-
1
-
-
0028243033
-
Cellular and molecular biology of Alzheimer's disease and animal models
-
DOI 10.1146/annurev.med.45.1.435
-
Price, D. L.; Sisodia, S. S. Cellular and Molecular Biology of Alzheimer's Disease and Animal Models. Ann. Rev. Med. 1994, 45, 435-446. (Pubitemid 24158173)
-
(1994)
Annual Review of Medicine
, vol.45
, pp. 435-446
-
-
Price, D.L.1
Sisodia, S.S.2
-
3
-
-
0035943345
-
A portrait of Alzheimer secretases - New features and familiar faces
-
DOI 10.1126/science.1064638
-
Esler, W. P.; Wolfe, M. S. A Portrait of Alzheimer Secretases-New Features and Familial Faces. Science 2001, 293, 1449-1454. (Pubitemid 32801541)
-
(2001)
Science
, vol.293
, Issue.5534
, pp. 1449-1454
-
-
Esler, W.P.1
Wolfe, M.S.2
-
4
-
-
0037162725
-
New Alzheimer's treatments that may ease the mind
-
DOI 10.1126/science.297.5585.1260
-
Helmuth, L. New Therapies: New Alzheimer's Treatments that May Ease the Mind. Science 2002, 297, 1260-1262. (Pubitemid 34913141)
-
(2002)
Science
, vol.297
, Issue.5585
, pp. 1260-1262
-
-
Helmuth, L.1
-
5
-
-
33644884230
-
Immunotherapy for Alzheimer's disease: Potential problems and possible solutions
-
Cribbs, D. H.; Agadjanyan, M. G. Immunotherapy for Alzheimer's Disease: Potential Problems and Possible Solutions. Curr. Immunol. Rev. 2005, 1, 95.
-
(2005)
Curr. Immunol. Rev.
, vol.1
, pp. 95
-
-
Cribbs, D.H.1
Agadjanyan, M.G.2
-
6
-
-
76849091134
-
Can Alzheimer disease be prevented by amyloid-β immunotherapy?
-
Lemere, C. A.; Masliah, E. Can Alzheimer Disease be Prevented by Amyloid-β Immunotherapy? Nat. Rev. Neurol. 2010, 6, 108-119.
-
(2010)
Nat. Rev. Neurol.
, vol.6
, pp. 108-119
-
-
Lemere, C.A.1
Masliah, E.2
-
7
-
-
0033536163
-
Immunization with amyloid-β attenuates Alzheimer disease-like pathology in the PDAPP mouse
-
DOI 10.1038/22124
-
Schenk, D.; Barbour, R.; Dunn, W.; Gordon, G.; Grajeda, H.; Guido, T.; Hu, K.; Huang, J.; Johnson-Wood, K.; Khan, K.; Kholodenko, D.; Lee, M.; Liao, Z.; Lieberurg, I.; Motter, R.; Mutter, L.; Soriano, F.; Shopp, G.; Vasquez, N.; Vandevert, C.; Walker, S.; Wogulis, M.; Yednock, T.; Games, D.; Seubert, P. Immunization with Amyloid-beta Attenuates Alzheimer Disease-like Pathology in the PDAPP Mouse. Nature 1999, 400, 173-177. (Pubitemid 29327547)
-
(1999)
Nature
, vol.400
, Issue.6740
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guldo, T.6
Hu, K.7
Huang, J.8
Johnson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Motter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandevert, C.20
Walker, S.21
Wogulis, M.22
Yednock, T.23
Games, D.24
Seubert, P.25
more..
-
8
-
-
0036780877
-
Opinion: Amyloid-β immunotherapy for Alzheimer's disease: The end of the beginning
-
Schenk, D. Opinion: Amyloid-β Immunotherapy for Alzheimer's Disease: The End of the Beginning. Nat. Rev. Neurosci. 2002, 3, 824.
-
(2002)
Nat. Rev. Neurosci.
