Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures

Brain Research

Volumn 1435, Issue , 2012, Pages 154-166

  Ishida, Saeko ^a   Sakamoto, Yu ^a   Nishio, Takeshi ^a   Baulac, Stéphanie ^a,b,c   Kuwamura, Mitsuru ^d   Ohno, Yukihiro ^e   Takizawa, Akiko ^a   Kaneko, Shuji ^a   Serikawa, Tadao ^a   Mashimo, Tomoji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b INSERM   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d Osaka Prefecture University   (Japan)

^e OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Animal model; Dominant negative effect; Episodic ataxia type 1 (EA1); Phenotype driven ENU mutagenesis; Voltage gated potassium channel shaker related subfamily member 1 (Kcna1); Voltage sensor domain S4

Indexed keywords

CARBAMAZEPINE; ETHYLNITROSOUREA; POTASSIUM CHANNEL KV1.1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATAXIA; AUTOSOMAL DOMINANT DISORDER; AUTOSOMAL DOMINANT MYOKYMIA AND SEIZURE; CELL MEMBRANE; COLD STRESS; CONTROLLED STUDY; DRUG SCREENING; EPISODIC ATAXIA TYPE 1; FEMALE; MALE; MISSENSE MUTATION; MOTOR DYSFUNCTION; MUTAGENESIS; MUTANT; MYOKYMIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RAT; SEIZURE; TONIC CLONIC SEIZURE; TREMOR; XENOPUS;

ANIMALS; ANTIEMETICS; BIOPHYSICAL PROCESSES; BIOTINYLATION; BODY WEIGHT; CARBAMAZEPINE; CELLS, CULTURED; CHROMOSOME MAPPING; DISEASE MODELS, ANIMAL; DNA MUTATIONAL ANALYSIS; ELECTRIC STIMULATION; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; EPILEPSY; ETHYLNITROSOUREA; GENE TRANSFER TECHNIQUES; HUMANS; ISAACS SYNDROME; KV1.1 POTASSIUM CHANNEL; MALE; MEMBRANE POTENTIALS; MICE; MODELS, MOLECULAR; MUTAGENESIS; MUTAGENS; MUTATION, MISSENSE; MYOKYMIA; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN TRANSPORT; PSYCHOMOTOR PERFORMANCE; RATS; RATS, INBRED F344; RATS, MUTANT STRAINS; SEQUENCE ANALYSIS; SERINE; SURVIVAL ANALYSIS; SWIMMING; THREONINE; TIME FACTORS; XENOPUS;

ANIMALIA; MUS; RATTUS;

EID: 84856393288     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.11.023     Document Type: Article

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