Perfusion pressure manipulation in porcine sepsis: Effects on intestinal hemodynamics

Physiological Research

Volumn 55, Issue 5, 2006, Pages 527-533

  Krouzecky A ^a   Matejovic M ^a   Radej J ^a   Rokyta Jr , R ^a   Novak I ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Microcirculation; Norepinephrine; Perfusion pressure; Sepsis; Shock

Indexed keywords

NORADRENALIN;

ANIMAL EXPERIMENT; ARTICLE; CARBON DIOXIDE TENSION; CONTROLLED STUDY; FEMALE; HEMODYNAMICS; ILEUM MUCOSA; INTESTINE BLOOD FLOW; MALE; MEAN ARTERIAL PRESSURE; MESENTERY BLOOD FLOW; MICROVASCULATURE; NONHUMAN; PERFUSION PRESSURE; PSEUDOMONAS AERUGINOSA; SEPSIS; SWINE;

ANIMALS; BLOOD PRESSURE; CARDIAC OUTPUT; FEMALE; HEART RATE; INTESTINAL MUCOSA; MALE; MESENTERIC ARTERIES; NOREPINEPHRINE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; PULMONARY ARTERY; REGIONAL BLOOD FLOW; SEPSIS; SUS SCROFA; VASCULAR RESISTANCE; VASOCONSTRICTOR AGENTS;

EID: 33750246416     PISSN: 08628408     EISSN: 08628408     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. ALBANESE J, LEONE M, GARNIER F, BOURGOIN A, ANTONINI F, MARTIN C: Renal effects of norepinephrine in septic and nonseptic patients. Chest 126: 534-539, 2004.
2. ASFAR P, DE BACKER D, MEIER-HELLMANN A, RADERMACHER P, SAKKA SG: Influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock. Crit Care 8: 170-179, 2004.
3. BELLOMO R, DI GIANTOMASSO D: Noradrenaline and the kidney: friends or foes? Crit Care 5: 294-298, 2001.
4. BELLOMO R, KELLUM JA, WISNIEWSKI SR, PINSKY MR: Effects of norepinephrine on the renal vasculature in normal and endotoxemic dogs. Am J Respir Crit Care Med 159: 1186-1192, 1999.
5. BOURGOIN A, LEONE M, DELMAS A, GARNIER F, ALBANESE J, MARTIN C: Increasing mean arterial pressure in patients with septic shock: Effects on oxygen variables and renal function. Crit Care Med 33: 780-786, 2005.
6. DELLINGER RP, CARLET JM, MASUR H, GERLACH H, CALANDRA T, COHEN J, GEA-BANACLOCHE J, KEH D, MARSHALL JC, PARKER MM, RAMSAY G, ZIMMERMAN JL, VINCENT JL, LEVY MM: Surviving sepsis campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med 30: 536-555, 2004.
7. DI GIANTOMASSO D, MAY CN, BELLOMO R: Norepinephrine and vital organ blood flow during experimental hyperdynamic sepsis. Intensive Care Med 29: 1774-1781, 2003.
8. HASSOUN HT, KONE BC, MERCER DW, MOODY FG, WEISBRODT NW, MOORE FA: Post-injury multiple organ failure: the role of the gut. Shock 15: 1-10, 2001.
9. JOHNSON PC: Autoregulation of blood flow. Circ Res 59: 483-495, 1986.
10. LEDOUX D, ASTIZ ME, CARPATI CHM, RACKOW EC: Effects of perfusion pressure on tissue perfusion in septic shock. Crit Care Med 28: 2729-2732, 2000.
11. LEVY B, MANSART A, BOLLAERT PE, FRANCK P, MALLIE JP: Effects of epinephrine and norepinephrine on hemodynamics, oxidative metabolism, and organ energetics in endotoxemic rats. Intensive Care Med 29: 292-300, 2003.
12. MARIK P: Renal dose norepinephrine. Chest 126: 335-337, 2004.
13. MARTIN C, PAPAZIAN L, PERRIN G, SAUX P, GOUIN F: Norepinephrine or dopamine for the treatment of hyperdynamic septic shock? Chest 103: 1826-1831, 1993.
14. MATĚJOVIČ M, KROUŽECKÝ A, MARTÍNKOVÁ V, ROKYTA R Jr., KRÁLOVÁ H, TRESKA V, RADERMACHER P, NOVÁK I: Selective inducible nitric oxide synthase inhibition during long-term hyperdynamic porcine bacteremia. Shock 21: 458-465, 2004.
15. MATĚJOVIČ M, KROUŽECKÝ A, MARTÍNKOVÁ V, ROKYTA R Jr., RADĚJ J, KRÁLOVÁ H, TRESKA V, RADERMACHER P, NOVÁK I: Tempol, an intracellular free radical scavenger, during long term hyperdynamic porcine bacteremia. Crit Care Med 33: 1057-1063, 2005.
16. PINSKY M: Regional blood flow distribution. In: The Splanchnic Circulation. No Longer a Silent Partner. M PINSKY, J DHAINAUT, A ARTIGAS (eds), Springer, Berlin, 1995, pp 1-13.
17. REISBECK M, ASTIZ ME: Arterial pressure, vasopressors and septic shock: higher is not necessarily better. Crit Care Med 33: 906-907, 2005.
18. TERBORG C, SCHUMMER W, ALBRECHT M, REINHART K, WEILLER C, ROTHER J: Dysfunction of vasomotor reactivity in severe sepsis and septic shock. Intensive Care Med 27: 1231-1234, 2001.
19. TRÄGER K, DEBACKER D, RADERMACHER P: Metabolic alterations in sepsis and vasoactive drug-related metabolic effects. Curr Opin Crit Care 9: 271-278, 2003a.
20. TRÄGER K, RADERMACHER P, LEVERVE X: The adrenergic coin: perfusion and metabolism. Intensive Care Med 29: 150-153, 2003b.
21. TREGGIARI MM, ROMAND JA, BURGENER D, SUTER PM, ANEMAN A: Effect of increasing norepinephrine dosage on regional blood flow in a porcine model of endotoxin shock. Crit Care Med 30: 1334-1339, 2002.
22. 2 gap is associated with impaired villus microcirculation in endotoxic pigs. Intensive Care Med 27: 757-766, 2001.
23. 2 difference as a continuous indicator of splanchnic perfusion. Br J Anaesth 85: 563-569, 2000a.
24. 2 gradient does not reflect systemic and splanchnic hemodynamic or oxygen transport after cardiac surgery. Shock 14: 13-17, 2000b.
25. VINCENT JL: Hemodynamic support in septic shock. Intensive Care Med 27: S80-S92, 2001.
26. ZHANG H, SMAIL N, CABRAL A, ROGIERS P, VINCENT JL: Effect of norepinephrine on regional blood flow and oxygen extraction capabilities during endotoxic shock. Am J Respir Crit Care Med 155: 1965-1971, 1997.