, vol.3
, pp. 824
-
-
Schenk, D.1
-
9
-
-
84984755327
-
A β peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
-
DOI 10.1038/35050116
-
Morgan, D.; Diamond, D. M.; Gottschall, P. E.; Ugen, K. E.; Dickey, C.; Hardy, J.; Duff, K.; Jantzen, P.; DiCarlo, G.; Wilcock, D.; Connor, K.; Hatcher, J.; Hope, C.; Gordon, M.; Arendash, G.W. Aβ Peptide Vaccination Prevents Memory Loss in an Animal Model of Alzheimer's Disease. Nature 2000, 408, 982-985. (Pubitemid 32101645)
-
(2000)
Nature
, vol.408
, Issue.6815
, pp. 982-985
-
-
Morgan, D.1
Diamond, D.M.2
Gottschall, P.E.3
Ugen, K.E.4
Dickey, C.5
Hardy, J.6
Duff, K.7
Jantzen, P.8
DiCarlo, G.9
Wilcock, D.10
Connor, K.11
Hatcher, J.12
Hope, C.13
Gordon, M.14
Arendash, G.W.15
-
10
-
-
0034718233
-
Transgenic mouse models of Alzheimer's disease
-
DOI 10.1016/S0925-4439(00)00033-8, PII S0925443900000338
-
Janus, C.; Chishti, M. A.; Westaway, D. Transgenic Mouse Models of Alzheimer's Disease. Biochim. Biophys. Acta 2000, 1502, 63-75. (Pubitemid 30433856)
-
(2000)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1502
, Issue.1
, pp. 63-75
-
-
Janus, C.1
Chishti, M.A.2
Westaway, D.3
-
11
-
-
0033835996
-
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
DOI 10.1038/78682
-
Bard, F.; Cannon, C.; Barbour, R.; Burke, R. L.; Games, D.; Grajeda, H.; Guido, T.; Hu, K.; Huang, J.; Johnson-Wood, K.; Khan, K.; Kholodenko, D.; Lee, M.; Lieberburg, I.; Motter, R.; Nguyen, M.; Soriano, F.; Vasquez, N.; Weiss, K.; Welch, B.; Seubert, P.; Schenk, D.; Yednock, T. Peripherally Administered Antibodies Against Amyloid β-Peptide Enter the Central Nervous System and Reduce Pathology in a Mouse Model of Alzheimer Disease. Nat. Med. 2000, 6, 916-919. (Pubitemid 30644751)
-
(2000)
Nature Medicine
, vol.6
, Issue.8
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
Burke, R.-L.4
Games, D.5
Grajeda, H.6
Guido, T.7
Hu, K.8
Huang, J.9
Johnson-Wood, K.10
Khan, K.11
Kholodenko, D.12
Lee, M.13
Lieberburg, I.14
Motter, R.15
Nguyen, M.16
Soriano, F.17
Vasquez, N.18
Weiss, K.19
Welch, B.20
Seubert, P.21
Schenk, D.22
Yednock, T.23
more..
-
12
-
-
0035902619
-
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
-
DOI 10.1073/pnas.151261398
-
DeMattos, R. B.; Bales, K. R.; Cummins, D. J.; Dodart, J. C.; Paul, S. M.; Holtzman, D. M. Peripheral Anti-Aβ Antibody Alters CNS and Plasma Aβ Clearance and Decreases Brain Aβ Burden in a Mouse Model of Alzheimer's Disease. Proc. Natl. Acad. Sci. USA 2001, 98, 8850-8855. (Pubitemid 32678116)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.15
, pp. 8850-8855
-
-
DeMattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
Dodart, J.-C.4
Paul, S.M.5
Holtzman, D.M.6
-
13
-
-
0037384333
-
h2 responses to immunization with β-amyloid
-
DOI 10.1093/intimm/dxg049
-
Cribbs, D. H.; Ghochikyan, A.; Vasilevko, V.; Tran, M.; Petrushina, I.; Sadzikava, N.; Babikyan, D.; Kesslak, P.; Kieber-Emmons, T.; Cotman, C. W.; Agadjanyan, M. G. Adjuvant-dependent Modulation of Th1 and Th2 Responses to Immunization with β-Amyloid. Int. Immunol. 2003, 15, 505-514. (Pubitemid 36432403)
-
(2003)
International Immunology
