Prenylated acylphloroglucinol derivatives: Isoprenomics-based design, syntheses and antioxidative activities

Advances in Experimental Medicine and Biology

Volumn 737, Issue , 2012, Pages 251-256

  Tanaka, Ryo ^a   Uto, Yoshihiro ^a   Ohnaka, Kenta ^a   Ohta, Yuki ^a   Yazaki, Kazufumi ^b   Umemoto, Naoyuki ^c   Nakata, Eiji ^a   Hori, Hitoshi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c KIRIN HOLDINGS CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLPHLOROGLUCINOL; ANTIOXIDANT; COHUMULONE; COLUPULON; DEOXYHUMULONE; DI PRENYLATED ACYLPHLOROGLUCINOL; LINOLEIC ACID; LOW DENSITY LIPOPROTEIN; MONO PRENYLATED ACYLPHLOROGLUCINOL; UNCLASSIFIED DRUG; UTX 52; UTX 53; UTX 54;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; LIPID OXIDATION; PRIORITY JOURNAL; RADICAL REACTION;

ANTIOXIDANTS; CYCLOHEXANONES; DRUG DESIGN; FREE RADICAL SCAVENGERS; HUMANS; LINOLEIC ACID; LIPOPROTEINS, LDL; OXIDATION-REDUCTION; PHLOROGLUCINOL; PRENYLATION;

EID: 84856247997     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-1566-4_37     Document Type: Article

References (12)

1. Steinberg D (1995) Role of oxidized LDL and antioxidant in atherosclerosis. Adv Exp Med Biol 369:39-48
2. Witztum JL, Steinberg D (1991) Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest 88:1785-1792
3. Larson AE, Yu RR, Lee OA et al (1996) Antimicrobial activity of hop extracts against Listeria monocytogenes in media and in food. Int J Food Microbiol 33:195-207
4. Segawa S, Takata Y, Kaneda H et al (2007) Effects of a hop water extract on the compound 48/80-stimulated vascular permeability in ICR mice and histamine release from OVAsensitized BALB/c mice. Biosci Biotechnol Biochem 71:1577-1581
5. Hougee S, Faber J, Sanders A et al (2006) Selective inhibition of COX-2 by a standardized CO2 extract of Humulus lupulus in vitro and its activity in a mouse model of zymosan-induced arthritis. Planta Med 72:228-233
6. Tagashira M, Watanabe M, Uemitsu N (1995) Antioxidative activity of hop bitter acids and their analogues. Biosci Biotechnol Biochem 59:740-742
7. Uto Y, Ae S, Koyama D et al (2006) Artepillin C isoprenomics: design and synthesis of artepillin C isoprene analogues as lipid peroxidation inhibitor having low mitochondrial toxicity. Bioorg Med Chem 14:5721-5728
8. Uto Y, Ae S, Hotta A et al (2006) Artepillin C isoprenomics: design and synthesis of artepillin C analogues as antiatherogenic antioxidants. Adv Exp Med Biol 578:113-118
9. Zuurbier KWM, Fung SY, Scheffer JJC et al (1998) In-vitro prenylation of aromatic intermediates in the biosynthesis of bitter acids in Humulus lupulus . Phytochemistry 49:2315-2322
10. Blois MS (1958) Antioxidant determinations by the use of a stable free radical. Nature 181:1199
11. Liégeois C, Lermusieau G, Collin S (2000) Measuring antioxidant effi ciency of wort, malt, and hops against the 2,2′-azobis(2- amidinopropane) dihydrochloride-induced oxidation of an aqueous dispersion of linoleic acid. J Agric Food Chem 48:1129-1134
12. Yagi K (1998) Simple assay for the level of total lipid peroxides in serum or plasma. Methods Mol Biol 108:101-106