You may need the vagus nerve to understand pathophysiology and to treat diseases

Clinical Science

Volumn 122, Issue 7, 2012, Pages 323-328

  De Couck, Marijke ^a   Mravec, Boris ^b,c   Gidron, Yori ^a  

^a FACULTY OF MEDICINE AND PHARMACY   (Belgium)

^b Faculty of Medicine of Comenius University and University Hospital Bratislava   (Slovakia)

^c INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

Author keywords

Alzheimer's disease; Cancer; Cardiovascular disease; Heart rate variability; Neuromodulation; Vagus nerve

Indexed keywords

C REACTIVE PROTEIN; CHOLINERGIC RECEPTOR STIMULATING AGENT; INTERLEUKIN 1; PROSTATE SPECIFIC ANTIGEN; PROTEIN P53;

ADRENERGIC SYSTEM; ALZHEIMER DISEASE; ARTICLE; CANCER STAGING; CARDIOVASCULAR DISEASE; CELL PROLIFERATION; DIABETES MELLITUS; DNA DAMAGE; DNA FRAGMENTATION; DYSLIPIDEMIA; ELECTROCARDIOGRAM; HEART RATE VARIABILITY; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INFLAMMATION; METABOLIC SYNDROME X; NEOPLASM; NEUROTRANSMISSION; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROGNOSIS; PROSTATE CANCER; PROTEIN EXPRESSION; RISK FACTOR; RISK REDUCTION; VAGUS NERVE; VAGUS NERVE STIMULATION; BIOLOGICAL MODEL; DISEASES; PHYSIOLOGY;

DISEASE; HUMANS; MODELS, BIOLOGICAL; PROGNOSIS; RISK FACTORS; SYMPATHETIC NERVOUS SYSTEM; VAGUS NERVE;

EID: 84856363183     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20110299     Document Type: Article

References (47)

