Selective inhibition of COX-2 by a standardized CO2 extract of Humulus lupulus in vitro and its activity in a mouse model of zymosan-induced arthritis

Planta Medica

Volumn 72, Issue 3, 2006, Pages 228-233

  Hougee, Sander ^a   Faber, Joyce ^a   Sanders, Annemarie ^a   Van Den Berg, Wim B ^b   Garssen, Johan ^a,c   Smit, H Friso ^a   Hoijer, Maarten A ^a  

^a NUMICO RESEARCH   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

COX 1; COX 2; Cyclooxygenase; Hops; Humulus lupulus; PGE2; Whole blood assay

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; CARBON DIOXIDE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; HUMULUS LUPULUS EXTRACT; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; ZYMOSAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG INHIBITION; ENZYME INHIBITION; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMULUS LUPULUS; IC 50; IN VITRO STUDY; INFLAMMATION; JOINT SWELLING; MALE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEOGLYCAN SYNTHESIS;

ADMINISTRATION, ORAL; ANIMALS; ARTHRITIS, EXPERIMENTAL; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; HUMANS; HUMULUS; INHIBITORY CONCENTRATION 50; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; PHYTOTHERAPY; PLANT EXTRACTS; ZYMOSAN;

ANIMALIA; HUMULUS LUPULUS;

EID: 33644996595     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-916212     Document Type: Article

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