Increased risk of sudden unexpected death in epilepsy in females using lamotrigine: A nested, case-control study

Epilepsia

Volumn 53, Issue 2, 2012, Pages 258-266

  Aurlien, Dag ^a   Larsen, Jan Petter ^a   Gjerstad, Leif ^b,c   Taubøll, Erik ^b,c  

^a STAVANGER UNIVERSITY HOSPITAL   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

Females; Lamotrigine; Sudden unexpected death in epilepsy

Indexed keywords

CARBAMAZEPINE; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; TOPIRAMATE; VALPROIC ACID; VIGABATRIN;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; AUTOPSY; CASE CONTROL STUDY; CONTROLLED STUDY; EPILEPSY; FEMALE; GENDER; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NORWAY; PRIORITY JOURNAL; REGISTER; RISK; SUDDEN DEATH; SUDDEN UNEXPECTED DEATH IN EPILEPSY; VICTIM;

ADOLESCENT; ADULT; AGED; ANTICONVULSANTS; CASE-CONTROL STUDIES; DEATH, SUDDEN; EPILEPSY; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; RISK FACTORS; TRIAZINES; YOUNG ADULT;

EID: 84856362768     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2011.03334.x     Document Type: Article

References (33)

1. Alvarez A, Pahissa J,. (2010) QT alterations in psychopharmacology: proven candidates and suspects. Curr Drug Saf 5: 97-104.
2. Annegers JF, Coan SP,. (1999) SUDEP: overview of definitions and review of incidence data. Seizure 8: 347-352. (Pubitemid 29469324)
3. Aurlien D, Taubøll E, Gjerstad L,. (2007) Lamotrigine in idiopathic epilepsy-increased risk of cardiac death? Acta Neurol Scand 115: 199-203. (Pubitemid 46219214)
4. Aurlien D, Leren TP, Taubøll E, Gjerstad L,. (2009) New SCN5A mutation in a SUDEP victim with idiopathic epilepsy. Seizure 18: 158-160.
5. Brotherstone R, Blackhall B, McLellan A,. (2010) Lengthening of corrected QT during epileptic seizures. Epilepsia 51: 221-232.
6. Danielsson BR, Lansdell K, Patmore L, Tomson T,. (2005) Effects of the antiepileptic drugs lamotrigine, topiramate and gabapentin on hERG potassium currents. Epilepsy Res 63: 17-25. (Pubitemid 40220335)
7. Dixon R, Job S, Oliver R, Tompson D, Wright JG, Maltby K, Lorch U, Taubel J,. (2008) Lamotrigine does not prolong QTc in a thorough QT/QTc study in healthy subjects. Br J Clin Pharmacol 66: 396-404.
8. Forsgren L,. (2004) Epidemiology and prognosis of epilepsy and its treatment. In, Shorvon S, Perrucca E, Fish D, Dodson E, (Eds) The treatment of epilepsy. Blackwell Publishing, Oxford, UK, pp. 21-42.
9. Heron SE, Hernandez M, Edwards C, Edkins E, Jansen FE, Scheffer IE, Bercovic SF, Mulley JC,. (2010) Neonatal seizures and long QT syndrome: a cardiocerebral channelopathy? Epilepsia 51: 293-296.
10. Hesdorffer DC, Tomson T, Benn E, Sander JW, Nilsson L, Langan Y, Walczak TS, Beghi E, Brodie MJ, Hauser A,. (2011) Combined analysis of risk factors for SUDEP. Epilepsia 52: 1150-1159.
11. ILAE,. (1989) Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia 30: 389-399.
12. Langan Y, Nashef L, Sander JW,. (2005) Case-control study of SUDEP. Neurology 64: 1131-1133.
13. Leestma JE, Walczak T, Hughes JR, Kalelkar MB, Teas SS,. (1989) A prospective study on sudden unexpected death in epilepsy. Ann Neurol 26: 195-203. (Pubitemid 19193086)
14. Leestma JE, Annegers JF, Brodie M, Brown S, Schraeder P, Siscovick D, Wannamaker BB, Tennis PS, Cierpial MA, Earl NL,. (1997) Sudden unexplained death in epilepsy: observations from a large clinical development program. Epilepsia 38: 47-55. (Pubitemid 27057480)
