Antitumor properties of Ganoderma lucidum polysaccharides and terpenoids

Annual Review of Biomedical Sciences

Volumn 13, Issue , 2011, Pages 1-8

  Camargo, Marcela R ^a   Kaneno, Ramon ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Immunomodulation; Mushroom; Polysaccharides; Triterpenes; Tumor

Indexed keywords

CASPASE; GAMMA INTERFERON; GANODERIC ACID; GANODERMA LUCIDUM EXTRACT; GANODERMA LUCIDUM POLYSACCHARIDE; GANODERMANONTRIOL; INTERLEUKIN 10; INTERLEUKIN 12; POLYSACCHARIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; REACTIVE OXYGEN METABOLITE; TERPENOID; TRITERPENOID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; COLON CANCER; CYTOKINE PRODUCTION; CYTOTOXICITY; DENDRITIC CELL; DRUG ISOLATION; GANODERMA LUCIDUM; HUMAN; IMMUNOMODULATION; INNATE IMMUNITY; MACROPHAGE; NATURAL KILLER CELL; NONHUMAN; OXIDATIVE STRESS; SPLEEN LYMPHOCYTE; T LYMPHOCYTE; TH1 CELL; TUMOR CELL DESTRUCTION;

BASIDIOMYCOTA; GANODERMA LUCIDUM;

