Dietary antioxidants prevent age-related retinal pigment epithelium actin damage and blindness in mice lacking αvβ5 integrin

Free Radical Biology and Medicine

Volumn 52, Issue 3, 2012, Pages 660-670

  Yu, Chia Chia ^a   Nandrot, Emeline F ^b,c,d   Dun, Ying ^a   Finnemann, Silvia C ^a  

^a FORDHAM UNIVERSITY   (United States)

^b INSERM   (France)

^c INSTITUT DE LA VISION   (France)

^d CNRS   (France)

Author keywords

4 Hydroxynonenal; Actin; Age related blindness; Antioxidant; Cytoskeleton; Free radicals; Lipofuscin; Oxidative stress; Protein oxidation; Retina; Retinal pigment epithelium

Indexed keywords

4 HYDROXYNONENAL; ACTIN; ALPHAVBETA5 INTEGRIN; ANTIOXIDANT; MARIGOLD EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; XANTHOPHYLL; ZEAXANTHIN;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLINDNESS; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOSKELETON; DIET SUPPLEMENTATION; ELECTRORETINOGRAPHY; EPITHELIUM CELL; EXTRACTION; FLUORESCENCE MICROSCOPY; FOOD INTAKE; GRAPE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MALE; MARIGOLD; NONHUMAN; OPTIC NERVE; OXIDATION; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN STABILITY; RAT; RETINA CONE; RETINA MACULA AGE RELATED DEGENERATION; RETINA ROD; SOLUBILITY; THIN LAYER CHROMATOGRAPHY;

ACTIN CYTOSKELETON; ALDEHYDES; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BLINDNESS; CELLS, CULTURED; DIETARY SUPPLEMENTS; ELECTRORETINOGRAPHY; LIPOFUSCIN; MACULAR DEGENERATION; MALE; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; OXIDATION-REDUCTION; PHOTORECEPTOR CELLS, VERTEBRATE; PHYTOTHERAPY; PLANT PREPARATIONS; PROTEIN CARBONYLATION; PROTEIN STABILITY; RECEPTORS, VITRONECTIN; RETINA; RETINAL PIGMENT EPITHELIUM; VITIS;

MUS; VITACEAE;

EID: 84856278755     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.11.021     Document Type: Article

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