1. Mathers, C. D., Boerma, T. and Ma Fat, D. (2009) Global and regional causes of death. Br. Med. Bull. 92, 7-32
2. World Health Organization (2003) World Health Report 2003: Shaping the Future, WHO, Geneva
3. Johansen, D., Stocks, T., Jonsson, H., Lindkvist, B., Björge, T., Concin, H., Almquist, M., Häggström, C., Engeland, A., Ulmer, H. et al. (2010) Metabolic factors and the risk of pancreatic cancer: a prospective analysis of almost 580,000 men and women in the Metabolic Syndrome and Cancer Project. Cancer Epidemiol. Biomarkers Prev. 9, 2307-2317
4. Arnlöv, J., Ingelsson, E., Sundström, J. and Lind, L. (2010) Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men. Circulation 121, 230-236
5. Tarride, J. E., Lim, M., DesMeules, M., Luo, W., Burke, N., O'Reilly, D., Bowen, J. and Goeree, R. (2009) A review of the cost of cardiovascular disease. Can. J. Cardiol. 25, 195-202
6. Nagayoshi, Y., Kawano, H., Hokamaki, J., Miyamoto, S., Kojima, S., Shimomura, H., Tsujita, K., Sakamoto, T., Yoshimura, M. and Ogawa, H. (2005) Urinary 8-hydroxy-2'-deoxyguanosine levels increase after reperfusion in acute myocardial infarction and may predict subsequent cardiac events. Am. J. Cardiol. 95, 514-517
7. Westhuyzen, J. (1997) The oxidation hypothesis of atherosclerosis: an update. Ann. Clin. Lab. Sci. 27, 1-10
8. Valko, M., Izakovic, M., Mazur, M., Rhodes, C. J. and Telser, J. (2004) Role of oxygen radicals in DNA damage and cancer incidence. Mol. Cell. Biochem. 266, 37-56
9. Cherubini, A., Ruggiero, C., Polidori, M. C. and Mecocci, P. (2005) Potential markers of oxidative stress in stroke. Free Radical Biol Med. 39, 841-852
10. Kruman, I., Bruce-Keller, A. J., Bredesen, D.,Waeg, G. and Mattson, M. P. (1997) Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J. Neurosci. 17, 5089-5100
11. Ross, R. (1999) Atherosclerosis: an inflammatory disease. N. Engl. J. Med. 340, 115-126
12. Voronov, E., Shouval, D. S., Krelin, Y., Cagnano, E., Benharroch, D., Iwakura, Y., Dinarello, C. A. and Apte, R. (2003) IL-1 is required for tumor invasiveness and angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 100, 2645-2650
13. Mantovani, A., Allavena, P., Sica, A. and Balkwill, F. (2008) Cancer-related inflammation. Nature 454, 436-444
14. Aisen, PS. (2005) The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease. Lancet Neurol. 1, 279-284
15. Remme, W. J. (1998) The sympathetic nervous system and ischaemic heart disease. Eur. Heart J. 19, F62-F71
16. Entschladen, F., Drell, IV, T.L., Lang, K., Joseph, J. and Zaenker, K. S. (2004) Tumour-cell migration, invasion, and metastasis: navigation by neurotransmitters. Lancet Oncol. 5, 254-258
17. Van Beek, A. H. and Claassen, J. A. (2010) The cerebrovascular role of the cholinergic neural system in Alzheimer's disease. Behav. Brain Res. 221, 537-542
18. Goodarzi, M. T., Navidi, A. A., Rezaei, M. and Babahmadi-Rezaei, H. (2010) Oxidative damage to DNA and lipids: correlation with protein glycation in patients with type 1 diabetes. J. Clin. Lab. Anal. 24, 72-76
19. Dzau, V. J., Antman, E. M., Black, H. R., Hayes, D. L., Manson, J. E., Plutzky, J., Popma, J. J. and Stevenson, W. (2006) The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part I: Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease). Circulation 114, 2850-2870
20. Ridker, P. M., Buring, J. E., Cook, N. R. and Rifai, N. (2003) C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation 107, 391-397
21. Reference deleted
22. La Rovere, M. T., Bigger, Jr, J. T., Marcus, F. I., Mortara, A. and Schwartz, P. J. (1998) Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. Lancet 351, 478-484
23. He, L., Li, C., Luo, Y., Dong, W. and Yang, H. (2009) Clinical prognostic significance of heart abnormality and heart rate variability in patients with stroke. Neurol. Res. 32, 530-534
24. Chiang, J. K., Koo, M., Kuo, T. B. and Fu, C. H. (2010) Association between cardiovascular autonomic functions and time to death in patients with terminal hepatocellular carcinoma. J. Pain Symptom Manage. 39, 673-679
25. Toledo, M. A. and Junqueira, Jr, L. F. (2010) Cardiac autonomic modulation and cognitive status in Alzheimer's disease. Clin. Auton. Res. 20, 11-17