, vol.15
, Issue.4
, pp. 505-514
-
-
Cribbs, D.H.1
Ghochikyan, A.2
Vasilevko, V.3
Tran, M.4
Petrushina, I.5
Sadzikava, N.6
Babikyan, D.7
Kesslak, P.8
Kieber-Emmons, T.9
Cotman, C.W.10
Agadjanyan, M.G.11
-
14
-
-
0036127580
-
Set back to Alzheimer vaccine studies
-
Birmingham, K.; Frantz, S. Set Back Alzheimer Vaccine Studies. Nat. Med. 2002, 8, 199-200. (Pubitemid 34250084)
-
(2002)
Nature Medicine
, vol.8
, Issue.3
, pp. 199-200
-
-
Birmingham, K.1
Frantz, S.2
-
15
-
-
1042265187
-
Neuropathology and pathogenesis of encephalitis following amyloid-β immunization in Alzheimer's disease
-
Ferrer, I.; Boada Rovira, M.; Sanchez Guerra, M. L.; Rey, M. J.; Costa-Jussa, F. Neuropathology and Pathogenesis of Encephalitis Following Amyloid-β Immunization in Alzheimer's Disease. Brain Pathol. 2004, 14, 11-20. (Pubitemid 38200585)
-
(2004)
Brain Pathology
, vol.14
, Issue.1
, pp. 11-20
-
-
Ferrer, I.1
Boada Rovira, M.2
Sanchez Guerra, M.L.3
Rey, M.J.4
Costa-Jussa, F.5
-
16
-
-
0037393454
-
Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: A case report
-
DOI 10.1038/nm840
-
Nicoll, J. A.; Wilkinson, D.; Holmes, C.; Steart, P.; Markham, H.; Weller, R. O. Neuropathology of Human Alzheimer Disease after Immunization with Amyloid-β Peptide: A Case Report. Nat. Med. 2003, 9, 448-452. (Pubitemid 36460079)
-
(2003)
Nature Medicine
, vol.9
, Issue.4
, pp. 448-452
-
-
Nicolll, J.A.R.1
Wilkinson, D.2
Holmes, C.3
Steart, P.4
Markham, H.5
Weller, R.O.6
-
17
-
-
0842269766
-
Anti-Aβ: The good, the bad, and the unforeseen
-
Broytman, O.; Malter, J. S. Anti-Aβ: The Good, the Bad, and the Unforeseen. J. Neurosci. Res. 2004, 75, 301-306.
-
(2004)
J. Neurosci. Res.
, vol.75
, pp. 301-306
-
-
Broytman, O.1
Malter, J.S.2
-
18
-
-
41949139857
-
Enhanced Th2 immunity after DNA prime-protein boost immunization with amyloid β (1-42) plus CpG oligodeoxynucleotides in aged rats
-
Subramanian, S.; Divya Shree, A. N. Enhanced Th2 Immunity after DNA Prime-Protein Boost Immunization with Amyloid β (1-42) plus CpG Oligodeoxynucleotides in Aged Rats. Neurosci. Lett. 2008, 436, 219-222.
-
(2008)
Neurosci. Lett.
, vol.436
, pp. 219-222
-
-
Subramanian, S.1
Divya Shree, A.N.2
-
19
-
-
77950188972
-
Design and development of non-fibrillar amyloid β as a potential Alzheimer vaccine
-
Subramanian, S.; Bandopadhyay, D.; Mishra, P. K.; Mathew, M.; John, M. Design and Development of Non-fibrillar Amyloid β as a Potential Alzheimer Vaccine. Biochem. Biophys. Res. Commun. 2010, 394, 393-397.
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.394
, pp. 393-397
-
-
Subramanian, S.1
Bandopadhyay, D.2
Mishra, P.K.3
Mathew, M.4
John, M.5
-
20
-
-
12444268257
-
Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from β-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide
-
Agadjanyan, M. G.; Ghochikyan, A.; Petrushina, I.; Vasilevko, V.; Movsesyan, N.; Mkrtichyan, M.; Saing, T.; Cribbs, D. H. Prototype Alzheimer's Disease Vaccine using the Immunodominant B Cell Epitope from β-amyloid and Promiscuous T cell Epitope Pan HLA DR-binding Peptide. J. Immunol. 2005, 174, 1580-1586.
-
(2005)
