Artepillin C isoprenomics: Design and synthesis of artepillin C isoprene analogues as lipid peroxidation inhibitor having low mitochondrial toxicity

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 16, 2006, Pages 5721-5728

  Uto, Yoshihiro ^a   Ae, Shutaro ^a   Koyama, Daisuke ^a   Sakakibara, Mitsutoshi ^a   Otomo, Naoki ^a   Otsuki, Mamoru ^a   Nagasawa, Hideko ^a   Kirk, Kenneth L ^b   Hori, Hitoshi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Artepillin C isoprene analogue; Isoprenomics; Lipid peroxidation inhibitor; Rat liver mitochondria

Indexed keywords

ANTIOXIDANT; ARTEPILLIN C ISOPRENE; ISOPRENE; PROPOLIS; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; LIPID PEROXIDATION; LIPID SOLUBILITY; LIVER MITOCHONDRION; MITOCHONDRIAL TOXICITY; NONHUMAN; PRENYLATION; RAT; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; BUTADIENES; DRUG DESIGN; FATTY ACIDS; HEMITERPENES; LIPID PEROXIDATION; MALE; MITOCHONDRIA, LIVER; MODELS, CHEMICAL; PENTANES; PHENYLPROPIONATES; RATS; RATS, WISTAR;

EID: 33745634382     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.04.015     Document Type: Article

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