, Svicher V, et al. Specific mutations in HIV-1 gp41 are associated with immunological success in HIV-1-infected patients receiving enfuvirtide treatment. J Antimicrob Chemother 2006; 58:714-722.
-
(2006)
J Antimicrob Chemother
, vol.58
, pp. 714-722
-
-
Aquaro, S.1
D'arrigo, R.2
Svicher, V.3
-
16
-
-
7644236011
-
Emergence of a drug-dependent human immunodefciency virus type 1 variant during therapy with the T20 fusion inhibitor
-
Baldwin CE, Sanders RW, Deng Y, et al. Emergence of a drug-dependent human immunodefciency virus type 1 variant during therapy with the T20 fusion inhibitor. J Virol 2004; 78:12428-12437.
-
(2004)
J Virol
, vol.78
, pp. 12428-12437
-
-
Baldwin, C.E.1
Sanders, R.W.2
Deng, Y.3
-
17
-
-
33750252336
-
Genetic evolution of gp41 reveals a highly exclusive relationship between codons 36, 38 and 43 in gp41 under long-term enfuvirtide-containing salvage regimen
-
Cabrera C, Marfl S, Garcia E, et al. Genetic evolution of gp41 reveals a highly exclusive relationship between codons 36, 38 and 43 in gp41 under long-term enfuvirtide-containing salvage regimen. AIDS 2006; 20:2075-2080.
-
(2006)
AIDS
, vol.20
, pp. 2075-2080
-
-
Cabrera, C.1
Marfl, S.2
Garcia, E.3
-
18
-
-
0036896463
-
env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors
-
Fikkert V, Cherepanov P, Van Laethem K, et al. env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors. Antimicrob Agents Chemother 2002; 46:3954-3962.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 3954-3962
-
-
Fikkert, V.1
Cherepanov, P.2
van Laethem, K.3
-
19
-
-
64149109197
-
Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20
-
Izumi K, Kodama E, Shimura K, et al. Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20. J Biol Chem 2009; 284:4914-4920.
-
(2009)
J Biol Chem
, vol.284
, pp. 4914-4920
-
-
Izumi, K.1
Kodama, E.2
Shimura, K.3
-
20
-
-
23244461464
-
Determinants of human immunodeficiency virus type 1 resistance to membrane-anchored gp41-derived peptides
-
Lohrengel S, Hermann F, Hagmann I, et al. Determinants of human immunodeficiency virus type 1 resistance to membrane-anchored gp41-derived peptides. J Virol 2005; 79:10237-10246.
-
(2005)
J Virol
, vol.79
, pp. 10237-10246
-
-
Lohrengel, S.1
Hermann, F.2
Hagmann, I.3
-
21
-
-
25144489604
-
Impact of human immunodeficiency virus type 1 gp41 amino acid substitutions selected during enfuvirtide treatment on gp41 binding and antiviral potency of enfuvirtide in vitro
-
Mink M, Mosier SM, Janumpalli S, et al. Impact of human immunodeficiency virus type 1 gp41 amino acid substitutions selected during enfuvirtide treatment on gp41 binding and antiviral potency of enfuvirtide in vitro. J Virol 2005; 79:12447-12454.
-
(2005)
J Virol
, vol.79
, pp. 12447-12454
-
-
Mink, M.1
Mosier, S.M.2
Janumpalli, S.3
-
22
-
-
60849084600
-
Enfuvirtide (T-20) resistance-related mutations in HIV type 1 subtypes B, C, and F isolates from Brazilian patients failing HAART
-
Oliveira AC, Martins AN, Pires AF, et al. Enfuvirtide (T-20) resistance-related mutations in HIV type 1 subtypes B, C, and F isolates from Brazilian patients failing HAART. AIDS Res Hum Retroviruses 2009; 25:193-198.
-
(2009)
AIDS Res Hum Retroviruses
, vol.25
, pp. 193-198
-
-
Oliveira, A.C.1
Martins, A.N.2
Pires, A.F.3
-
23
-
-
0036090585
-
Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy
-
Wei X, Decker JM, Liu H, et al. Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy. Antimicrob Agents Chemother 2002; 46:1896-1905.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 1896-1905
-
-
Wei, X.1
Decker, J.M.2
Liu, H.3
-
24
-
-
59649099932
-
Electrostatically constrained alpha-helical peptide inhibits replication of HIV-1 resistant to enfuvirtide
-
Nishikawa H, Nakamura S, Kodama E, et al. Electrostatically constrained alpha-helical peptide inhibits replication of HIV-1 resistant to enfuvirtide. Int J Biochem Cell Biol 2009; 41:891-899.