EID: 84856297897     PISSN: 18068774     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Cao LZ and Lin ZB. Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides. Immunology Letters 2002; 83: 163-9.
2. Chan WK, Lam TWD, Law HKW, Wong WT, Koo MWL, Lau A, Lau YL, Chan GCF. Ganoderma lucidum Mycelium and Spore Extracts as Natural Adjuvants for Immunotherapy. The Journal of Alternative and Complemnteary Medicine 2005;11:1047-57.
3. Chan WK, Law HKW, Lin ZB, Lau YL, Chan GCF. Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley. International Immunology 2007;19:891-9.
4. Chen HS, Tsai YF, Lin S, Lin CC, Khoo KH, Lin CH, Wong CH: Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides. Bioorg Med Chem 2004; 12:5595-601.
5. Cheng KC, Huang HC, Chen JH, Hsu JW, Cheng HC, Ou CH, Yang WB, Chen ST, Wong CH, Juan HF. Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction. BMC Genomics 2007; 8:411.
6. Chiu SW, Wang ZM, Leung TM, Moore D. Nutritional value of Ganoderma extract and assessment of its genotoxicity and antigenotoxicity using comet assays of mouse lymphocytes. Food Chem. Toxicol. 2000; 38:173-8.
7. Ha TB, Gerhäuser C, Zhang WD, Ho-Chong-Line N, Fourasté I. New lanostanoids from Ganoderma lucidum that induce NAD(P)H:quinone oxidoreductase in cultured hepalcic7 murine hepatoma cells. Planta Med. 2000; 66:681-4.
8. Harhaji Trajković LM, Mijatović SA, Maksimović-Ivanić DD, Stojanović ID, Momcilović MB, Tufegdzić SJ, Maksimović VM, Marjanović ZS, Stosić-Grujicić SD. Anticancer properties of Ganoderma lucidum methanol extracts in vitro and in vivo. Nutr Cancer. 2009;61:696-707.
9. Hsu HY, Hua KF, Lin CC, Lin CH, Hsu J, Wong CH. Extract of Reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways. J Immunol 2004;173:5989-99.
10. Jang KJ, Han MH, Lee BH, Kim BW, Kim CH, Yoon HM, Choi YH. Induction of Apoptosis by Ethanol Extracts of Ganoderma lucidum in Human Gastric Carcinoma Cells. J Acupunct Meridian Stud 2010;3:24-31.
11. Jedinak A, Thyagarajan-Sahu A, Jiang J, Sliva D. Ganodermanontriol, a lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer cells through ß-catenin signaling. Int J Oncol. 2011 Mar;38:761-7.
12. Jiang J, Grieb B, Thyagarajan A, Sliva D. Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-B signaling. International Journal of Molecular Medicine 2008; 21: 577-84.
13. Jiang J, Slivova V, Harvey K, Valachovicova T, Sliva D: Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signaling. Nutr Cancer 2004; 9: 209-16.
14. Lakshmi B, Ajith TA, Sheena N, Gunapalan N, Janardhanan KK. Antiperoxidative, anti-inflammatory, and antimutagenic activities of ethanol extract of the mycelium of Ganoderma lucidum occurring in South India. Teratog Carcinog Mutagen. 2003;1:85-97.
15. Lee JM, Kwon H, Jeong H, Lee JW, Lee SY, Baek SJ, Surh YJ. Inhibition of lipid peroxidation and oxidative DNA damage by Ganoderma lucidum. Phytother Res. 2001;15:245-9.
16. Lee MK, Hung TM, Cuong TD, Na MK, Kim JC, Jung Kim E, Sung Park H, Choi JS, Lee I, Bae K, Hattori M and Min BS. Ergosta-7,22-diene-2β,3α,9α-triol from the Fruit Bodies of Ganoderma lucidum Induces Apoptosis in Human Myelocytic HL-60 Cells. Phytother Res. 2011; on line.
17. Li CH, Chen PY, Chang UM, Kan LS, Fang WH, Tsai KS and Lin SB: Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells. Life Sci 2005; 77: 252-65.
18. Li N, Hu YL, He CX, Hu CJ, Zhou J, Tang GP, Gao JQ. Preparation, characterisation and anti-tumour activity of Ganoderma lucidum polysaccharide nanoparticles. Journal of Pharmacy and Pharmacology 2010; 62: 139-44.
19. Lieu CW, Lee SS, Wang SY. The effect of Ganoderma lucidum on induction of differentiation in leukemic U937 cells. Anticancer Res. 1992;12:1211-5.
20. Lin ZB. Cellular and Molecular Mechanisms of Immuno-modulation by Ganoderma lucidum. J Pharmacol Sci 2005; 99:144-53.
21. Lin YL, Lee LL, Hou MS, Chiang BL. Polysaccharide Purified from Ganoderma lucidum Induces Gene Expression Changes in Human Dendritic Cells and Promotes T Helper 1 Immune Response in BALB/c Mice. Molecular Pharmacology 2006; 70:637-44.
22. Lu H, Kyo E, Uesaka T, Katoh O, Watanabe H. Prevention of development of N,N'-dimethylhydrazineinduced colon tumors by a water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia in male ICR mice. Int J Mol Med. 2002;9:113-7.
23. Lu H, Kyo E, Uesaka T, Katoh O, Watanabe H. A water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia suppresses azoxymethane-induction of colon cancers in male F344 rats. Oncol Rep. 2003;10:375-9.
24. Lu H, Uesaka T, Katoh O, Kyo E, Watanabe H. Prevention of the development of preneoplastic lesions, aberrant crypt foci, by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male F344 rats. Oncol Rep. 2001;8:1341-5.
25. Maruyama H, Yamazaki K, Murofushi S, Konda C, Ikekawa T. Antitumor activity of Sarcodon aspratus (Berk.) S. Ito and Ganoderma lucidum (Fr.) Karst. J Pharmacobiodyn. 1989;12:118-23.
26. Min BS, Gao JJ, Nakamura N, Hattori M. Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells. Chem Pharm Bull. 2000; 48:1026-33.
27. Mizushina Y, Hanashima L, Yamaguchi T, Takemura M, Sugawara F, Saneyoshi M, Matsukage A, Yoshida S, Sakaguchi K. A mushroom fruiting body-inducing substance inhibits activities of replicative DNA polymerases, Biochem. Biophys. Res. Commun. 1998; 249:17-22.
28. Oka S, Tanaka S, Yoshida S, Hiyama T, Ueno Y, Ito M, Kitadai Y, Yoshihara M, Chayama K. A watersoluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas. Hiroshima J Med Sci. 2010; 59:1-6.
29. Rubel R, Santa HSD, Bonatto SJR, Bello S, Fernandes LC, Bernardi RD, Gern J, Santos CAM, Soccol CR. Medicinal Mushroom Ganoderma lucidum (Leyss: Fr) Karst. Triggers Immunomodulatory Effects and Reduces Nitric Oxide Synthesis in Mice. Med Food 2010; 13:142-8.
30. Shao BM, Dai H, Xu W, Lin ZB, Gao XM. Immune receptors for polysaccharides from Ganoderma lucidum. Biochem. Biophys. Res. Commun. 2004; 323:133.
31. Sliva D, Labarrere C, Slivova V, Sedlak M, Lloyd F P, Ho NWY. Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells. Biochemical and Biophysical Research Communications 2002; 298:603-12.
32. Sliva D. Ganoderma lucidum (Reishi) in Cancer Treatment. Integrative Cancer Therapies 2003; 2:358-64.
33. Tang W, Liu JW, Zhao WM, Wei DZ and Zhong JJ: Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life Sci 2006; 80: 205-11.
34. Wang SY, Hsu ML, Hsu HC, Tzeng CH, Lee SS, Shiao MS, Ho CK. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int J Cancer. 1997;70:699-705.
35. Wang YY, Khoo KH, Chen ST, Lin CC, Wong CH, Lin CH: Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities. Bioorg Med Chem 2002;10:1057-62.
36. Xu JW, Zhao W, Zhong JJ. Biotechnological production and application of ganoderic acids. Appl Microbiol Biotechnol. 2010; 87:457-66.
37. Yue QX, Song XY, Ma C, Feng LX, Guan SH, Wu HY, Yang M, Jiang BJ, Liu X, Cui YJ, Guo DA. Effects oftriterpenesfrom Ganoderma lucidum on proteinexpressionprofile of HeLa cells. Phytomedicine 2010; 17: 606-13.
38. Zhang GL, Wang YH, Ni W, Teng HL, Lin ZB. Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice. Acta Pharmacol. Sin. 2002; 23:787-91.
39. Zhang J, Tang Q, Zhou C, Jia W, Silva L, Nguyen LD, W Reutter, Fan H. GLIS, a bioactive proteoglycan fraction from Ganoderma lucidum, displays anti-tumour activity by increasing both humoral and cellular immune response. Life Sciences 2010; 87: 628-37.
40. Zhao S, Ye G, Fu G, Cheng JX, Yang BB, Peng C. Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin. Int J Oncol. 2011; 38:1319-27.
41. Zhuang SR et al. Effect of Citronellol and the Chinese Medical Herb Complex on Cellular Immunity of Cancer Patients Receiving Chemotherapy/Radiotherapy. Phytother. Res. 2009; 23:785-90.