J. Immunol.
, vol.174
, pp. 1580-1586
-
-
Agadjanyan, M.G.1
Ghochikyan, A.2
Petrushina, I.3
Vasilevko, V.4
Movsesyan, N.5
Mkrtichyan, M.6
Saing, T.7
Cribbs, D.H.8
-
21
-
-
33344460820
-
Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Aβ antibody response with Alum to Quil A adjuvant switch
-
DOI 10.1016/j.vaccine.2005.11.039, PII S0264410X05011916
-
Ghochikyan, A.; Mkrtichyan, M.; Petrushina, I.; Movsesyan, N.; Karapetyan, A.; Cribbs, D. H.; Agadjanyan, M. G. Prototype Alzheimer's Disease Epitope Vaccine Induced Strong Th2-type Anti-Aβ Antibody Response with Alum to Quil A Adjuvant Switch. Vaccine 2006, 24, 2275-2282. (Pubitemid 43290409)
-
(2006)
Vaccine
, vol.24
, Issue.13
, pp. 2275-2282
-
-
Ghochikyan, A.1
Mkrtichyan, M.2
Petrushina, I.3
Movsesyan, N.4
Karapetyan, A.5
Cribbs, D.H.6
Agadjanyan, M.G.7
-
22
-
-
34247092861
-
Dendrimeric Aβ1-15 is an effective immunogen in wildtype and APP-tg mice
-
DOI 10.1016/j.neurobiolaging.2006.04.007, PII S0197458006001230
-
Seabrook, T. J.; Thomas, K.; Jiang, L.; Bloom, J.; Spooner, E.; Maier, M.; Bitan, G.; Lemere, C. A. Dendrimeric Aβ1-15 is an Effective Immunogen in Wildtype and APP-tg Mice. Neurobiol. Aging 2007, 28, 813-823. (Pubitemid 46589741)
-
(2007)
Neurobiology of Aging
, vol.28
, Issue.6
, pp. 813-823
-
-
Seabrook, T.J.1
Thomas, K.2
Jiang, L.3
Bloom, J.4
Spooner, E.5
Maier, M.6
Bitan, G.7
Lemere, C.A.8
-
23
-
-
34347241390
-
Expression, purification and characterization of a synthetic gene encoding human amyloid ß(Aß1-42) in Escherichia coli
-
Subramanian, S.; Divya Shree, A. N. Expression, Purification and Characterization of a Synthetic Gene Encoding Human Amyloid β (Aβ1-42) in Escherichia coli. Indian J. Biochem. Biophys. 2007, 44, 71-75. (Pubitemid 47409445)
-
(2007)
Indian Journal of Biochemistry and Biophysics
, vol.44
, Issue.2
, pp. 71-75
-
-
Subramanian, S.1
Shree, A.N.D.2
-
24
-
-
33846430934
-
Aβ-immunotherapy for Alzheimer's disease using mannan-amyloid-beta peptide immunoconjugates
-
DOI 10.1089/dna.2006.25.571
-
Ghochikyan, A.; Petrushina, I.; Lees, A.; Vasilevko, V.; Movsesyan, N.; Karapetyan, A.; Agadjanyan, M. G.; Cribbs, D. H. Aβ-immunotherapy for Alzheimer's Disease using Mannan-amyloid-beta Peptide Immunoconjugates. DNA Cell Biol. 2006, 25, 571-580. (Pubitemid 46141328)
-
(2006)
DNA and Cell Biology
, vol.25
, Issue.10
, pp. 571-580
-
-
Ghochikyan, A.1
Petrushina, I.2
Lees, A.3
Vasilevko, V.4
Movsesyan, N.5
Karapetyan, A.6
Agadjanyan, M.G.7
Cribbs, D.H.8
-
25
-
-
33644920371
-
1-42 in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Aβ
-
1-42 in Young and Aged Canines: Antibody Generation and Characteristics, and Effects on CSF and Brain Aβ. Vaccine 2006, 24, 2824-2834.
-
(2006)
Vaccine
, vol.24
, pp. 2824-2834
-
-
Head, E.1
Barrett, E.G.2
Murphy, M.P.3
Das, P.4
Nistor, M.5
Sarsoza, F.6
Glabe, C.C.7
Kayed, R.8
Milton, S.9
Vasilevko, V.10
Milgram, N.W.11
Agadjanyan, M.12
Cribbs, D.H.13
Cotman, C.W.14
-
26
-
-
25144520056
-
Modulation of the humoral and cellular immune response in Aβ immunotherapy by the adjuvants monophosphoryl lipid A (MPL), cholera toxin B subunit (CTB) and E. coli enterotoxin LT(R192G)
-
DOI 10.1016/j.vaccine.2005.06.018, PII S0264410X05006171
-