15. Legros B, Boon P, De Jonghe P, Sadzot B, Van Rijckevorsel K, Schmedding E,. (2009) Opinion of Belgian neurologists on antiepileptic drug treatment in 2006: Belgian study on epilepsy treatment (BESET-2). Acta Neurol Scand 120: 402-410.
16. Lehmann MH, Hardy S, Archibald D, Macneil DJ,. (1999) JTc prolongation with d,l-sotalol in women versus men. Am J Cardiol 83: 354-359. (Pubitemid 29066493)
17. Lhatoo SD, Johnson AL, Goodridge DM, MacDonald BK, Sander JW, Shorvon SD,. (2001) Mortality in epilepsy in the first 11 to 14 years after diagnosis: multivariate analysis of a long-term, prospective, population-based cohort. Ann Neurol 49: 336-344. (Pubitemid 32202787)
18. Makkar RR, Fromm BS, Steinman RT, Meissner MD, Lehmann MH,. (1993) Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs. JAMA 270: 2590-2597. (Pubitemid 23346699)
19. Nashef L,. (1997) Sudden unexpected death in epilepsy: terminology and definitions. Epilepsia 38 (Suppl.): 6-8.
20. Nashef L, Hindocha N, Makoff A,. (2007) Risk factors in sudden death in epilepsy (SUDEP): the quest for mechanisms. Epilepsia 48: 859-871. (Pubitemid 46763417)
21. Nilsson L, Farahmand BY, Persson PG, Thiblin I, Tomson T,. (1999) Risk factors for sudden unexpected death in epilepsy: a case-control study. Lancet 353: 888-893. (Pubitemid 29126877)
22. Nilsson L, Bergman U, Diwan V, Farahmand BY, Persson PG, Tomson T,. (2001) Antiepileptic drug therapy and its management in sudden unexpected death in epilepsy: a case-control study. Epilepsia 42: 667-673. (Pubitemid 32453652)
23. Oteri A, Trifirò G, Gagliostro MS, Tari DU, Moretti S, Bramanti P, Spina E, Caputi AP, Arcoraci V,. (2010) Prescribing pattern of anti-epileptic drugs in an Italian setting of elderly outpatients: a population-based study during 2004-07. Br J Clin Pharmacol 70: 514-522.
24. Rambeck B, Wolf P,. (1993) Lamotrigine clinical pharmacokinetics. Clin Pharmacokinet 25: 433-443. (Pubitemid 23358031)
25. Redfern WS, Carlsson L, Davis AS, Lynch WG, MacKenzie I, Palethorpe S, Siegl PK, Sullivan AT, Wallis R, Camm AJ, Hammond TG,. (2003) Relationship between preclinical electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc Res 58: 32-45. (Pubitemid 36351620)
26. Surges R, Thijs RD, Tan HL, Sander JW,. (2009) Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms. Nat Rev Neurol 5: 492-504.
27. Timmings PL,. (1998) Sudden unexpected death in epilepsy: is carbamazepine implicated? Seizure 7: 289-291. (Pubitemid 28421032)
28. Tomson T, Skold AC, Holmgren P, Nilsson L, Danielsson B,. (1998) Post mortem changes in blood concentrations of phenytoin and carbamazepine: an experimental study. Ther Drug Monit 20: 309-312. (Pubitemid 28248851)
29. Tomson T, Walczak T, Sillanpaa M, Sander JW,. (2005) Sudden unexpected death in epilepsy: a review of incidence and risk factors. Epilepsia 46 (Suppl. 11): 54-61. (Pubitemid 44922040)
30. Tomson T, Nashef L, Ryvlin P,. (2008) Sudden unexpected death in epilepsy: current knowledge and future directions. Lancet Neurol 7: 1021-1031.
31. Vereecke J, Carmeliet E,. (2000) The effect of external pH on the delayed rectifying K+ current in cardiac ventricular myocytes. Pflugers Arch 439: 739-751. (Pubitemid 30191148)
32. Walczak TS, Leppik IE, D'Amelio M, Rarick J, So E, Ahman P, Ruggles K, Cascino GD, Annegers JF, Hauser WA,. (2001) Incidence and risk factors in sudden unexpected death in epilepsy: a prospective cohort study. Neurology 56: 519-525. (Pubitemid 32172879)
33. Witchell HJ, Hancox JC,. (2000) Familial and acquired long QT syndrome and the cardiac rapid delayed rectifier potassium current. Clin Exp Pharmacol Physiol 27: 753-766.