Endoplasmic reticulum stress or mutation of an EF-hand Ca 2+-binding domain directs the FKBP65 rotamase to an ERAD-based proteolysis

Cell Stress and Chaperones

Volumn 16, Issue 6, 2011, Pages 607-619

  Murphy, Lindsey A ^a   Ramirez, Emily A ^a   Trinh, Van T ^a   Herman, Alexander M ^a   Anderson, Valen C ^a   Brewster, Jay L ^a  

^a PEPPERDINE UNIVERSITY   (United States)

Author keywords

Apoptosis; EF hand domain; Endoplasmic reticulum stress; FKBP65; Osteogenesis imperfecta; Peptidyl prolyl isomerase; Procollagen; Proteasome; Retrotranslocation; Rotamase; Tropoelastin

Indexed keywords

CHAPERONE; FK506 BINDING PROTEIN 65; PEPTIDYLPROLYL ISOMERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM BINDING; CALCIUM TRANSPORT; CELL FRACTIONATION; CELL STRESS; CONTROLLED STUDY; CYTOSOLIC FRACTION; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENDOPLASMIC RETICULUM STRESS; GENETIC TRANSFECTION; GOLGI COMPLEX; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN STABILITY; RAT; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

ANIMALS; BINDING SITES; CALCIUM; CELL LINE; CRICETINAE; EF HAND MOTIFS; ENDOPLASMIC RETICULUM STRESS; HUMANS; MICE; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; RATS; TACROLIMUS BINDING PROTEINS; TRANSCRIPTION, GENETIC;

EID: 84856231286     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-011-0270-x     Document Type: Article

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