The cerebrovascular role of the cholinergic neural system in Alzheimer's disease

Behavioural Brain Research

Volumn 221, Issue 2, 2011, Pages 537-542

  Van Beek, Arenda H E A ^a   Claassen, Jurgen A H R ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Alzheimer's disease; Basal forebrain; Cerebrovascular circulation; Cholinergic nerves; Cholinesterase inhibitors

Indexed keywords

BUNGAROTOXIN RECEPTOR;

ALZHEIMER DISEASE; ATTENTION; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; BRAIN BLOOD FLOW; BRAIN CIRCULATION; BRAIN CIRCULUS ARTERIOSUS; BRAIN FUNCTION; CHOLINERGIC SYSTEM; CHOLINERGIC TRANSMISSION; COGNITION; HUMAN; MEYNERT BASAL NUCLEUS; MOLECULAR DYNAMICS; NEUROIMAGING; NONHUMAN; OXYGENATION; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SUBARACHNOID SPACE; SYMPATHETIC NERVE;

ALZHEIMER DISEASE; ANIMALS; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; CHOLINERGIC FIBERS; CHOLINESTERASE INHIBITORS; HOMEOSTASIS; HUMANS; MODELS, NEUROLOGICAL;

EID: 79955735314     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2009.12.047     Document Type: Review

References (50)