Maier, A. M.; Seabrook, T. J.; Lemere, C. A. Modulation of the Humoral and Cellular Immune Response in Aβ Immunotherapy by the Adjuvants Monophosphoryl Lipid A (MPL), Cholera Toxin B Subunit (CTB) and E. coli Enterotoxin LT (R192G). Vaccine 2005, 23, 5149-5159. (Pubitemid 41356545)
-
(2005)
Vaccine
, vol.23
, Issue.44
, pp. 5149-5159
-
-
Maier, M.1
Seabrook, T.J.2
Lemere, C.A.3
-
27
-
-
0034530636
-
Nasal Aβ treatment induces anti-Aβ antibody production and decreases cerebral amyloid burden in PD-APP mice
-
Lemere, C. A.; Maron, R.; Spooner, E. T.; Grenfell, T. J.; Mori, C.; Desai, R.; Hancock, W. W.; Weiner, H. L.; Selkoe, D. J. Nasal A Beta Treatment Induces Anti-A Beta Antibody Production and Decreases Cerebral Amyloid Burden in PD-APP Mice. Ann. N Y Acad. Sci. 2000, 920, 328-331. (Pubitemid 32056589)
-
(2000)
Annals of the New York Academy of Sciences
, vol.920
, pp. 328-331
-
-
Lemere, C.A.1
Maron, R.2
Spooner, E.T.3
Grenfell, T.J.4
Mori, C.5
Desai, R.6
Hancock, W.W.7
Weiner, H.L.8
Selkoe, D.J.9
-
28
-
-
0033801852
-
Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease
-
Weiner, H. L.; Lemere, C. A.; Maron, R.; Spooner, E. T.; Grenfell, T. J.; Mori, C.; Issazadeh, S.; Hancock, W. W.; Selkoe, D. J. Nasal Administration of Amyloid-beta Peptide Decreases Cerebral Amyloid Burden in a Mouse Model of Alzheimer's Disease. Ann. Neurol. 2000, 48, 567-579.
-
(2000)
Ann. Neurol.
, vol.48
, pp. 567-579
-
-
Weiner, H.L.1
Lemere, C.A.2
Maron, R.3
Spooner, E.T.4
Grenfell, T.J.5
Mori, C.6
Issazadeh, S.7
Hancock, W.W.8
Selkoe, D.J.9
-
29
-
-
10744223260
-
Generation and characterization of the humoral immune response to DNA immunization with a chimeric β-amyloid-interleukin-4 minigene
-
DOI 10.1002/eji.200324000
-
Ghochikyan, A.; Vasilevko, V.; Petrushina, I.; Movsesyan, N.; Babikyan, D.; Tian, W.; Sadzikava, N.; Ross, T. M.; Head, E.; Cribbs, D. H.; Agadjanyan, M. G. Generation and Characterization of the Humoral Immune Response to DNA Immunization with a Chimeric β Amyloid-interleukin-4 Minigene. Eur. J. Immunol. 2003, 33, 3232-3241. (Pubitemid 37541099)
-
(2003)
European Journal of Immunology
, vol.33
, Issue.12
, pp. 3232-3241
-
-
Ghochikyan, A.1
Vasilevko, V.2
Petrushina, I.3
Movsesyan, N.4
Babikyan, D.5
Tian, W.6
Sadzikava, N.7
Ross, T.M.8
Head, E.9
Cribbs, D.H.10
Agadjanyan, M.G.11
-
30
-
-
0035964312
-
Immune hyporesponsiveness to amyloid β-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease
-
DOI 10.1073/pnas.191118298
-
Monsego, A.; Maron, R.; Zota, V.; Selkoe, D. J.; Weiner, H. L. Immune Hyporesponsiveness to Amyloid-beta Peptide in Amyloid Precursor Protein Transgenic Mice: Implications for the Pathogenesis and Treatment of Alzheimers Disease. Proc. Natl. Acad. Sci. 2001, 98, 10273-10278. (Pubitemid 32803010)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.18
, pp. 10273-10278
-
-
Monsonego, A.1
Maron, R.2
Zota, V.3
Selkoe, D.J.4
Weiner, H.L.5
-
31
-
-
0345862278
-
Effect of Different Anti-Aβ Antibodies on Aβ Fibrillogenesis as Assessed by Atomic Force Microscopy
-
DOI 10.1016/j.jmb.2003.11.019
-
Legleiter, J.; Czilli, D. L.; Gitter, B.; DeMattos, R. B.; Holtzman, D. M.; Kowalewski, T. Effect of Different anti-Aβ Antibodies on Aβ Fibrillogenesis as Assessed by Atomic Force Microscopy. J. Mol. Biol. 2004, 335, 997-1006. (Pubitemid 38091605)
-
(2004)
Journal of Molecular Biology
, vol.335
, Issue.4
, pp. 997-1006
-
-
Legleiter, J.1
Czilli, D.L.2
Gitter, B.3
DeMattos, R.B.4
Holtzman, D.M.5
Kowalewski, T.6
|