-
(2009)
Int J Biochem Cell Biol
, vol.41
, pp. 891-899
-
-
Nishikawa, H.1
Nakamura, S.2
Kodama, E.3
-
25
-
-
0030899871
-
Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection
-
Chackerian B, Long EM, Luciw PA, Overbaugh J. Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection. J Virol 1997; 71:3932-3939.
-
(1997)
J Virol
, vol.71
, pp. 3932-3939
-
-
Chackerian, B.1
Long, E.M.2
Luciw, P.A.3
Overbaugh, J.4
-
26
-
-
77954956891
-
Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat
-
Izumi K, Nakamura S, Nakano H, et al. Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat. Antiviral Res 2010; 87:179-186.
-
(2010)
Antiviral Res
, vol.87
, pp. 179-186
-
-
Izumi, K.1
Nakamura, S.2
Nakano, H.3
-
27
-
-
62949102876
-
SC29EK, a peptide fusion inhibitor with enhanced alpha-helicity, inhibits replication of human immunodeficiency virus type 1 mutants resistant to enfuvirtide
-
Naito T, Izumi K, Kodama E, et al. SC29EK, a peptide fusion inhibitor with enhanced alpha-helicity, inhibits replication of human immunodeficiency virus type 1 mutants resistant to enfuvirtide. Antimicrob Agents Chemother 2009; 53:1013-1018.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 1013-1018
-
-
Naito, T.1
Izumi, K.2
Kodama, E.3
-
28
-
-
11144236493
-
Mutations conferring resistance to human immunodeficiency virus type 1 fusion inhibitors are restricted by gp41 and Rev-responsive element functions
-
Nameki D, Kodama E, Ikeuchi M, et al. Mutations conferring resistance to human immunodeficiency virus type 1 fusion inhibitors are restricted by gp41 and Rev-responsive element functions. J Virol 2005; 79:764-770.
-
(2005)
J Virol
, vol.79
, pp. 764-770
-
-
Nameki, D.1
Kodama, E.2
Ikeuchi, M.3
-
29
-
-
78649842313
-
Resistance profiles of novel electrostatically constrained HIV-1 fusion inhibitors
-
Shimura K, Nameki D, Kajiwara K, et al. Resistance profiles of novel electrostatically constrained HIV-1 fusion inhibitors. J Biol Chem 2010; 285:39471-39480.
-
(2010)
J Biol Chem
, vol.285
, pp. 39471-39480
-
-
Shimura, K.1
Nameki, D.2
Kajiwara, K.3
-
30
-
-
69349103719
-
X-ray crystallographic study of an HIV-1 fusion inhibitor with the gp41 S138A substitution
-
Watabe T, Terakawa Y, Watanabe K, et al. X-ray crystallographic study of an HIV-1 fusion inhibitor with the gp41 S138A substitution. J Mol Biol 2009; 392:657-665.
-
(2009)
J Mol Biol
, vol.392
, pp. 657-665
-
-
Watabe, T.1
Terakawa, Y.2
Watanabe, K.3
-
31
-
-
0037119022
-
Remodeling of gp41-C34 peptide leads to highly effective inhibitors of the fusion of HIV-1 with target cells
-
Otaka A, Nakamura M, Nameki D, et al. Remodeling of gp41-C34 peptide leads to highly effective inhibitors of the fusion of HIV-1 with target cells. Angew Chem Int Ed Engl 2002; 41:2937-2940.
-
(2002)
Angew Chem Int Ed Engl
, vol.41
, pp. 2937-2940
-
-
Otaka, A.1
Nakamura, M.2
Nameki, D.3
-
32
-
-
24644449058
-
Covalent stabilization of coiled coils of the HIV gp41 N region yields extremely potent and broad inhibitors of viral infection
-
Bianchi E, Finotto M, Ingallinella P, et al. Covalent stabilization of coiled coils of the HIV gp41 N region yields extremely potent and broad inhibitors of viral infection. Proc Natl Acad Sci U S A 2005; 102:12903-12908.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 12903-12908
-
-
Bianchi, E.1
Finotto, M.2
Ingallinella, P.3
-
33
-
-
0038187684
-
Novel therapies based on mechanisms of HIV-1 cell entry
-
Kilby JM, Eron JJ. Novel therapies based on mechanisms of HIV-1 cell entry. N Engl J Med 2003; 348:2228-2238.
-
(2003)
N Engl J Med
, vol.348
, pp. 2228-2238
-
-
Kilby, J.M.1
Eron, J.J.2
|