Effects of nasal immunization of multi-target preventive vaccines on atherosclerosis

Vaccine

Volumn 30, Issue 6, 2012, Pages 1029-1037

  Jun, Long ^a   Jie, Lin ^b   Dongping, Yuan ^a   Xin, Yang ^c   Taiming, Li ^c   Rongyue, Cao ^c   Jie, Wu ^c   Jingjing, Liu ^c  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b YUNNAN UNIVERSITY   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti inflammation; Atherosclerosis; Cholesteryl ester transfer protein; Heat shock protein 65; Lipid regulating

Indexed keywords

CHOLESTEROL ESTER TRANSFER PROTEIN; GAMMA INTERFERON; HEAT SHOCK PROTEIN 65; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 10; LIPOPROTEIN;

ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL DIET; DRUG DESIGN; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; LUNG LAVAGE; MALE; NASAL LAVAGE; NONHUMAN; NOSE CAVITY; PRIORITY JOURNAL; RABBIT;

ADMINISTRATION, INTRANASAL; ANIMALS; AORTA; ATHEROSCLEROSIS; CHOLESTEROL ESTER TRANSFER PROTEINS; DIET; DISEASE MODELS, ANIMAL; HEAT-SHOCK PROTEINS; IMMUNIZATION; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; LUNG; MALE; NASAL MUCOSA; RABBITS; VACCINES;

EID: 84856363976     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.12.043     Document Type: Article

References (41)

1. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999, 340(2):115-126. [PubMed: 9887164].
2. Libby P., Ridker P.M., Maseri A. Inflammation and atherosclerosis. Circulation 2002, 105(9):1135-1143. [PubMed: 11877368].
3. Tall A.R. Plasma lipid transfer proteins. J Lipid Res 1986, 27(4):361-367. [PubMed: 3522782].
4. Tabas I., Weiland D.A., Tall A.R. Unmodified low density lipoprotein causes cholesteryl ester accumulation in J774 macrophages. Proc Natl Acad Sci USA 1985, 82(2):416-420. [PubMed: 3855559].
5. Gaofu Q., Jun L., Xin Y., Wentao L., Jie W., Xiuyun Z., et al. Vaccinating rabbits with a cholesteryl ester transfer protein (CETP) B-cell epitope carried by heat shock protein-65 (Hsp65) for inducing anti-CETP antibodies and reducing aortic lesions in vivo. J Cardiovasc Pharmacol 2005, 45(6):591-598. [PubMed: 15897787].
6. Xiong Q., Li J., Jin L., Liu J., Li T. Nasal immunization with heat shock protein 65 attenuates atherosclerosis and reduces serum lipids in cholesterol-fed wild-type rabbits probably through different mechanisms. Immunol Lett 2009, 125(1):40-45. [PubMed: 19505506].
7. Maron R., Sukhova G., Faria A.M., Hoffmann E., Mach F., Libby P., et al. Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation 2002, 106(13):1708-1715. [PubMed: 12270867].
8. Harats D., Yacov N., Gilburd B., Shoenfeld Y., George J. Oral tolerance with heat shock protein 65 attenuates Mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions. J Am Coll Cardiol 2002, 40(7):1333-1338. [PubMed: 12383583].
9. Gaofu Q., Dan M., Jie W., Liao Z., Li Z., Roque R.S., et al. Long-lasting specific antibodies against CETP induced by subcutaneous and mucosal administration of a 26-amino acid CETP epitope carried by heat shock protein 65kDa in the absence of adjuvants. Vaccine 2004, 22(23-24):3187-3194. [PubMed: 15297073].
10. Lobo C.A., Dhar R., Kumar N. Immunization of mice with DNA-based Pfs25 elicits potent malaria transmission-blocking antibodies. Infect Immun 1999, 67(4):1688-1693. [PubMed: 10085005].
11. Pullen G.R., Fitzgerald M.G., Hosking C.S. Antibody avidity determination by ELISA using thiocyanate elution. J Immunol Methods 1986, 86(1):83-87. [PubMed: 3944471].
12. Gaofu Q., Jun L., Xiuyun Z., Wentao L., Jie W., Jingjing L. Antibody against cholesteryl ester transfer protein (CETP) elicited by a recombinant chimeric enzyme vaccine attenuated atherosclerosis in a rabbit model. Life Sci 2005, 77(21):2690-2702. [PubMed: 15963532].
13. Xu Q., Dietrich H., Steiner H.J., Gown A.M., Schoel B., Mikuz G., et al. Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65. Arterioscler Thromb 1992, 12(7):789-799. [PubMed: 1616904].
14. Xu Q., Willeit J., Marosi M., Kleindienst R., Oberhollenzer F., Kiechl S., et al. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis. Lancet 1993, 341(8840):255-259. [PubMed: 8093914].
15. Xu Q., Kiechl S., Mayr M., Metzler B., Egger G., Oberhollenzer F., et al. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis: clinical significance determined in a follow-up study. Circulation 1999, 100(11):1169-1174. [PubMed: 10484536].
16. George J., Shoenfeld Y., Afek A., Gilburd B., Keren P., Shaish A., et al. Enhanced fatty streak formation in C57BL/6J mice by immunization with heat shock protein-65. Arterioscler Thromb Vasc Biol 1999, 19(3):505-510. [PubMed: 10073950].
17. Afek A., George J., Gilburd B., Rauova L., Goldberg I., Kopolovic J., et al. Immunization of low-density lipoprotein receptor deficient (LDL-RD) mice with heat shock protein 65 (HSP-65) promotes early atherosclerosis. J Autoimmun 2000, 14(2):115-121. [PubMed: 10677242].
18. Tall A.R. Plasma cholesteryl ester transfer protein. J Lipid Res 1993, 34(8):1255-1274. [PubMed: 8409761].
19. Plump A.S., Masucci-Magoulas L., Bruce C., Bisgaier C.L., Breslow J.L., Tall A.R. Increased atherosclerosis in ApoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression. Arterioscler Thromb Vasc Biol 1999, 19(4):1105-1110. [PubMed: 10195942].
20. Sugano M., Makino N., Sawada S., Otsuka S., Watanabe M., Okamoto H., et al. Effect of antisense oligonucleotides against cholesteryl ester transfer protein on the development of atherosclerosis in cholesterol-fed rabbits. J Biol Chem 1998, 273(9):5033-5036. [PubMed: 9478952].
21. Whitlock M.E., Swenson T.L., Ramakrishnan R., Leonard M.T., Marcel Y.L., Milne R.W., et al. Monoclonal antibody inhibition of cholesteryl ester transfer protein activity in the rabbit. Effects on lipoprotein composition and high density lipoprotein cholesteryl ester metabolism. J Clin Invest 1989, 84(1):129-137. [PubMed: 2738149].
22. Rittershaus C.W., Miller D.P., Thomas L.J., Picard M.D., Honan C.M., Emmett C.D., et al. Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis. Arterioscler Thromb Vasc Biol 2000, 20(9):2106-2112. [PubMed: 10978256].
23. Morimoto R.I., Santoro M.G. Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection. Nat Biotechnol 1998, 16(9):833-838. [PubMed: 9743115].
24. Kaufmann S.H. Heat shock proteins and the immune response. Immunol Today 1990, 11(4):129-136. [PubMed: 2187470].
25. Wick G., Schett G., Amberger A., Kleindienst R., Xu Q. Is atherosclerosis an immunologically mediated disease?. Immunol Today 1995, 16(1):27-33. [PubMed: 7880386].
26. Salonen J.T., Ylä-Herttuala S., Yamamoto R., Butler S., Korpela H., Salonen R., et al. Autoantibody against oxidised LDL and progression of carotid atherosclerosis. Lancet 1992, 339(8798):883-887. [PubMed: 1348295].
27. Shoenfeld Y., Harats D., George J. Atherosclerosis and the antiphospholipid syndrome: a link unravelled?. Lupus 1998, 7(Suppl. 2):S140-S143. [PubMed: 9814692].
28. George J., Afek A., Gilburd B., Blank M., Levy Y., Aron-Maor A., et al. Induction of early atherosclerosis in LDL-receptor-deficient mice immunized with beta2-glycoprotein I. Circulation 1998, 98(11):1108-1115. [PubMed: 9736598].
29. Yi H., Rong Y., Yankai Z., Wentao L., Hongxia Z., Jie W., et al. Improved efficacy of DNA vaccination against breast cancer by boosting with the repeat beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65. Vaccine 2006, 24(14):2575-2584. [PubMed: 16420967].
30. Mann C.J., Yen F.T., Grant A.M., Bihain B.E. Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia. J Clin Invest 1991, 88(6):2059-2066. [PubMed: 1752964].
31. Genest J., Marcil M., Denis M., Yu L. High density lipoproteins in health and in disease. J Investig Med 1999, 47(1):31-42. [PubMed: 10071479].
32. Inazu A., Koizumi J., Mabuchi H. Cholesteryl ester transfer protein and atherosclerosis. Curr Opin Lipidol 2000, 11(4):389-396. [PubMed: 10945721].
33. Okamoto H., Yonemori F., Wakitani K., Minowa T., Maeda K., Shinkai H. A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits. Nature 2000, 406(6792):203-207. [PubMed: 10910363].
34. George J., Afek A., Gilburd B., Shoenfeld Y., Harats D. Cellular and humoral immune responses to heat shock protein 65 are both involved in promoting fatty-streak formation in LDL-deficient mice. J Am Coll Cardiol 2001, 38(3):900-905. [PubMed: 11527651].
35. Mayr M., Metzler B., Kiechl S., Willeit J., Schett G., Xu Q., et al. Endothelial cytotoxicity mediated by serum antibodies to heat shock proteins of Escherichia coli and Chlamydia pneumoniae: immune reactions to heat shock proteins as possible link between infection and atherosclerosis. Circulation 1999, 99(12):1560-1566. [PubMed: 10096931].
36. Gupta S., Pablo A.M., Jiang X., Wang N., Tall A.R., Schindler C. IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. J Clin Invest 1997, 99(11):2752-2761. [PubMed: 9169506].
37. Weiner H.L., da Cunha A.P., Quintana F., Wu H. Oral tolerance. Immunol Rev 2011, 241(1):241-259. [PubMed: 21488901].
38. Friedman A., Weiner H.L. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc Natl Acad Sci USA 1994, 91(14):6688-6692. [PubMed: 8022835].
39. Xu Q., Kleindienst R., Schett G., Waitz W., Jindal S., Gupta R.S., et al. Regression of atherosclerotic lesions induced by immunization with HSP-65-containing material in normocholesterolemic, but not hypercholesterolemic rabbits. Atherosclerosis 1996, 123(1-2):145-155. [PubMed: 8782846].
40. Ogra P.L., Faden H., Welliver R.C. Vaccination strategies for mucosal immune responses. Clin Microbiol Rev 2001, 14(2):430-445. [PubMed: 11292646].
41. Da Silva D.M., Schiller J.T., Kast W.M. Heterologous boosting increases immunogenicity of chimeric papillomavirus virus-like particle vaccines. Vaccine 2003, 21(23):3219-3227. [PubMed: 12804851].