1. Francis P.T., Palmer A.M., Snape M., Wilcock G.K. The cholinergic hypothesis of Alzheimer's disease: a review of progress. J Neurol Neurosurg Psychiatry 1999, 66:137-147.
2. Hamel E. Perivascular nerves and the regulation of cerebrovascular tone. J Appl Physiol 2006, 100:1059-1064.
3. Tong X.K., Hamel E. Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease. Neuroscience 1999, 92:163-175.
4. Iadecola C. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci 2004, 5:347-360.
5. Zlokovic B.V. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci 2005, 28:202-208.
6. Claassen J.A., van Beek A.H., Olde Rikkert M.G. Short review: acetylcholinesterase-inhibitors in Alzheimer's disease have opposing effects on blood pressure and cerebral perfusion. J Nutr Health Aging 2009, 13:231-233.
7. Claassen J.A., Jansen R.W. Cholinergically mediated augmentation of cerebral perfusion in Alzheimer's disease and related cognitive disorders: the cholinergic-vascular hypothesis. J Gerontol A Biol Sci Med Sci 2006, 61:267-271.
8. Edvinsson L., Hamel E. Perivascular nerves in brain vessels. Cerebral blood flow and metabolism 2002, 395-412. Lippincott Williams & Wilkins, Philadelphia. Lars Edvinsson, D.N. Krause (Eds.).
9. Vaucher E., Hamel E. Cholinergic basal forebrain neurons project to cortical microvessels in the rat: electron microscopic study with anterogradely transported Phaseolus vulgaris leucoagglutinin and choline acetyltransferase immunocytochemistry. J Neurosci 1995, 15:7427-7441.
10. Sato A., Sato Y. Cholinergic neural regulation of regional cerebral blood flow. Alzheimer's Dis Assoc Disord 1995, 9:28-38.
11. Hamel E. Cholinergic modulation of the cortical microvascular bed. Prog Brain Res 2004, 145:171-178.
12. Gulbenkian S., Uddman R., Edvinsson L. Neuronal messengers in the human cerebral circulation. Peptides 2001, 22:995-1007.
13. Van Lieshout J.J., Wieling W., Karemaker J.M., Secher N.H. Syncope, cerebral perfusion, and oxygenation. J Appl Physiol 2003, 94:833-848.
14. Si M.L., Lee T.J. Alpha7-nicotinic acetylcholine receptors on cerebral perivascular sympathetic nerves mediate choline-induced nitrergic neurogenic vasodilation. Circ Res 2002, 91:62-69.
15. Girouard H., Iadecola C. Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer's disease. J Appl Physiol 2006, 100:328-335.
16. Blennow K., de Leon M.J., Zetterberg H. Alzheimer's disease. Lancet 2006, 368:387-403.
17. Iadecola C., Park L., Capone C. Threats to the mind: aging, amyloid, and hypertension. Stroke 2009, 40:S40-S44.
18. Viswanathan A, Rocca W.A., Tzourio C. Vascular risk factors and dementia: how to move forward?. Neurology 2009, 72:368-374.
19. de la Torre J.C. Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics. Lancet Neurol 2004, 3:184-190.
20. Terry A.V., Buccafusco J.J The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development. J Pharmacol Exp Ther 2003, 306:821-827.
21. Aarsland D., Mosimann U.P., McKeith I.G. Role of cholinesterase inhibitors in Parkinson's disease and dementia with Lewy bodies. J Geriatr Psychiatry Neurol 2004, 17:164-171.
22. Birks J. Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev 2006, CD005593.
23. Maidment I., Fox C., Boustani M. Cholinesterase inhibitors for Parkinson's disease dementia. Cochrane Database Syst Rev 2006, CD004747.
24. Malouf R., Birks J. Donepezil for vascular cognitive impairment. Cochrane Database Syst Rev 2004, CD004395.
25. Blin J., Ivanoiu A., Coppens A., De V.A., Labar D., Michel C., et al. Cholinergic neurotransmission has different effects on cerebral glucose consumption and blood flow in young normals, aged normals, and Alzheimer's disease patients. Neuroimage 1997, 6:335-343.
26. Honer W.G, Prohovnik I., Smith G., Lucas L.R. Scopolamine reduces frontal cortex perfusion. J Cereb Blood Flow Metab 1988, 8:635-641.
27. Hanyu H., Shimizu T., Tanaka Y., Takasaki M., Koizumi K., Abe K. Regional cerebral blood flow patterns and response to donepezil treatment in patients with Alzheimer's disease. Dement Geriatr Cogn Disord 2003, 15:177-182.
28. Lojkowska W., Ryglewicz D., Jedrzejczak T., Minc S., Jakubowska T., Jarosz H., et al. The effect of cholinesterase inhibitors on the regional blood flow in patients with Alzheimer's disease and vascular dementia. J Neurol Sci 2003, 216:119-126.
29. Nakano S., Asada T., Matsuda H., Uno M., Takasaki M. Donepezil hydrochloride preserves regional cerebral blood flow in patients with Alzheimer's disease. J Nucl Med 2001, 42:1441-1445.
30. Nobili F., Vitali P., Canfora M., Girtler N., De L.C., Mariani G., et al. Effects of long-term Donepezil therapy on rCBF of Alzheimer's patients. Clin Neurophysiol 2002, 113:1241-1248.
31. Nobili F., Koulibaly M., Vitali P., Migneco O., Mariani G., Ebmeier K., et al. Brain perfusion follow-up in Alzheimer's patients during treatment with acetylcholinesterase inhibitors. J Nucl Med 2002, 43:983-990.
32. Rodriguez G., Vitali P., Canfora M., Calvini P., Girtler N., De L.C., et al. Quantitative EEG and perfusional single photon emission computed tomography correlation during long-term donepezil therapy in Alzheimer's disease. Clin Neurophysiol 2004, 115:39-49.
33. Staff R.T., Gemmell H.G., Shanks M.F., Murray A.D., Venneri A. Changes in the rCBF images of patients with Alzheimer's disease receiving Donepezil therapy. Nucl Med Commun 2000, 21:37-41.
34. Ceravolo R., Volterrani D., Tognoni G., Dell'Agnello G., Manca G., Kiferle L., et al. Cerebral perfusional effects of cholinesterase inhibitors in Alzheimer's disease. Clin Neuropharmacol 2004, 27:166-170.
35. Vennerica A., Shanks M.F., Staff R.T., Pestell S.J., Forbes K.E., Gemmell H.G., et al. Cerebral blood flow and cognitive responses to rivastigmine treatment in Alzheimer's disease. Neuroreport 2002, 13:83-87.
36. Scremin O.U., Rovere A.A., Raynald A.C., Giardini A. Cholinergic control of blood flow in the cerebral cortex of the rat. Stroke 1973, 4:233-239.
37. Lacombe P., Sercombe R., Vaucher E., Seylaz J. Reduced cortical vasodilatory response to stimulation of the nucleus basalis of Meynert in the aged rat and evidence for a control of the cerebral circulation. Ann N Y Acad Sci 1997, 826:410-415.
38. Vaucher E., Borredon J., Bonvento G., Seylaz J., Lacombe P. Autoradiographic evidence for flow-metabolism uncoupling during stimulation of the nucleus basalis of Meynert in the conscious rat. J Cereb Blood Flow Metab 1997, 17:686-694.
39. Nordberg A. PET studies and cholinergic therapy in Alzheimer's disease. Rev Neurol (Paris) 1999, 155(Suppl. 4):S53-S63.
40. Zhang R., Zuckerman J.H., Iwasaki K., Wilson T.E., Crandall C.G., Levine B.D. Autonomic neural control of dynamic cerebral autoregulation in humans. Circulation 2002, 106:1814-1820.
41. Claassen J.A., Zhang R., Fu Q., Witkowski S., Levine B.D. Transcranial Doppler estimation of cerebral blood flow and cerebrovascular conductance during modified rebreathing. J Appl Physiol 2007, 102:870-877.
42. Aaslid R., Markwalder T.M., Nornes H. Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 1982, 57:769-774.
43. van Beek A.H., Claassen J.A., Rikkert M.G., Jansen R.W. Cerebral autoregulation: an overview of current concepts and methodology with special focus on the elderly. J Cereb Blood Flow Metab 2008, 28:1071-1085.
44. Silvestrini M., Pasqualetti P., Baruffaldi R., Bartolini M., Handouk Y., Matteis M., et al. Cerebrovascular reactivity and cognitive decline in patients with Alzheimer disease. Stroke 2006, 37:1010-1015.
45. Rosengarten B., Paulsen S., Molnar S., Kaschel R., Gallhofer B., Kaps M. Acetylcholine esterase inhibitor donepezil improves dynamic cerebrovascular regulation in Alzheimer patients. J Neurol 2006, 253:58-64.
46. Bar K.J., Boettger M.K., Seidler N., Mentzel H.J., Terborg C., Sauer H. Influence of galantamine on vasomotor reactivity in Alzheimer's disease and vascular dementia due to cerebral microangiopathy. Stroke 2007, 38:3186-3192.
47. Rosengarten B., Paulsen S., Burr O., Kaps M. Neurovascular coupling in Alzheimer patients: effect of acetylcholine-esterase inhibitors. Neurobiol Aging 2008.
48. Claassen J.A., Diaz-Arrastia R., Martin-Cook K., Levine B.D., Zhang R. Altered cerebral hemodynamics in early Alzheimer disease: a pilot study using transcranial Doppler. J Alzheimer's Dis 2009.
49. Kim Y.S., Bogert L.W., Immink R.V., Harms M.P., Colier W.N., Van Lieshout J.J. Effects of aging on the cerebrovascular orthostatic response. Neurobiol Aging 2009.
50. van Beek A.H., Olde Rikkert M.G., Pasman J.W., Hopman M.T., Claassen J.A. Dynamic cerebral autoregulation in the old using a repeated sit-stand maneuver. Ultrasound Med Biol 2009, doi:101.1016/j.ultrasmedbio.2009.10.011.