26. Licht, C. M., Vreeburg, S. A., van Reedt Dortland, A. K., Giltay, E. J., Hoogendijk, W. J., DeRijk, R. H., Vogelzangs, N., Zitman, F. G., de Geus, E. J. and Penninx, B. W. (2010) Increased sympathetic and decreased parasympathetic activity rather than changes in hypothalamic-pituitary-adrenal axis activity is associated with metabolic abnormalities. J. Clin. Endocrinol. Metab. 95, 2458-2466
27. Ek, M., Kurosawa, M., Lundeberg, T. and Ericsson, A. (1998) Activation of vagal afferents after intravenous injection of interleukin-1β: role of endogenous prostaglandins. J. Neurosci. 18, 9471-9479
28. Tsutsumi, T., Ide, T., Yamato, M., Kudou, W., Andou, M., Hirooka, Y., Utsumi, H., Tsutsui, H. and Sunagawa, K. (2008) Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction. Cardiovasc. Res. 77, 713-721
29. Ottani, A., Giuliani, D., Mioni, C., Galantucci, M., Minutoli, L., Bitto, A., Altavilla, D., Zaffe, D., Botticelli, A. R., Squadrito, F. and Guarini, S. (2009) Vagus nerve mediates the protective effects of melanocortins against cerebral and systemic damage after ischemic stroke. J. Cereb. Blood Flow Metab. 29, 512-523
30. Loreti, S., Ricordy, R., Egle De Stefano, M., Augusti-Tocco, G. and Maria Tata, A. (2007) Acetylcholine inhibits cell cycle progression in rat Schwann cells by activation of the M2 receptor subtype. Neuron Glia Biol. 3, 269-279
31. Zhao, Y., Wang, X., Wang, T., Hu, X., Hui, X., Yan, M., Gao, Q., Chen, T., Li, J., Yao, M. et al. (2011) Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization. Hepatology 53, 493-503
32. Tracey, K. J. (2009) Reflex control of immunity. Nat Rev Immunol. 9, 418-428
33. Janszky, I., Ericson, M., Lekander, M., Blom, M., Buhlin, K., Georgiades, A. and Ahnve, S. (2004) Inflammatory markers and heart rate variability in women with coronary heart disease. J. Intern. Med. 256, 421-428
34. Lee, S. T., Chu, K., Jung, K. H., Kang, K. M., Kim, J. H., Bahn, J. J., Jeon, D., Kim, M., Lee, S. K. and Roh, J. K. (2010) Cholinergic anti-inflammatory pathway in intracerebral hemorrhage. Brain Res. 1309, 164-171
35. Vlcek, M., Radikova, Z., Penesova, A., Kvetnansky, R. and Imrich, R. (2008) Heart rate variability and catecholamines during hypoglycemia and orthostasis. Auton. Neurosci. 143, 53-57
36. 2+ channel antagonists on nerve stimulation-induced and ischemia-induced myocardial interstitial acetylcholine release in cats. Am. J. Physiol. Heart Circ. Physiol. 291, H2187-H2191
37. Sajadieh, A., Nielsen, O. W., Rasmussen, V., Hein, H. O. and Hansen, J. F. (2006) C-reactive protein, heart rate variability and prognosis in community subjects with no apparent heart disease. J. Intern. Med. 260, 377-387
38. Downing, J. E. G. and Miyan, J. A. (2000) Neural immunoregulation: emerging roles for nerves in immune homeostasis and disease. Immunol. Today 21, 281-289
39. Kupper, N. H., Willemsen, G., van den Berg, M., de Boer, D., Posthuma, D., Boomsma, D. I. and de Geus, E. J. (2004) Heritability of ambulatory heart rate variability. Circulation 110, 2792-2796
40. Erin, N., Akdas Barkan, G., Harms, J. F. and Clawson, G. A. (2008) Vagotomy enhances experimental metastases of 4THMpc breast cancer cells and alters substance P level. Regul. Pept. 151, 35-42
41. Ozgocmen, S., Ozyurt, H., Sogut, S. and Akyol, O. (2006) Current concepts in the pathophysiology of fibromyalgia: the potential role of oxidative stress and nitric oxide. Rheumatol. Int. 26, 585-597
42. Tal, M. (1999) A role for inflammation in chronic pain. Curr. Rev. Pain 3, 440-446
43. Schlereth, T. and Birklein, F. (2008) The sympathetic nervous system and pain. Neuromolecular Med. 10, 141-147
44. Tan, G., Fink, B., Dao, T. K., Hebert, R., Farmer, L. S., Sanders, A., Pastorek, N. and Gevirtz, R. (2009) Associations among pain, PTSD, mTBI, and heart rate variability in veterans of Operation Enduring and Iraqi Freedom: a pilot study. Pain Med. 10, 1237-1245
45. Kraus, T., Hösl, K., Kiess, O., Schanze, A., Kornhuber, J. and Forster, C. (2007) BOLD fMRI deactivation of limbic and temporal brain structures and mood enhancing effect by transcutaneous vagus nerve stimulation. J. Neural Transm. 114, 1485-1493
46. Kuo, T. B., Lai, C. J., Huang, Y. T. and Yang, C. C. (2005) Regression analysis between heart rate variability and baroreflex-related vagus nerve activity in rats. J. Cardiovasc. Electrophysiol. 16, 864-869
47. Gidron, Y., Perry, H. and Glennie, M. (2005) The vagus may inform the brain about sub-clinical tumors and modulate them: an Hypothesis. Lancet Oncol. 6, 245-248