Prescribing pattern of anti-epileptic drugs in an Italian setting of elderly outpatients: A population-based study during 2004-07

British Journal of Clinical Pharmacology

Volumn 70, Issue 4, 2010, Pages 514-522

  Oteri, Alessandro ^a   Trifirò, Gianluca ^a,b   Gagliostro, Maria Silvia ^a   Tari, Daniele Ugo ^c   Moretti, Salvatore ^c   Bramanti, Placido ^b   Spina, Edoardo ^a,b   Caputi, Achille Patrizio ^a,b   Arcoraci, Vincenzo ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

^c 'Caserta 1' Local Health Unit   (Italy)

Author keywords

antiepileptic drugs; elderly; epilepsy; general practitioners database; neuropathic pain

Indexed keywords

ANTICONVULSIVE AGENT; BARBEXACLONE; CARBAMAZEPINE; CLONAZEPAM; ETHOSUXIMIDE; ETIRACETAM; FELBAMATE; GABAPENTIN; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PREGABALIN; PRIMIDONE; TIAGABINE; TOPIRAMATE; VALPROIC ACID; VALPROMIDE; VIGABATRIN; ZONISAMIDE;

AGED; ARTICLE; BIPOLAR DISORDER; DRUG INDICATION; DRUG USE; DRUG UTILIZATION; EPILEPSY; FEMALE; GERIATRIC PATIENT; HEALTH CARE POLICY; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; MOOD DISORDER; NEUROPATHIC PAIN; OUTPATIENT; POPULATION RESEARCH; PRESCRIPTION; PRIORITY JOURNAL; REIMBURSEMENT;

AGED; ANTICONVULSANTS; DRUG PRESCRIPTIONS; EPILEPSY; FAMILY PRACTICE; HUMANS; INCIDENCE; ITALY; PHYSICIAN'S PRACTICE PATTERNS; PREVALENCE;

EID: 77956596621     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2010.03619.x     Document Type: Article

References (35)

