Systems-based design of bi-ligand inhibitors of oxidoreductases: Filling the chemical proteomic toolbox

Chemistry and Biology

Volumn 11, Issue 2, 2004, Pages 185-194

  Sem, Daniel S ^a,b   Bertolaet, Bonnie ^b   Baker, Brian ^b,c   Chang, Edcon ^b   Costache, Aurora D ^a   Coutts, Stephen ^b   Dong, Qing ^b   Hansen, Mark ^b   Hong, Victor ^b,d   Huang, Xuemei ^b   Jack, Richard M ^b   Kho, Richard ^b   Lang, Henk ^b   Ma, Chen Ting ^b   Meininger, David ^b,e   Pellecchia, Maurizio ^b,f   Pierre, Fabrice ^b   Villar, Hugo ^b   Yu, Lin ^b  

^a Marquette University   (United States)

^b Triad Therapeutics Inc   (United States)

^c VERTEX PHARMACEUTICALS   (United States)

^d MILLENNIUM PHARMACEUTICALS INC   (United States)

^e AMGEN INC   (United States)

^f BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; LIGAND; OXIDOREDUCTASE;

ANIMAL; ARTICLE; BINDING SITE; BIOLOGY; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; GENE LIBRARY; GENETICS; METHODOLOGY; MOLECULAR MIMICRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEOMICS; THERMODYNAMICS;

ANIMALS; BINDING SITES; COMPUTATIONAL BIOLOGY; DRUG DESIGN; ENZYME INHIBITORS; GENE LIBRARY; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR MIMICRY; NADH, NADPH OXIDOREDUCTASES; OXIDOREDUCTASES; PROTEOMICS; THERMODYNAMICS;

EID: 1542350238     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(04)00034-1     Document Type: Article

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