1. Theodore WH, Fisher RS. Brain stimulation for epilepsy. Lancet Neurol 2004 3:111 118.
2. Engel J Jr., Wiebe S, French J, Sperling M, Williamson P, Spencer D, Gumnit R, Zahn C, Westbrook E, Enos B, Quality Standards Subcommittee of the American Academy of Neurology, American Epilepsy Society, American Association of Neurological Surgeons. Practice parameter: temporal lobe and localized neocortical resections for epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology, in association with the American Epilepsy Society and the American Association of Neurological Surgeons. Neurology 2003 60:538 547.
3. Tsiropoulos I, Gichangi A, Andersen M, Bjerrum L, Gaist D, Hallas J. Trends in utilization of antiepileptic drugs in Denmark. Acta Neurol Scand 2006 113:405 411. Erratum in: Acta Neurol Scand 2006; 114: 70.
4. Savica R, Beghi E, Mazzaglia G, Innocenti F, Brignoli O, Cricelli C, Caputi AP, Musolino R, Spina E, Trifirò G. Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000-2005. Eur J Neurol 2007 14:1317 1321.
5. Perucca E, Berlowitz D, Birnbaum A, Cloyd JC, Garrard J, Hanlon JT, Levy RH, Pugh MJ. Pharmacological and clinical aspects of antiepileptic drug use in the elderly. Epilepsy Res 2006 68 (Suppl. 1 S49 63.
6. Forcadas MI, Peña Mayor P, Salas Puig J. Special situations in epilepsy: women and the elderly. Neurologist 2007 6 (Suppl. 1 S52 61.
7. Wallace H, Shorvon S, Tallis R. Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2,052,922 and age-specific fertility rates of women with epilepsy. Lancet 1998 352:1970 1973.
8. Sheorajpanday RV, De Deyn PP. Epileptic fits and epilepsy in the elderly: general reflections, specific issues and therapeutic implications. Clin Neurol Neurosurg 2007 109:727 743.
9. Waterhouse EJ, DeLorenzo RJ. Status epilepticus in older patients: epidemiology and treatment options. Drugs Aging 2001 18:133 142.
10. Brodie MJ, Kwan P. Epilepsy in elderly people. BMJ 2005 331:1317 1322.
11. Cloyd J, Hauser W, Towne A, Ramsay R, Mattson R, Gilliam F, Walczak T. Epidemiological and medical aspects of epilepsy in the elderly. Epilepsy Res 2006 68 (Suppl. 1 S39 48.
12. Glauser T, Ben-Menachem E, Bourgeois B, Cnaan A, Chadwick D, Guerreiro C, Kalviainen R, Mattson R, Perucca E, Tomson T. ILAE treatment guidelines: evidence based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2006 47:1094 1120.
13. French JA, Kanner AM, Bautista J, Abou-Khalil B, Browne T, Harden CL, Theodore WH, Bazil C, Stern J, Schachter SC, Bergen D, Hirtz D, Montouris GD, Nespeca M, Gidal B, Marks WJ Jr., Turk WR, Fischer JH, Bourgeois B, Wilner A, Faught RE Jr., Sachdeo RC, Beydoun A, Glauser TA, Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology, Quality Standards Subcommittee of the American Academy of Neurology, American Epilepsy Society. Efficacy and tolerability of the newer antiepileptic drugs I: treatment of newer onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Epilepsia 2004 45:401 409.
14. French JA, Kanner AM, Bautista J, Abou-Khalil B, Browne T, Harden CL, Theodore WH, Bazil C, Stern J, Schachter SC, Bergen D, Hirtz D, Montouris GD, Nespeca M, Gidal B, Marks WJ Jr., Turk WR, Fischer JH, Bourgeois B, Wilner A, Faught RE Jr., Sachdeo RC, Beydoun A, Glauser TA, Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology, Quality Standards Subcommittee of the American Academy of Neurology, American Epilepsy Society. Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004 62:1261 1273. (Pubitemid 38526036)
15. Spina E, Perugi G. Antiepileptic drugs: indications other than epilepsy. Epileptic Disord 2004 6:57 75.
16. Steinman MA, Bero LA, Chren MM, Landefeld CS. Narrative review: the promotion of gabapentin: an analysis of internal industry documents. Ann Intern Med 2006 145:284 293.
17. Steinman MA, Harper GM, Chren MM, Landefeld CS, Bero LA. Characteristics and impact of drug detailing for gabapentin. PLoS Med 2007 4:e134.
18. Agenzia Italiana del Farmaco. Le note AIFA 2006-2007 per l'uso appropriato dei farmaci. Available at http://www.agenziafarmaco.it/wscs-render- attachment-by-id/111.90291.1168607405163575e.pdf?id=111.88204.1168596628882 (last accessed 25 September 2008).
19. Rochat P, Hallas J, Gaist D, Friis ML. Antiepileptic drug utilization: a Danish prescription database analysis. Acta Neurol Scand 2001 104:6 11.
20. Miketek G, Matek P. Prevalence of epilepsy in Croatia: a population-based survey. Acta Neurol Scand 2007 116:361 367.
21. Oun A, Haldre S, Mägi M. Use of antiepileptic drugs in Estonia: an epidemiologic study of adult epilepsy. Eur J Neurol 2006 13:465 470.
22. Oles KS, Gal P, Penry JK, Tapscott WK. Use of antiepileptic drugs in elderly population. Public Health Reports 1987 102:335 337.
23. Pugh MJ, Van Cott AC, Cramer JA, Knoefel JE, Amuan ME, Tabares J, Ramsay RE, Berlowitz DR, Treatment In Geriatric Epilepsy Research (TIGER) Team. Trends in antiepileptic drug prescribing for older patients with new onset epilepsy: 2000-2004. Neurology 2008 70:2171 2178.
24. Lawrenson R, Williams T, Farmer R. Clinical information for research: the use of general practice databases. J Pub Health Med 1999 21:299 304.
25. Piacentini N, Trifiró G, Tari M, Moretti S, Arcoraci V. Statin-macrolide interaction risk: a population based study throughout a general practice database. Eur J Clin Pharmacol 2005 61:615 620.
26. Trifirò G, Alacqua M, Corrao S, Tari M, Arcoraci V. Statins for the primary prevention of cardiovascular events in elderly patients: a picture from clinical practice without strong evidence from clinical trials. J Am Geriatr Soc 2008 56:175 177.
27. WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC Classification and DDD Assignment. Oslo:WHO Collaborating Centre for Drug Statistics and Methodology, 2001.
28. Ferrell BA. Pain management in elderly people. J Am Geriatr Soc 1991 39:64 73.
29. Galimberti CA, Magri F, Magnani B, Arbasino C, Cravello L, Marchioni E, Tartara A. Antiepileptic drug use and epileptic seizures in elderly nursing home residents: a survey in the province of Pavia, Northern Italy. Epilepsy Res 2006 68:1 8.
30. Banfi R, Borselli G, Marinai C, Borgheresi A, Cavalieri A. Epidemiological study of epilepsy by monitoring prescriptions of antiepileptic drugs. Pharm World Sci 1995 17:138 140.
31. Agenzia Italiana del Farmaco. L'uso dei farmaci in Italia. Rapporto OsMed 2007. Available at http://www.agenziafarmaco.it/allegati/rapporto-osmed-2007. pdf (last accessed 25 September 2008).
32. Garrison GD, Levin GM. Factors affecting prescribing of the newer antidepressants. Ann Pharmacother 2000 34:10 4.
33. Scottish Intercollegiate Guidelines Network. Diagnosis and management of epilepsy in adults. 2003. Scottish Intercollegiate Guidelines Network. Available at http://www.sign.ac.uk/pdf/sign70.pdf (last accessed 25/09/2008).
34. Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs. Lancet Neurol 2003 2:473 481. (Pubitemid 36876104)
35. National Collaborating Center for Primary Care. The Epilepsies: the Diagnosis and Management of the Epilepsies in Adults and Children in Primary and Secondary Care. London:National Institute for Clinical Excellence, 2004.